Aspirin – instructions for use, analogues of the drug

The dose kind for the release of Aspirin is tablets: round, white, biconvex, beveled around the edge, on the one side of the tablet is the engraving “ASPIRIN 0,5”, on the other – a print in the kind of a brand (“Bayer cross”) (10 pcs.) in blisters, 1, 2 or 10 blisters in a pack of cardboard).

Composition of 1 tablet:

  • active compound: acetylsalicylic acid – 500 mg;
  • auxiliary elements: corn starch, microcrystalline cellulose.

One tablet includes the active compound – acetylsalicylic acid in a quantity of 0,1 or 0,3 g, in addition to extra elements: cellulose, ethacrylate and methacrylic acid (copolymer), talc, polysorbate, triethyl citrate, salt lauryl sulfate, corn starch.

Enteric Coated Tablets1 table.
active compound:
acetylsalicylic acid100/300 mg
excipients: cellulose powder – 10/30 mg; corn starch – 10/30 mg
enteric covering: copolymer of methacrylic acid and ethacrylate (1: 1) – 7,857/27, 709 mg; polysorbate 80 – 0,186/0,514 mg; salt lauryl sulfate – 0,057/0,157 mg; talc – 8,1/22,38 mg; triethyl citrate – 0,8/2,24 mg

Application in pregnancy and lactation

Aspirin is contraindicated in the initially and 3rd trimesters of pregnancy due to the capability of acetylsalicylic acid to permeate the placental barrier. In the 2nd trimester, admission needs care, just as recommended by the medical professional and if the advantages for the mom are gone beyond over the danger to the fetus. During lactation, Aspirin, according to evaluations and instructions, is forbidden, due to the fact that it enters breast milk.

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Separate retrospective epidemiological research studies have actually revealed that the use of ASA in the initially trimester of pregnancy boosts the danger of abnormality (consisting of splitting of the tough taste buds and heart problems). However, the outcomes of other research studies, in which 32 mom-kid couples participated, recommend that taking Aspirin in restorative dosages not going beyond 000 mg each day does not increase the occurrence of hereditary malformations.

Since the research study outcomes are combined, it is not advised to use Aspirin in the initially trimester of pregnancy. When taking in the 2nd trimester of pregnancy, care should be taken, the drug is acceptable just after a cautious evaluation of the ratio of the advantages of treatment for the mom and the threats for the kid. In the case of a long course of treatment, the daily dosage of ASA must not surpass 150 mg.

In the 3rd trimester, taking Aspirin in high dosages (more than 300 mg each day) can cause pregnancy overload and weakening of labor, in addition to early closure of the ductus arteriosus (ductus arteriosus) in a kid. Taking ASA in substantial dosages soon prior to birth in some cases results in the advancement of intracranial bleeding, specifically in early infants.

If it is needed to use Aspirin throughout lactation, it is advised to stop breastfeeding.

Inhibition of GHG synthesis can have an unfavorable result on pregnancy and the advancement of an embryo or fetus.

Epidemiological research studies on the use of GHG synthesis inhibitors in early pregnancy are fretting about the danger of abortion and fetal malformations, most likely increasing with increasing dosage and period of treatment. Available information do not validate the association in between ASA consumption and an increased danger of abortion.

There are clashing information from epidemiological research studies concerning the relationship in between the use of ASA and problems in fetal advancement, which do not enable to leave out an increased danger of gastroschisis. According to a potential research study including 14800 ladies in early pregnancy (1st – 4th month), no boost in fetal advancement problems was identified with ASA.

Animal research studies have actually shown reproductive toxicity of ASA. In the initially trimester of pregnancy, the use of drugs consisting of ASA is contraindicated.

In the 2nd trimester of pregnancy, salicylates can be recommended just with a stringent evaluation of the danger and advantages to the mom and fetus.

Women preparing a pregnancy or in the 2nd trimester of pregnancy must decrease the dosage of ASA and the period of treatment.

In the 3rd trimester of pregnancy, GH synthesis inhibitors can trigger suppression of uterine contractions, resulting in inhibition of labor, a boost in bleeding time and a boost in the antiplatelet result (even when ASA is utilized in low dosages). The fetus might establish cardiopulmonary intoxication with early closure of the ductus arteriosus and the advancement of lung high blood pressure, in addition to impaired kidney function, approximately the advancement of kidney failure, accompanied by oligohydramnios. The use of ASA in the 3rd trimester of pregnancy is contraindicated.

Salicylates and their metabolites in little amounts enter breast milk. The periodic consumption of salicylates throughout breastfeeding is not accompanied by the advancement of unfavorable responses in the child and does not need termination of breastfeeding. However, with extended use of the drug or its administration in a high dosage, breast-feeding must be ceased as quickly as possible.

Form of problem

Enteric-layered tablets, 100 mg, 300 mg.

Enteric-layered tablets, 100 mg: 10 or 14 tablets. in blisters from Al/PP. 2 bl. 10 tablets or 2, 4 or 7 bl. 14 tablets put in a cardboard box.

Enteric layered tablets, 300 mg: 10 or 14 tablets. in blisters from Al/PP. 2 bl. 10 tablets or 2 or 4 bl. 14 tablets put in a cardboard box.

White layered tablets liquifying in the intestinal tracts. Packages of 20,28 and 56 pieces.

Use in youth

7968823 llj - Aspirin - instructions for use, analogues of the drug

According to the instructions, the use of Aspirin and other drugs with acetylsalicylic acid is forbidden for kids under 15 years of ages due to the increased danger of Reye’s syndrome due to viral illness. This condition is identified by the look of encephalopathy and intense fatty degeneration of the liver with a parallel course of intense liver failure.

Aspirin tablets are not utilized in kids under 15 years of age who experience intense breathing infections arising from viral infections due to the danger of Reye syndrome (intense fatty degeneration of the liver and encephalopathy, accompanied by the advancement of intense liver failure).

Pharmacodynamics and pharmacokinetics

The system of the antiplatelet action of acetylsalicylic acid (ASA) is based upon the irreparable inhibition of COX-1, as an outcome of which TxA2 synthesis is obstructed and platelet aggregation is reduced. The anti-aggregation result is most noticable in platelets, due to the fact that they are unable to re-manufacture COX. It is thought that ASA has other systems for reducing platelet aggregation, which broadens its scope in numerous vascular illness.

ASA likewise has anti-inflammatory, analgesic and antipyretic impacts.

Suction. After oral administration, ASA is quickly and totally taken in from the gastrointestinal system. ASA is partly metabolized throughout absorption. During and after absorption, ASA develops into the primary metabolite – salicylic acid. Due to the reality that the tablets are covered with an acid-resistant shell, ASA is launched not in the stomach, however in the alkaline environment of the duodenum.

With synchronised consumption with food, a decline in the absorption of ASA is kept in mind without impacting the degree of absorption. The lower absorption rate of enteric-layered ASA tablets does not impact the plasma direct exposure of ASA and its capability to prevent platelet aggregation throughout extended treatment with low dosages of the drug.

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Distribution. ASA and salicylic acid mostly bind to plasma proteins and are quickly dispersed in the body. Salicylic acid crosses the placenta and is excreted in breast milk.

Metabolism. The primary metabolite of ASA is salicylic acid. The metabolic process of salicylic acid is performed in the liver with the development of salicirulic acid, phenolic salicylic acid glucuronide, salicyl glucuronide and gentisuric acid.

Breeding. The excretion of salicylic acid is dosage-reliant, given that its metabolic process is restricted by the abilities of the enzymatic system. T1/2 is from 2-3 hours when utilizing ASA in low dosages and approximately 15 hours when utilizing the drug in high dosages (typical dosages of ASA as an analgesic). Salicylic acid and its metabolites are excreted by the kidneys. According to pharmacokinetic information, there are no medically substantial variances in the concentration-dosage curve when taking ASA in a dosage of 100 to 500 mg.

Once in the gastrointestinal system, the active compound is transformed into salicylic acid. Acetylsalicylic acid hinders platelet aggregation by obstructing the synthesis of thromboxane A2. It breaches the system of cyclooxygenase production.

The drug has anti-inflammatory and antipyretic impacts. Also, the medication is utilized for arthritis and osteoarthritis, influenza and colds.

The optimum concentration of acetylsalicylic acid – after 20 minutes, after administration, salicylic acid – after an hour. If a dose kind covered with a membrane soluble in the intestinal tract is utilized, then the absorption of the active compounds happens later on, not in the stomach. The result of the drug is extended.

Acid is excreted generally through the kidneys and this happens within 2-15 hours, depending upon the dose.

Drug Interactions

Round, biconvex tablets of white color, in sample – an uniform mass of white color, with a shell of the very same color.

Acetylsalicylic acid improves the poisonous homes of methotrexate, in addition to the unfavorable impacts of triiodothyronine, narcotic analgesics, sulfanilamides (consisting of co-trimoxazole), other NSAIDs, thrombolytics – platelet aggregation inhibitors, hypoglycemic drugs for oral administration, indirect anticoagulant. At the very same time, it deteriorates the result of diuretics (furosemide, spironolactone), antihypertensive drugs, and uricosuric drugs (probenecid, benzbromarone).

With the integrated use of Aspirin with ethanol-consisting of drugs, alcohol and glucocorticosteroids, the destructive result of ASA on the intestinal mucosa boosts, which increases the danger of intestinal bleeding.

Acetylsalicylic acid boosts the concentration of lithium, barbiturates and digoxin in the body with synchronised use. Antacids, that include aluminum and/or magnesium hydroxide, decrease and decrease the absorption of ASA.

The instructions for use of Aspirin show a possible drug interaction of acetylsalicylic acid with other medications:

  • The drug boosts the poisonous result of methotrexate, narcotic analgesics, other NSAIDs, oral hypoglycemic representatives.
  • The tool boosts the activity of sulfonamides, lowers antihypertensive drugs and diuretics (Furosemide).
  • In mix with glucocorticosteroids, alcohol and ethanol-consisting of representatives, the danger of bleeding, damage to the intestinal mucosa boosts.
  • The tool boosts the concentration of digoxin, lithium preparations, barbiturates.
  • Antacids with magnesium or aluminum hydroxide sluggish the absorption of the drug.

Contraindications Aspirin Cardio

The Aspirin instructions state the following contraindications, in which the use of the drug is forbidden:

  • worsening of disintegration or intestinal ulcers;
  • hemorrhagic diathesis;
  • very first and 3rd trimesters of pregnancy, breastfeeding;
  • bronchial asthma;
  • hypersensitivity to acetylsalicylic acid, NSAIDs or other elements of the structure of the drug;
  • age of 15 years;
  • liver illness;
  • decompensated cardiac arrest;
  • intestinal bleeding.

main avoidance of intense myocardial infarction in the existence of danger aspects (consisting of diabetes mellitus, hyperlipidemia, high blood pressure, weight problems, smoking cigarettes, aging) and myocardial infarction;

unsteady angina pectoris (consisting of presumed advancement of intense myocardial infarction) and steady angina pectoris;

stroke avoidance (consisting of in clients with short-term cerebrovascular mishap);

avoidance of short-term cerebral circulatory conditions;

avoidance of thromboembolism after operations and intrusive vascular interventions (consisting of coronary artery bypass grafting, carotid artery endarterectomy, arteriovenous artery bypass grafting, coronary artery angioplasty and stenting, carotid artery angioplasty);

avoidance of deep vein apoplexy and thromboembolism of the lung artery and its branches (consisting of with extended immobilization as an outcome of comprehensive surgical treatment).

hypersensitivity to ASA, excipients of the drug and other NSAIDs;

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bronchial asthma caused by taking salicylates and NSAIDs;

a mix of bronchial asthma, frequent polyposis of the nose and paranasal sinuses and intolerance to ASA;

erosive and ulcerative sores of the intestinal system (in the intense phase);

integrated use with methotrexate at a dosage of 15 mg/week or more;

serious liver dysfunction;

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persistent cardiac arrest III – IV practical class according to NYHA category;

pregnancy (I and III trimester);

the duration of breastfeeding;

kids and teenagers under 18 years of age (due to absence of information on effectiveness and security).

hypersensitivity to analgesics, anti-inflammatory drugs, antirheumatic drugs, in addition to allergies to other compounds;

the existence in the history of ulcerative sores of the intestinal system, consisting of persistent and frequent intestinal sores or a history of intestinal bleeding;

synchronised use with anticoagulants (see. “Interaction”);

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irregular liver function;

circulatory conditions arising from atherosclerosis of the kidney arteries, heart disease, hypovolemia, comprehensive surgical treatment, sepsis, cases of huge bleeding; bronchial asthma, persistent breathing illness, hay fever, nasal polyposis, persistent illness of the breathing system, in addition to allergies to other drugs (consisting of skin responses, itching, urticaria);

serious glucose-6-phosphate dehydrogenase shortage;

II trimester of pregnancy;

presumed surgical intervention (consisting of small ones, such as tooth extraction);

integrated use with the following drugs (see “Interaction”): methotrexate in a dosage of less than 15 mg/week; anticoagulants, thrombolytic or other antiplatelet representatives; NSAIDs (consisting of ibuprofen, naproxen); digoxin; hypoglycemic representatives for oral administration (sulfonylurea derivatives) and insulin; valproic acid; alcohol (alcohols in specific); SSRIs.

At a temperature level not greater than 25 ° C.

Keep out of the reach of kids.

Do not use after the expiration date printed on the plan.

Synonyms of nosological groups

Heading ICD-10ICD-10 illness synonyms
E14 Diabetes, undefinedSevere vascular issue of diabetes
Diabetes
Diabetic asthenia
Thyroid dysfunction
Diabetes Obesity
Diabetes
G45 Transient Transient Cerebral Ischemic Attacks and Related SyndromesTransient ischemic attacks
Drop attacks
Ischemic Neurological Disorders
Ischemic mental retardation
Acute cerebrovascular deficiency
Repeated Transient Brain Ischemia
Transient Ischemic Attack
Transient ischemic condition
Transient ischemic cerebrovascular mishap
Transient ischemic condition
Transient cerebrovascular mishap
Subclavian Theft Syndrome
Transient ischemic attack
Transient anemia
Transient cerebral ischemic attack
Transient cerebral anemia
Transient ischemic attacks
Transient ischemic attack
Chronic cerebral anemia
I10 Essential (main) high blood pressureHypertension
Arterial high blood pressure
Crisis arterial high blood pressure
Arterial high blood pressure made complex by diabetes
Hypertension
Sudden boost in high blood pressure
Hypertensive circulatory conditions
Hypertensive state
Hypertensive crises
Hypertension
Arterial high blood pressure
Malignant high blood pressure
Essential high blood pressure
Hypertonic illness
Hypertensive crises
Hypertensive crisis
Hypertension
Malignant high blood pressure
Malignant high blood pressure
Isolated systolic high blood pressure
Hypertensive crisis
Exacerbation of high blood pressure
Primary arterial high blood pressure
Transient arterial high blood pressure
Essential arterial high blood pressure
Essential arterial high blood pressure
Essential high blood pressure
Essential high blood pressure
I15 Secondary high blood pressureHypertension
Arterial high blood pressure
Crisis arterial high blood pressure
Arterial high blood pressure made complex by diabetes
Hypertension
Vasorenal high blood pressure
Sudden boost in high blood pressure
Hypertensive circulatory conditions
Hypertensive state
Hypertensive crises
Hypertension
Arterial high blood pressure
Malignant high blood pressure
Symptomatic high blood pressure
Hypertensive crises
Hypertensive crisis
Hypertension
Malignant high blood pressure
Malignant high blood pressure
Hypertensive crisis
Exacerbation of high blood pressure
Renal high blood pressure
Renovascular arterial high blood pressure
Renovascular high blood pressure
Symptomatic arterial high blood pressure
Transient arterial high blood pressure
I20 Angina [angina pectoris]Heberden’s illness
Angina pectoris
Angina attack
Recurrent angina pectoris
Spontaneous angina
Stable angina pectoris
Angina Pectoris Syndrome X
Angina pectoris
Angina pectoris (seizure)
Angina pectoris
Angina pectoris
Progressive angina pectoris
Angina pectoris combined
Angina pectoris spontaneous
Stable angina pectoris
Chronic steady angina pectoris
I20.0 Unstable AnginaHeberden’s illness
Unstable angina
Angina pectoris unsteady
I21 Acute myocardial infarctionLeft ventricular infarction
Q-wave myocardial infarction
Acute myocardial infarction
Non-transmural myocardial infarction (subendocardial)
Acute myocardial infarction
Myocardial infarction with a pathological Q wave and without it
Myocardial infarction transmural
Myocardial infarction made complex by cardiogenic shock
Non-transmural myocardial infarction
The intense stage of myocardial infarction
Acute myocardial infarction
Subacute phase of myocardial infarction
Subacute duration of myocardial infarction
Subendocardial myocardial infarction
Coronary Artery Thrombosis (Arteries)
Threatening myocardial infarction
I22 Repeated myocardial infarctionAtherosclerosis and the possibility of repeating cardiovascular disease
Myocardial infarction duplicated
Relapses of myocardial infarction
I26.9 Pulmonary embolism without reference of intense lung heartPulmonary infarction
I63 Cerebral InfarctionIschemic stroke
Coronary artery illness
Ischemic mental retardation
Ischemic stroke
Ischemic stroke and its effects
Ischemic cerebral stroke
Ischemic cerebrovascular mishap
Ischemic mental retardation
Ischemic mental retardation
Ischemic condition
Cerebral anemia
Acute brain hypoxia
Acute cerebral anemia
Acute ischemic cerebrovascular mishap
Acute cerebral infarction
Acute ischemic stroke
Acute ischemic stroke
Focal cerebral anemia
History of stroke
Repeated stroke
Morgagni-Adams-Stokes Syndrome
Chronic cerebral anemia
Cerebrovascular stroke
Embolic stroke
I64 Stroke, not defined as hemorrhage or cardiovascular diseaseCulminating stroke
Stroke
Stroke on the go
Microstroke
Brain strokes
Primary stroke
I74 Embolism and arterial apoplexyArterial apoplexy
Arteriothrombosis
Subacute and persistent arterial apoplexy
Subacute peripheral arterial apoplexy
Postoperative apoplexy
Vascular apoplexy
Vascular embolism
Aortocoronary shunt apoplexy
Arterial apoplexy
Arterial Thrombosis
Coronary Artery Thrombosis
Coronary apoplexy
Blood vessel apoplexy
Ischemic stroke apoplexy
General Thrombosis
Oncological apoplexy
Vascular apoplexy
Thrombosis of effort (stress)
Thrombosis in the postoperative duration
Thrombotic problems
Thromboembolic illness
Thromboembolic problems
Thromboembolic syndrome
Thromboembolic issue
Thromboembolic issue in the postoperative duration
Arterial Thromboembolism
Partial vascular apoplexy
Embolism
Artery Embolism
I82.8 Embolism and apoplexy of other defined veinsVenous apoplexy of the vessels of the eye
Acute Deep Vein Thrombosis
Acute deep vein apoplexy of the extremities and hips
Acute deep vein apoplexy of the legs
Vein apoplexy of internal organs
Deep vein apoplexy of the lower extremities
Subclavian vein apoplexy
R54 Old AgeExternal indications of aging
Age-associated eye illness
Age-associated visual problems
Age-associated vascular illness
Age irregularity
Age-associated modifications in visual skill
Age-associated involutional modifications in the brain
Age-associated conditions
Age-associated hearing problems
Gerontological practice
Dementia
Calcium and Vitamin D3 Deficiency in the Elderly
Vascular and age-associated brain illness
Involutional anxiety
Involutional Depression
Metabolism correction in the senior and senile
Malnutrition in the senior and senile.
Older Behavioral Disorders
Senile dementia
Senile dementia
Senile Depression
Senile colpitis
Senile psychosis
Involutional age syndrome
Age-associated hearing loss
Aging
Brain aging
Body aging
Senile dementia
Old age
Senile involutional psychosis
Senile psychosis
Memory problems in senior clients
Z100 * CLASS XXII Surgical PracticeAbdominal surgical treatment
Adenomectomy
Amputation
Coronary Artery Angioplasty
Carotid angioplasty
Antiseptic skin treatment for injuries
Antiseptic Hand Treatment
Appendectomy
Atheectomy
Balloon Coronary Angioplasty
Vaginal hysterectomy
Coronary Bypass
Interventions on the vaginal area and cervix
Bladder interventions
Oral intervention
Reconstructive surgical treatment
Hand health of medical workers
Gynecological surgical treatment
Gynecological interventions
Gynecological surgical treatment
Hypovolemic shock throughout operations
Purulent injury disinfection
Disinfection of injury edges
Diagnostic interventions
Diagnostic treatments
Diathermocoagulation of the cervix
Long Surgery
Fistula Catheter Replacement
Orthopedic Surgery Infection
Artificial heart valve
Cystectomy
Short-term outpatient surgical treatment
Short-term operations
Short-term surgeries
Cricothyrotomy
Blood loss throughout surgical treatment
Bleeding throughout surgical treatment and in the postoperative duration
Cultocentesis
Laser coagulation
Laser coagulation
Retinal laser coagulation
Laparoscopy
Laparoscopy in gynecology
Liquor fistula
Small gynecological operations
Minor surgical treatment
Mastectomy and subsequent cosmetic surgery
Mediastinotomy
Microsurgical operations on the ear
Mucogingival surgical treatment
Suturing
Minor surgical treatment
Neurosurgery
Eyeball immobilization in ophthalmic surgical treatment
Orchiectomy
Complications after tooth extraction
Pancreatectomy
Pericardectomy
Rehabilitation after surgical treatment
Convalescence duration after surgical treatment
Percutaneous transluminal coronary angioplasty
Pleural thoracocentesis
Postoperative and post-terrible pneumonia
Preparation for surgeries
Preparation for surgical treatment
Preparing cosmetic surgeon’s hands prior to surgical treatment
Preparation of the colon for surgical treatment
Postoperative goal pneumonia in neurosurgical and thoracic operations
Postoperative queasiness
Postoperative bleeding
Postoperative Granuloma
Postoperative shock
Early postoperative duration
Myocardial revascularization
Root pinnacle resection
Resection of the stomach
Bowel resection
Uterus resection
Liver resection
Small bowel resection
Gastric resection
Reclusion of the ran vessel
Bonding of tissues throughout surgical interventions
Stitching
Condition after eye surgical treatment
Condition after surgical treatment
Condition after surgical treatment in the nasal cavity
Condition after gastrectomy
Condition after resection of the little intestinal tract
Condition after tonsillectomy
Condition after elimination of the duodenum
Condition after phlebectomy
Vascular surgical treatment
Splenectomy
Sterilization of a surgical instrument
Sterilization of surgical instruments
Sternotomy
Dental surgical treatment
Dental intervention on gum tissues
Strumectomy
Tonsillectomy
Thoracic surgical treatment
Thoracic surgical treatment
Total gastrectomy
Transdermal Intravascular Coronary Angioplasty
Transurethral resection
Turbinectomy
Removal of a tooth
Cataract elimination
Cyst elimination
Tonsil Removal
Fibroid elimination
Removal of mobile milk teeth
Polyp elimination
Tooth extraction
Removal of the uterus
Stitch elimination
Urethrotomy
Fistula of cerebrospinal fluid courses
Frontoetmoidogymorotomy
Surgical infection
Surgical treatment of persistent limb ulcers
Surgery
Surgery in the rectum
Colon surgical treatment
Surgical practice
Surgical treatment
Surgical interventions
GI Surgery
Urinary Surgery
Urinary Surgery
Genitourinary surgical treatment
Heart Surgery
Surgical treatments
Surgery
Vein surgical treatment
Surgical intervention
Vascular surgical treatment
Surgical treatment of apoplexy
Surgery
Cholecystectomy
Partial gastrectomy
Peritoneal Hysterectomy
Percutaneous transluminal coronary angioplasty
Percutaneous transluminal angioplasty
Coronary artery bypass grafting
Tooth extirpation
Extirpation of milk teeth
Pulp extirpation
Extracorporeal flow
Tooth extraction
Tooth extraction
Cataract extraction
Electrocoagulation
Endourological interventions
Episiotomy
Ethmoidotomy
Z72.0 Tobacco UseSmoking
Smoking
Z95.1 Presence of coronary artery bypass graftCoronary artery bypass implanting with venous shunt
Coronary artery bypass grafting
Z95.5 Presence of coronary angioplastic implant and transplantArteriovenous bypass
Arteriovenous Shunt Thrombosis
Coronary artery bypass grafting
  • as a preventive treatment for diabetes mellitus, weight problems, smoking cigarettes, hyperlipidemia, the senior (from aging) to avoid the event of myocardial infarction;
  • an indicator for the use of the drug is a propensity to the event of deep vein apoplexy, thromboembolism;
  • avoidance after operations on the arteries and heart;
  • signs for use are likewise the avoidance of circulatory conditions of the brain and stroke.
  • a contraindication to the use of the drug is a drug allergic reaction;
  • diathesis;
  • asthma
  • liver and kidney illness;
  • intense cardiac arrest.
  • Acute migraine attack;
  • Rheumatic illness;
  • Fever accompanying transmittable and inflammatory illness;
  • Pain syndrome of numerous origins.
  • Bronchial asthma, provoked by the use of salicylates and non-steroidal anti-inflammatory drugs;
  • Erosive-ulcerative illness of the intestinal system in the intense stage;
  • Hemorrhagic diathesis;
  • The synchronised use of aspirin with methotrexate with a weekly dosage of 15 mg;
  • I and III trimesters of pregnancy;
  • Age approximately 15 years;
  • Hypersensitivity to salicylates.

Overdose

A single dosage of Aspirin is taken 3 times a day, the period in between dosages is 4-8 hours. Patients with impaired liver and kidney function need to either increase the period in between dosages or decrease the dosage.

In case of fever, discomfort, rheumatic illness, a single dosage for grownups and kids over 15 years of ages is 0,5-1 g (day-to-day dosage – no greater than 3 g).

Tablets must be taken after meals, swallowed entire and cleaned down with water.

The use of Aspirin must not last more than 3 days as an antipyretic, more than a week – as an analgesic.

An overdose of Aspirin of moderate seriousness appears by signs such as clouding of awareness, headache, lightheadedness, queasiness, throwing up, hearing loss, ringing in the ears. In most cases, they vanish with a decline in the dosage of the drug.

For an extreme overdose of the drug, such symptoms as serious hypoglycemia, breathing failure, hyperventilation, fever, cardiogenic shock, breathing alkalosis, ketosis, metabolic acidosis, coma are particular.

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In the case of taking Aspirin in really high dosages, the client is hospitalized. It is advised that you take triggered carbon and continuously screen the acid-base balance, in addition to alkaline diuresis, which is performed till the urine pH remains in the variety of 7,5–8 [forced alkaline diuresis is considered effective if, as a result of the procedure, the salicylate content in the blood exceeds 500 mg/l (3,6 mmol/L) in adult patients and 300 mg/L (2,2 mmol/L) in children]. If needed, lavage and hemodialysis sessions are carried out. Treatment procedures likewise consist of symptomatic treatment and settlement for fluid shortage.

The instructions for Aspirin Cardio state that the tablets are taken orally prior to meals.

The daily dosage and period of treatment must be recommended by a physician. As a guideline, it is from 100 to 300 mg each day.

To avoid illness of the heart and capillary of the brain, from aging, the drug is recommended in a quantity of 100 mg each day. If you missed out on taking a heart Aspirin tablet, you must take it as quickly as possible, other than when it is time for the next one.

Dyspepsia, visual problems, headache. Treatment according to signs. Gastric lavage, enterosorbents, laxatives. Blood pH ought to be kept track of, if the indication moves towards an acidic environment, then salt bicarbonate is presented into the blood.

According to the instructions, the signs of an overdose of moderate seriousness are queasiness, throwing up, hearing loss, ringing in the ears, confusion, lightheadedness, discomfort in the head. They disappear at a lower dosage. Signs of an extreme overdose are fever, breathing alkalosis. The client might reveal coma, cardiogenic shock, serious hypoglycemia, metabolic acidosis and breathing failure.

Overdose treatment is necessary hospitalization of the client, lavage (cleaning of contaminants by the intro of an unique option), taking activated carbon, alkaline diuresis to get particular specifications of urine level of acidity. In case of fluid loss, hemodialysis is performed for the client, procedures for its settlement.

Inside, it is recommended to take a minimum of 30 minutes prior to meals, drinking plenty of water, 1 time each day or every other day. To guarantee the release of ASA in the alkaline environment of the duodenum, tablets must not be squashed, squashed or chewed.

ASPIRIN® CARDIO is planned for long-term use. The period of treatment is identified by the medical professional.

Primary avoidance of intense myocardial infarction in the existence of danger aspects. 100 mg/day or 300 mg every other day.

Prevention of frequent cardiovascular disease, steady and unsteady angina pectoris. 100-300 mg/day.

Unstable angina (with presumed advancement of intense myocardial infarction). The preliminary dosage of 100-300 mg (the tablet need to be broken, squashed or chewed for much faster absorption) ought to be taken by the client as quickly as possible after there is a suspicion of the advancement of intense myocardial infarction.

Prevention of stroke and short-term cerebrovascular mishap. 100-300 mg/day.

Prevention of thromboembolism after surgical treatment and intrusive vascular interventions. 100-300 mg/day.

Prevention of DVT and lung embolism and its branches. 100-200 mg/day or 300 mg every other day.

Actions to avoid taking several dosages of a drug. You must take the missed out on tablet as quickly as the client remembers this, and after that continue taking it as typical. To prevent doubling the dosage, do not take the missed out on tablet if the time for taking the next tablet is approaching.

Features of the action of the drug at the initially dosage and when it is canceled. There were no particular functions of the action of the drug at the initially dosage and its withdrawal.

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Children. The security and efficiency of the use of ASPIRIN® CARDIO in kids and teenagers under the age of 18 has actually not been developed. The use of the drug in clients under 18 years of age is contraindicated.

Impaired liver function. ASPIRIN® CARDIO is contraindicated in clients with significantly impaired liver function. Use the drug with care in clients with impaired liver function.

Impaired kidney function. ASPIRIN® CARDIO is contraindicated in clients with serious kidney problems. Use the drug with care in clients with impaired kidney function, given that its use can increase the danger of establishing kidney failure and intense kidney failure.

Salicylate intoxication (establishes when taking ASA at a dosage of more than 100 mg/kg/day for more than 2 days) might arise from extended use of poisonous dosages of the drug as part of inappropriate restorative use (persistent intoxication) or a single unexpected or deliberate administration of a harmful dosage of the drug to grownups or kid (intense intoxication).

Symptoms of persistent intoxication with salicylic acid derivatives are nonspecific and frequently hard to detect. Mild intoxication generally establishes just after duplicated use of big dosages of the drug and appears by lightheadedness, vertigo, ringing in the ears, hearing loss, increased sweating, queasiness and throwing up, headache and confusion.

The primary symptom of intense intoxication is an extreme infraction of the acid-base state, the symptoms of which might differ depending upon the age of the client and the seriousness of intoxication. In kids, the most common is the advancement of metabolic acidosis. Since the absorption rate of ASA might reduce due to postponed stomach emptying, the development of calculi, or the use of drugs resistant to the intestinal juice, it is difficult to judge the seriousness of intoxication just by altering the concentration of salicylates in the blood plasma.

Symptoms of an overdose from moderate to moderate: tachypnea, hyperventilation, breathing alkalosis; extreme sweating; queasiness, throwing up; lab and important information: alkalemia, alkaluria.

Symptoms of an overdose from moderate to serious: breathing alkalosis with offsetting metabolic acidosis; hyperpyrexia (very high body temperature level); breathing conditions (hyperventilation, non-cardiogenic lung edema, breathing anxiety, asphyxia); conditions from the CCC (heart rhythm disruptions, arterial hypotension, inhibition of heart activity);

infraction of the water-electrolyte balance (dehydration, impaired kidney function from oliguria approximately the advancement of kidney failure); impaired glucose metabolic process, ketosis; ringing in the ears, deafness; intestinal bleeding; hematological conditions (from inhibition of platelet aggregation to coagulopathy);

neurological conditions (poisonous encephalopathy and anxiety of the main nerve system (sleepiness, confusion, coma, convulsions); lab and important information: acidemia, aciduria, modifications in high blood pressure, ECG, hypokalemia, hypernatremia, hyponatremia, impaired kidney function, hyperglycemia, hypoglycemia (specifically kids), ketoacidosis, extending of PV, hypoprothrombinemia.

Treatment of overdose from moderate to moderate seriousness: stomach lavage, duplicated administration of triggered charcoal, required alkaline diuresis; repair of water-electrolyte balance and acid-base state.

Medium to serious overdose treatment: stomach lavage, duplicated administration of triggered carbon, required alkaline diuresis; in serious cases – hemodialysis; repair of water-electrolyte balance and acid-base state.

Analogues

According to the active compound of the structure, medicinal action in relation to the body, the following Aspirin analogues, produced by domestic and foreign business, are differentiated:

  • Thrombotic ACC;
  • Acecardol;
  • Ibuprofen;
  • Anti-influenza caps;
  • Aspeter
  • Citramon;
  • Aspicode
  • Asprovit;
  • Acecardin;
  • Acelisinum;
  • Copacil;
  • Paracetamol.

Analogues of Aspirin are: ASA-Cardio, Uppsarin Upsa, Acetylsalicylic acid, Aspicor, Aspinat, Acekardol, Taspir, Thrombo ACC, Sanovask, etc.

Detonic – a unique medicine that helps fight hypertension at all stages of its development.

Detonic for pressure normalization

The complex effect of plant components of the drug Detonic on the walls of blood vessels and the autonomic nervous system contribute to a rapid decrease in blood pressure. In addition, this drug prevents the development of atherosclerosis, thanks to the unique components that are involved in the synthesis of lecithin, an amino acid that regulates cholesterol metabolism and prevents the formation of atherosclerotic plaques.

Detonic not addictive and withdrawal syndrome, since all components of the product are natural.

Detailed information about Detonic is located on the manufacturer’s page www.detonicnd.com.

Tatyana Jakowenko

Editor-in-chief of the Detonic online magazine, cardiologist Yakovenko-Plahotnaya Tatyana. Author of more than 950 scientific articles, including in foreign medical journals. He has been working as a cardiologist in a clinical hospital for over 12 years. He owns modern methods of diagnosis and treatment of cardiovascular diseases and implements them in his professional activities. For example, it uses methods of resuscitation of the heart, decoding of ECG, functional tests, cyclic ergometry and knows echocardiography very well.

For 10 years, she has been an active participant in numerous medical symposia and workshops for doctors - families, therapists and cardiologists. He has many publications on a healthy lifestyle, diagnosis and treatment of heart and vascular diseases.

He regularly monitors new publications of European and American cardiology journals, writes scientific articles, prepares reports at scientific conferences and participates in European cardiology congresses.

Detonic