Sartans for the treatment of arterial hypertension

Arterial hypertension is a steady boost in high blood pressure that differs in between 145/95 mm Hg. Art., however can increase greater. During the treatment of this illness, you must be incredibly mindful with the option of drugs. As the practice of treatment has actually currently revealed, sartans can be thought about the ideal and efficient approach for arterial hypertension. This kind of drugs – ARBs (angiotensin receptor blockers) – have actually been showing their quality, efficiency and impact on the body for several years.

ARB Mechanism of Action

The primary job of angiotensin receptor blockers is to prevent the activity of the RAAS, consequently this procedure has a favorable impact on the work of numerous human organs. Sartans are thought about the finest drugs on the list of drug groups for hypertension. It must be kept in mind that the rates policy of these drugs varies considerably from top quality drugs – they are more budget-friendly. According to the stats of taking sartans, 70% of clients go through treatment courses for approximately a number of years, while the level of efficiency of one or another organ does not reduce.

These truths can just show that angiotensin receptor blockers have a very little list of negative effects, and some do not have them at all.

As for verifying or refuting the reality that sartans trigger cancer, this type of debate is still carefully kept an eye on.

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ARBs can be divided into 4 subtypes based upon their chemical residential or commercial properties:

  • Biphenyl originated from tetrazole – Losartan, Irbesartan, Candesartan.
  • Non-phenol originated from tetrazole – Telmisartan.
  • Non-phenol netetrazoles – Eprosartan.
  • Non-cyclic substances – Valsartan.

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This kind of drugs have actually been presented into the treatment of arterial hypertension given that the 1990s, and at the minute a rather significant list of drugs can be kept in mind:

  • Losartan: Blocktran, Vasotenz, Zisakar, Karzartan, Kozaar, Lozap, Lozarel, Losartan, Lorista, Losacor, Lotor, Prezartan, Renicard,
  • Eprosartan: Teveten,
  • Valsartan: Valaar, Valz, Valsafors, Valsakor, Diovan, Nortivan, Tantordio, Tareg,
  • Irbesartan: Aprovel, Ibertan, Irsar, Firmasta,
  • Candesartan: Angiakand, Atakand, Hyposart, Kandecor, Candesar, Ordiss,
  • Telmisartan: Mikardis, Pritor,
  • Olmesartan: Cardosal, Olimestra,
  • Azilsartan: Edarbi.

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In addition to the above, you can discover from the category of these drugs and integrated parts: with diuretics, with Ca villains, with renin villains aliskiren.

Scope of ARBs

Angiotensin II receptor blockers are most efficient for illness such as:

  • arterial hypertension,
  • inadequate efficiency of the heart muscle,
  • Ischemic cardiovascular disease,
  • Myocardial infarction,
  • Problems with the operating of the cerebral circulatory system,
  • Lack of glucose in the body,
  • Nephropathy
  • Atherosclerosis,
  • Sexual conditions.

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Any of the drugs with antihypertensive results are permitted to be recommended, even in mix with other dose kinds. Type A – II drugs are typically recommended when they are chosen. In this case, they can be thought about much better than ACE inhibitors at increased pressure, sharp dives in high blood pressure. There is typically an allergy to inhibitors, which is practically difficult with the usage of sartans, and their favorable elements can be highlighted in terms of consumption throughout the advancement of type 2 diabetes mellitus, in addition to nephropathy, which cannot be stated about ACE.

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Of the contraindications, the list below types of population can be differentiated: ladies in position, lactation duration, kids’s age from birth to 14 years. It is taken with care in case of offenses of the kidneys, liver.


ARBs are mainly efficient high blood pressure medications. But the result of treatment with these medications might be various, depending upon the degree of advancement of the illness. In the case when the pressure is stably raised, A-II villains can reveal great performance.

Modern drugs – sartans are thought about one of the finest in terms of their impact on organs such as kidneys, heart, liver, brain, etc.

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The primary favorable elements of taking sartans can be thought about:

  • When taking this kind of drugs, a boost in the pulse rate is not observed,
  • With continuous medication, pressure rises do not happen,
  • With inadequate kidney function, under the impact of these drugs, a reduction in protein takes place,
  • Reduces the level of cholesterol, glucose, acid in the urine,
  • Have a favorable impact on the lipid procedure,
  • Improving sexual efficiency
  • No dry cough was observed while taking sartans.

It is necessary to understand! During the course of an intense stroke, it is not advised to utilize drugs to lower the pressure for 5-8 days. The just exception can be exceedingly high pressure readings.

You must likewise understand that sartans have an useful impact on muscle tissue, specifically great for those clients who have myodystrophy.

It is necessary to understand! When bilateral constricting of the kidney artery earnings, it is strictly prohibited to take Ara treatment representatives – kidney failure might establish.

Which one is much better to purchase?

Providing info on the finest ARBs is just impractical, as there are numerous efficient drugs in their amount and range, however each of them has its own functions. According to scientific research studies, it has actually been determined which sartans can aid with a specific illness:

DiseaseRequired drug
StrokeLosartan, Candesartan (with main stroke); Eprosartan (with secondary symptom).
DiabetesLosartan, Candesartan (preventive procedures)
Candesartan plus felodipine (preventive procedures of secondary symptom)
Valsartan (avoidance of nephropathy advancement)
Heart workLosartan – impacts the work of the left ventricle of the heart.
Candesartan is an efficient treatment for persistent cardiac arrest.
Valsartan (avoidance of issues in angina pectoris).
МетаболизмLosartan (steady reduction in acid in the urine)
Preventive procedures for arterial hypertensionCandesartan
Hypertension in the work environmentEprosartan
NephropathyMany drugs can help in reducing albuminuria.

It is necessary to understand! During treatment, it is strictly prohibited to recommend 2 or more types of sartans at the very same time!

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Benefits over other drugs

During the treatment of arterial hypertension, you must understand the choices of the drugs that cardiologists will recommend to you:

  • This kind of drugs can be utilized for more than a number of years,
  • Side results in this case are either very little or missing,
  • When dealing with arterial hypertension, tablets must be used up to two times every 12 hours,
  • The reduction in Hell does not happen quickly, within 20-24 hours,
  • With a currently steady pressure (120/80), when taking sartans, the pressure will not reduce even further,
  • Patients do not get utilized to this type of medication,
  • With an abrupt non-use of drugs of this group, there will be no abrupt pressure rises,
  • Modern types of drugs are extremely efficient and get quality throughout treatment and avoidance.
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Warning! After the initially consumption of blockers, do not anticipate a fast outcome. They are not capable of a fast reduction in high blood pressure, however they have the ability to bring it back to regular within 10-15 days, and a more powerful impact after 20-25 days of administration.

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The drugs must be taken as follows (example):

PreparationPeak direct exposure (hour)T ½The duration of taking the drugDosage in 24 hoursBioavailabilityThe volume of circulation in the body
Losartanfrom an hour to 4xFrom 5 9 upUp to two times every 24 hours+553334
ValsartanTwo to 4From 5 9 upOnce every 24 hours+802517
IrbesartanAn hour to 2+11Once every 24 hours+145+60+52
CardesartanThree to 4+2Up to two times every 24 hours+8159
EprosartanAn hour to 2From 5 9 upUp to two times every 24 hours+45013306
Telmisartan30 minutes to an hourAt least 20Once every 24 hours40 and more+42490

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Interaction of sartans and diuretics

Often, cardiologists demand ARB treatment and diuretics.

In numerous drug stores there are a significant number of pressure tablets, that include sartans and diuretics:

  • Atacand – 0,16 g Candesartan and 12.5 mg Hydrochlorothiazide,
  • Co-diovan – 80 mg Valsartan and 12.5 mg Hydrochlorothiazide,
  • Lorista – 12.5 mg Hydrochlorothiazide and 50-100 mg Losartan,
  • Micardis – 80 mg Telmisartan and 12.5 mg Hydrochlorothiazide,
  • Teveten – Eprosartan – 600 mg and 12.5 mg Hydrochlorothiazid.

In conclusion, I wish to keep in mind that according to medical research studies, all of the above ARBs for arterial hypertension have a protective impact not just on the work of the heart, however likewise on numerous internal organs of an individual, consequently minimizing the danger of stroke, cardiovascular disease, cardiac arrest, MBS and numerous other major for life illness.

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Tatyana Jakowenko

Editor-in-chief of the Detonic online magazine, cardiologist Yakovenko-Plahotnaya Tatyana. Author of more than 950 scientific articles, including in foreign medical journals. He has been working as a cardiologist in a clinical hospital for over 12 years. He owns modern methods of diagnosis and treatment of cardiovascular diseases and implements them in his professional activities. For example, it uses methods of resuscitation of the heart, decoding of ECG, functional tests, cyclic ergometry and knows echocardiography very well.

For 10 years, she has been an active participant in numerous medical symposia and workshops for doctors - families, therapists and cardiologists. He has many publications on a healthy lifestyle, diagnosis and treatment of heart and vascular diseases.

He regularly monitors new publications of European and American cardiology journals, writes scientific articles, prepares reports at scientific conferences and participates in European cardiology congresses.