Penelitian baru mengidentifikasi serangkaian sinyal kunci yang mengontrol produksi lendir di paru-paru


Proper lung feature counts on the specific equilibrium of specific epithelial cells (cells that line the surface areas of the body) that coordinate features to keep homeostasis. One vital lung cell kind is the cup cell, which produces mucus that assists secure the lining of the bronchus (significant airway of the lung) and also catch bacteria. Goblet cells are frequently raised in lung conditions, however signals that bring about their dysregulation are not well comprehended.

Researchers have actually currently uncovered a new set of signals that control the production of cup cellsin the lung “By altering the proteins that control these signals we are able to either increase or decrease the production of goblet cells which offers potential new avenues for therapeutically targeting goblet cells in lung disease,” clarified equivalent writer Bob (Xaralabos) Varelas,Ph D., associate teacher of biochemistry and biology at Boston University School of Medicine.

The scientists made use of a speculative design bring a hereditary removal of Yap and also Taz, which are genetics that inscribe healthy proteins that control a crucial signaling networkin the lung They contrasted the hereditary removal design with a “control” design and also discovered that the Yap/Taz removal design had serious lung damages and also raised cup cell number that was related to raised mucin production.

In order to recognize just how loss of Yap/Taz resulted in raised cup cell numbers, the scientists separated cells from the speculative design and also human lungs and also cultured them in the laboratory. They after that made use of genetics expression and also chromatin binding evaluations to find just how these healthy proteins control a network of genetics vital formucus production Finally, they made use of these cells in the laboratory to examination preventions of cup cell distinction and also mucus production.

According to the scientists, numerous lung conditions display a development of cup cells consisting of bronchial asthma, COPD, Cystic Fibrosis and also persistent respiratory disease. “By identifying new regulators of goblet cell production, we offer insight into mechanisms that may contribute to these diseases. By targeting these signals we can repress the production and maintenance of goblet cells and therefore may offer therapeutic directions for limiting the expansion of these cells in lung disease,” claimed Varelas.

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