Ceruloplasmin role in the body norm in the analysis of blood decrease

What to do with deviations in the test results for ceruloplasmin? If the protein is elevated, this usually indicates infectious, inflammatory and autoimmune pathologies, as well as tissue damage. In this case, it is necessary to treat the underlying pathology. After a course of therapy, the level of ceruloplasmin in the blood returns to normal.

If ceruloplasmin is lowered due to Wilson-Konovalov disease, then the patient is shown a special diet with a restriction in the diet of products containing copper. The patient is prescribed Unitiol and Kuprenil preparations. These drugs bind and remove copper ions from tissues.

Additionally, therapy is carried out using B vitamins. These drugs stop neurological manifestations.

In case of impaired liver function, an organ transplant is performed. Such an operation is done only in severe cases, as this is a rather risky procedure. However, an organ transplant helps to completely get rid of congenital hepatocyte dysfunction.

The analysis for ceruloplasmin is of great diagnostic value in identifying diseases associated with impaired copper metabolism, including Wilson-Konovalov disease. The results of the study are widely used in hematology, rheumatology, infectious diseases and pediatrics. If the indicators deviate from the norm, treatment of the underlying disease, which caused a violation of copper metabolism, is necessary.

Ceruloplasmin is a copper-containing protein (glycoprotein) present in blood plasma. Ceruloplasmin contains about 95% of the total amount of copper in human serum. Ceruloplasmin performs a number of important biological functions in the body: it increases the stability of cell membranes, participates in immunological reactions (in the formation of the body’s defenses), ion exchange, has an antioxidant (preventing lipid peroxidation of cell membranes) effect, stimulates hematopoiesis (hematopoiesis).

An increase in ceruloplasmin concentration is observed in patients with acute and chronic infectious diseases, liver cirrhosis, hepatitis, myocardial infarction, systemic diseases, lymphogranulomatosis, and in patients with schizophrenia. The content of ceruloplasmin in blood serum also increases with malignant neoplasms of various localization (cancer of the lung, breast, cervix, gastrointestinal tract) by 1,5 – 2 times, reaching more significant values ​​with the prevalence of the process.

The insufficiency of ceruloplasmin due to a violation of its synthesis in the liver causes Konovalov-Wilson’s disease (a hereditary liver disease associated with impaired protein and copper metabolism), which is an important diagnostic indicator. Low levels of ceruloplasmin in serum are also observed with nephrotic syndrome, diseases of the gastrointestinal tract, and severe liver diseases.

Special preparation for the study is not required. The general requirements for preparing for research must be followed.

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1. For most studies, it is recommended to donate blood in the morning, from 8 to 11 hours, on an empty stomach (at least 8 hours should elapse between the last meal and blood sampling, water can be drunk as usual), on the eve of the study, a light dinner with restriction intake of fatty foods. For tests for infections and emergency studies, it is permissible to donate blood 4-6 hours after the last meal.

ATTENTION! Special preparation rules for a number of tests: on an empty stomach, after 12-14 hours of fasting, you should donate blood for gastrin-17, lipid profile (total cholesterol, HDL cholesterol, LDL cholesterol, VLDL cholesterol, triglycerides, lipoprotein (and ), apolipoprotein A1, apolipoprotein B); glucose tolerance test is performed in the morning on an empty stomach after 12-16 hours of fasting

3. On the eve of the study (within 24 hours) to exclude alcohol, intense physical activity, taking medications (as agreed with the doctor).

4. For 1-2 hours before blood donation, refrain from smoking, do not drink juice, tea, coffee, you can drink still water. Exclude physical stress (running, fast climbing stairs), emotional arousal. 15 minutes before blood donation, it is recommended to relax, calm down.

5. Do not donate blood for laboratory research immediately after physiotherapy procedures, instrumental examination, x-ray and ultrasound examinations, massage and other medical procedures.

6. When monitoring laboratory parameters in dynamics, it is recommended to conduct repeated studies under the same conditions – in the same laboratory, donate blood at the same time of day, etc.

7. Blood for research should be donated before taking medications or not earlier than 10-14 days after their cancellation. To assess the control of the effectiveness of treatment with any drugs, you need to conduct a study 7-14 days after the last dose.

If you are taking medication, be sure to notify your doctor.

image009 - Ceruloplasmin role in the body norm in the analysis of blood decrease

Ceruloplasmin is synthesized in the liver, here it captures copper atoms – each ceruloplasmin molecule can transport up to 8 copper atoms – it transportes them to the destination, then it is destroyed, its decomposition products are redirected to the liver, where they are first excreted with bile into the intestines, and then completely out of the body. In addition to transporting copper, the duties of ceruloplasmin in the body include:

  • oxidation of ferrous iron to ferric,
  • participation in the oxidation reactions of serotonin and catecholamines,
  • preventing the oxidation of lipids that are contained in cell walls.
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In addition, like all alpha-2-glycoproteins, ceruloplasmin is a protein involved in acute inflammatory processes and inhibits the action of serum histaminase.

Indications for use

Apply iv drip in a hospital setting, the rate of administration is 30 drops per minute.

In the preoperative period, the daily dose of ceruloplasmin is 1,5-2,0 mg/kg

The course of treatment usually includes 7-10 intravenous administrations, which are carried out every day or every 2 days, as directed by the doctor, taking into account the patient’s condition

A single dose should be determined depending on the amount of blood loss:

  • with moderate blood loss – from 1,5 mg/kg;
  • with massive – no more than 6 mg/kg.

Therapy usually includes daily infusions for 7-10 days.

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Acute osteomyelitis

Daily dose: 2,5 mg/kg, the standard course of treatment consists of 5 iv infusions, which are carried out daily or every other day.

Daily dose: 5 mg/kg, the course of treatment includes 2-3 iv injections, which are carried out daily or every other day, then the therapy is continued, reducing the dosage to 2,5 mg/kg for the next 3-7 infusions.

  • intoxication;
  • anemia (of various origins, including preoperative preparation for debilitated patients);
  • leukopenia;
  • cachexia;
  • massive and moderate blood loss (for example, during surgical interventions);
  • acute or chronic osteomyelitis.

The main indications for passing a blood test for ceruloplasmin are:

  • hepatocerebral dystrophy;
  • microcytic hypochromic iron deficiency anemia that does not respond to iron therapy;
  • liver disease, neurodegenerative signs, impaired formation of connective tissue in children.

With purulent-septic complications.

Attention!

The contents of the ampoule must be dissolved in a 0,9 percent solution of sodium chloride (200 ml volume).

Svetlana Borszavich

General practitioner, cardiologist, with active work in therapy, gastroenterology, cardiology, rheumatology, immunology with allergology.
Fluent in general clinical methods for the diagnosis and treatment of heart disease, as well as electrocardiography, echocardiography, monitoring of cholera on an ECG and daily monitoring of blood pressure.
The treatment complex developed by the author significantly helps with cerebrovascular injuries and metabolic disorders in the brain and vascular diseases: hypertension and complications caused by diabetes.
The author is a member of the European Society of Therapists, a regular participant in scientific conferences and congresses in the field of cardiology and general medicine. She has repeatedly participated in a research program at a private university in Japan in the field of reconstructive medicine.

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