What are the most effective and safe statins for cholesterol

It is clear that with age, the lumen of capillary, due to the build-up of cholesterol on their walls, considerably reduces, which as an outcome results in pathologies of the cardiovascular system. An effective approach of battling “bad” cholesterol is taking unique medications – statins. To comprehend which statins for cholesterol are the most effective and safe, let’s take a look at the comprehensive attributes of each of them.

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What are statins

So what are statins and why are they required?

Statins for cholesterol is a medication, the primary function of which is to avoid the deposition of “bad” cholesterol (cholesterol) on the walls of capillary by hindering the enzymes that produce cholesterol. In addition, the drug tends to thin the blood, which avoids embolism, and likewise increases the quantity of excellent cholesterol.

Indications for visit

Taking statins, like other medications, is plainly figured out by the indications of the client’s condition, for that reason it is required to comprehend at what cholesterol medical professionals recommend statins, when they are required, at what levels of cholesterol in the blood.

The medication needs to be taken in cases:

  • the client has atherosclerosis,
  • diabetes mellitus,
  • issues of the organs of the cardiovascular system: angina pectoris, ischemic heart illness,
  • suffered a stroke, along with a cardiac arrest,
  • pre-, postoperative duration after reconstructive intervention on the heart, coronary vessels,
  • hypercholesterolemia of differing intensity.

Patients are typically thinking about at what level of lipoproteins it is required to take statins, should they be taken if the indications are somewhat increased, however do not go beyond the cutoff level?

First of all, you ought to take note of the reality that the standard of cholesterol levels for each age, along with gender, is various. So, a high level of overall cholesterol is thought about to be a level of 6,2 mmol/liter, LDL (low density lipoprotein) or “bad” cholesterol – above 4,9 mmol/liter, HDL (high density lipoprotein) or “good” – less than 1,0, mmol/liter.

With age, the quantity of lipoproteins in the blood increases, and what is thought about typical at an older age will be thought about high for a young adult. So, whether it is required to take these drugs is chosen solely by the medical professional after the basic medical diagnosis of the client.

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Benefit and damage

So, statins for cholesterol, the advantages and damages of these drugs, how they can be beneficial and unsafe.

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The favorable impact of the usage of such medications, according to the suggestions of medical professionals, is:

  • decrease in the size of plaques (atherosclerotic),
  • enhancement of the lumen of the inner walls and the capability of capillary,
  • relief of inflammatory procedures in the vessels,
  • blood thinning (reduction in viscosity),
  • assistance of the body in case of ischemic illness, after cardiovascular disease, strokes, in the postoperative duration.

But regardless of the substantial favorable effect of the funds, there are likewise unfavorable evaluations. Among the unfavorable impacts of medications to decrease cholesterol levels on the body are kept in mind:

  • impact on the liver, statins trigger the work of liver enzymes,
  • issues with the muscular system, discomfort, weakening of fibers, in some cases decay, which can provoke kidney failure,
  • a sharp reduction in cholesterol levels, which likewise adversely impacts the performance of the body,
  • sleep issues, amnesia, lightheadedness,
  • the look of puffiness, a sharp boost in weight,
  • in guys – issues in the sexual sphere.

In addition to the showed adverse effects, uncharacteristic impacts are likewise possible – flatulence, extreme headache, skin rashes, extreme thirst, breathing system pathologies, queasiness, and throwing up. If you increase the dose of the drug, and likewise take it for a long period of time, then the danger of diabetes mellitus boosts.

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As you can see, sometimes, the drug can be exceptionally hazardous, so it deserves seeking advice from your medical professional whether you require to utilize the drug for longer, whether it deserves changing it with a much safer analogue.

How long to take them

The very first concern that clients ask a physician is the length of time statins ought to be taken, at what time, are there any extra drugs that require to be intoxicated in combination with the medication.

Considering all the favorable impacts, along with health threats, we will think about how to effectively take medications to decrease lipoprotein levels.

Taking statins with high cholesterol levels is performed according to the following plan – as soon as a day, ideally in the night, the dose of the drug depends upon the illness and the client’s condition. Evening medication consumption is because of the reality that lipids are actively formed exactly in the dark. But as for rosuvostatin, atorvastatin, they can be intoxicated at a hassle-free time for you, they work well throughout the day.

Please note, in addition to the reality that your medical professional will inform you how to take medications to lower lipoproteins, you will require to stick to a particular diet plan. With high cholesterol, you ought to quit fatty foods, foods high in lipoproteins, cigarette smoking, and alcohol. Sports are likewise required.

Combination with other drugs

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Due to the reality that statins are recommended as part of complex treatment, it is required to plainly comprehend and understand with which medications they can be integrated, and which duets can provoke a variety of liver illness.

Doctors call a mix of statins and medications for the treatment of heart illness a safe mix. Statins in mix with antiplatelet representatives, β-blockers, ACE inhibitors effectively combat the issues of the cardiovascular system, there are even intricate drugs.

As for medications that obstruct the impact of lipoprotein reducing representatives, statins cannot be integrated with: erythromycin and its derivatives, Boceprevir, Voriconazole, Diltiazem, Voriconazole, grapefruit juice, given that they obstruct the liver enzymes, that are accountable for the removal of statins.

Please keep in mind that statins are unwanted to take together with drugs, the active compound of which is fibrous acid (niacin, its analogues). These drugs likewise lower lipoprotein levels, so when integrated with statins, they increase the danger of liver failure.

Combination of the drug “Gemfibrozil” with statins is strictly forbidden.

As for drugs that bind and get rid of bile acids from the body (“Cholestyramine”, “Colestipol”), we should take statins 1 hour “before” taking the latter or “after”, however not earlier than 4 hours later on.

The most effective and most safe

It is rather rational that throughout an assessment with a suitable professional, clients clarify the efficiency and possible adverse effects of a specific statin, whether it impacts liver dysfunction and the body as a whole.

Please keep in mind that medications to lower blood cholesterol are divided into 2 groups (natural and artificial) and 4 generations.

Natural statins with high cholesterol were separated from fungis and are categorized as the initially generation of these drugs. These consist of simvastatin and lovastatin. However, they have less noticable medical residential or commercial properties, in addition, the unfavorable impacts of their consumption are rather substantial.

The 2nd group (generation) consists of fluvastatin. Compared with other drugs, it needs a longer duration of usage, while its concentration in the blood stays for an extended period.

The 3rd and 4th generations are represented by atorvastatin (III), rasuvastatin and pitavastatin (VI).

Once once again, it needs to be remembered that tablets for “bad” cholesterol ought to be recommended solely by a physician, based upon the medical diagnosis and the client’s health. The just thing that an ill individual can do, having a list of drugs, is to pick an analogue of the budget plan alternative in the drug store if the rate of the recommended one is expensive.

For example, effective statins of the last generation can be securely changed with a third-generation drug, they impact the liver in the exact same method, while for numerous it is more lucrative to purchase it.

Pay attention to the look of the tablets, there are choices on which there is no movie, however there is a longitudinal notch. Such funds can be divided and taken half a tablet, saving money on this.

Rosuvastatin and Pitavastatin

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The drugs for lowering the level of low density lipoproteins in the blood “Rosuvastatin” and “Pitavastatin” are the newest generation drugs, they are of artificial origin. Due to their noticable hydrophilicity, they virtually do not impact the liver and are more effective in withstanding the development of low density lipoproteins. The drugs do not impact muscle tissue, which, when utilized, enables you not to stress over cramps, along with myopathy.

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It ought to be kept in mind that these brand-new generation tools are more effective. For example, 40 mg of rosuvastatin by action changes 80 mg of the drug “Atorvastatin”.

Analogs of “Razuvastatin” are drugs: Mertenil, Rosart, Rosucard, Tevastor, Krestor, Rosulip. As for “Pitavastatin”, just “Livazo” medication is produced with a comparable active compound.


An representative for lowering the level of “bad” cholesterol in the blood of the 3rd generation, which inhabits a leading position amongst the drugs of this action. It is utilized for illness of the cardiovascular system, as a method to fight the build-up of cholesterol on the walls of capillary. Atorvastatin is offered in a dose of 40 to 80 mg and is utilized for pathologies of differing intensity.

Drugs such as Lipitor, Atorvastatin, Liptonorm, Liprimar, Atomax, Anvistat, Torvakard, Atorvox, Atoris, Canon, etc. are thought about analogues of the drug.


It comes from the 2nd generation drugs, has excellent effectiveness, however likewise a variety of adverse effects. There is one analogue of this drug – “Lescol”.


A drug for lowering the level of lipoproteins in the blood, the usage of which needs an accountable method, given that it has adverse effects. In addition, simvastatin needs to be taken for a long period of time to acquire the preferred outcome. When taken for 5 years, it decreases the danger of vascular pathologies, heart pathologies after a cardiac arrest, stroke, and ischemic illness by 10%.

The list of drugs with a comparable active compound: Simgal, Simvagexal, Simvacor, Simvacard, Vazilip, Vastatin, Simvastol, Ovenkor, Simlo.

How to change statins to lower cholesterol

It ought to be kept in mind that it is possible to decrease the level of lipoproteins, if they have actually not yet gone beyond the crucial sign, utilizing dietary nutrition, along with altering habits. So what alternatives for statins to lower cholesterol?

First of all, you require to take note of the spices which contain natural analogues of these drugs. Turmeric and garlic are in the lead. Include the following beverage in your diet plan: take an onion, peel, eject the juice and mix in equivalent quantities with liquid natural honey.

Also, the residential or commercial properties to decrease the level of lipoproteins in the blood are had by:

  • herring, however somewhat salted. It is much better to bake it in the oven, steam it,
  • chanterelles,
  • prunes,
  • nuts. They include monounsaturated fats, however keep in mind that they are really high in calories, so no greater than 30 gr.,
  • fish fat. It is abundant in omega-3 fats, which decrease lipoprotein levels. You can take it in pill kind, or merely increase your consumption of oily fish (herring, carp, salmon),
  • linen. Eating seeds, which likewise include Omega-3 in their structure, will decrease the development of cholesterol, avoiding embolism,
  • cellulose. By consisting of foods high in insoluble fiber in your diet plan, you “force” the body to excrete “bad” cholesterol. Give choice to fruits, veggies, enjoy unprocessed grains, avocados, broccoli, carrots, vegetables,
  • take soluble vitamin B3 or consist of in food: lean meat, cereals, milk, fresh herbs.

Exercise is another crucial consider reducing lipoprotein levels. It enables you to decrease high density lipoprotein levels and stabilize “good” cholesterol.

The high material of low density cholesterol in the blood, eventually, will provoke vascular obstruction and issues with the organs of the cardiovascular system. In this regard, taking medications to decrease this sign for a variety of classifications of clients is crucial. We hope that the details in the post assisted to comprehend the complexities of taking statins, their possible replacement with natural analogues.


Statins are drugs that lower cholesterol levels.

Tatyana Jakowenko

Editor-in-chief of the Detonic online magazine, cardiologist Yakovenko-Plahotnaya Tatyana. Author of more than 950 scientific articles, including in foreign medical journals. He has been working as a cardiologist in a clinical hospital for over 12 years. He owns modern methods of diagnosis and treatment of cardiovascular diseases and implements them in his professional activities. For example, it uses methods of resuscitation of the heart, decoding of ECG, functional tests, cyclic ergometry and knows echocardiography very well.

For 10 years, she has been an active participant in numerous medical symposia and workshops for doctors - families, therapists and cardiologists. He has many publications on a healthy lifestyle, diagnosis and treatment of heart and vascular diseases.

He regularly monitors new publications of European and American cardiology journals, writes scientific articles, prepares reports at scientific conferences and participates in European cardiology congresses.