MCHC is the average concentration of hb in red blood cells. Reflects the degree of saturation of all red cells of the body with hemoglobin. The hemoglobin molecule is a complex substance, consists of a protein part and iron. Its main function is transport, it carries oxygen, saturating it with organs and tissues.
With iron deficiency, hypoxia develops in the body – oxygen starvation. In a healthy adult body, the described indicator is stable and has a constant value. A wider range in mchc blood in children, which is associated with the formation of the hematopoietic system.
To study mchc in a blood test, capillary blood is taken, that is, from the finger. To get the right result, you need to follow a few simple rules:
- The analysis is given on an empty stomach, the minimum break between meals should be 8-10 hours.
- Before the test, you can drink plain water.
- Stop smoking, drinking alcohol, active sports should be at least a day before the analysis.
The indicator is calculated by a special formula. It is necessary to divide hemoglobin (g / l) * 100 into hematocrit. The measurement is carried out in grams / liter (g / l). The values of the norm are:
- 320-365 g / l in men;
- 320-355 g / l in women;
- up to 380 g / l in children under 5 years.
MCHC: calculation formula, blood norm
Laboratories often use the average value for people of both sexes, it is 320-380 g / l. In addition to children, the indicator varies slightly in the elderly. They are characterized by its decrease, which is associated with a decrease in bone marrow activity. This means a decrease in the number of red blood cells and their indices.
In the diagnosis of diseases, a general blood count plays an important role. Based on a change in its indicators, it can be assumed what process takes place in the body, how it develops and what its causes are.
The MCH and MCHC values in the blood test indicate the average hemoglobin (Hb) content, and their deviations may indicate significant changes in the structure of the bone marrow and red blood cells. Today you will learn how they are determined, what causes them to change, and how decryption is performed.
The average concentration of hemoglobin in the blood
MCH (decoding – mean concentration hemoglobin) – an indicator showing the average content in a particular red blood cell Hb. It can be obtained by dividing the total hemoglobin by the erythrocyte count.
The norm of this indicator is 24-35 pg. In children, its amount may be slightly different, and vary at one or another age.
The change occurs as a result of the action of various factors, as a result of which the average value of the blood color index changes, based on which the diagnosis of one or another anemia is determined.
MCHC (stands for mean corpuscular hemoglobin concentration) is an average value showing the Hb content in red blood cells. It is usually used to refine MCH, since if a change in MCH is observed in red blood cells, then the MCHC should also change proportionally.
The norm of MCHC in red blood cells is 300-380 g / l.
Both indicators make it possible to judge the changes occurring in each individual red blood cell. Any change in red blood cells indicates a pathology of the blood system, and, accordingly, that appropriate treatment is necessary. Diagnose their change allows a general blood test (that is, its decoding with an indication of all possible indicators).
Decryption of the analysis is carried out by a laboratory assistant or directly attending physician.
Hypotheriosis is one of the reasons for increasing the color index
What reasons affect the change in these indicators, and what does their increase mean?
MCH is increased if the concentration of hemoglobin in a single red cell increases (the color index becomes more than 1,1). Such a change can be with such diseases:
- Anemia. Among them, hyperchromic (saturated Hb) and megaloblastic (in the case when the formation of large-sized cells occurs) come first. In this case, the normal transport function of the blood is violated (due to an increase in the amount of hemoglobin), blood circulation in the small vessels of the organs worsens, which affects their functional activity. Despite the fact that the level of Hb is increased, the cells are defective and die quickly.
- Hypothyroidism A low thyroid hormone content helps to reduce bone marrow activity. As a result of this, the hemoglobin concentration increases, which leads to the fact that the color index is increased.
- Liver disease. As you know, this particular organ is responsible for the synthesis of most protein molecules (in addition, their number is increased both in the organ itself and in the internal environment). This is especially noticeable if hypertrophy or an oncological process develops in the liver (the level of synthesis in the tumor tissue is increased). As a result, the concentration of red blood cells and their level are increased, they all have a larger volume of Hb and, accordingly, a color indicator. Women are less common than men.
- Oncological diseases. The pathology of the red bone marrow, as well as the stomach and lungs can lead to significant changes in red blood cells and, as a result, MCH will be increased. In both children and adults, a deviation from the norm of MCH and MCHC due to oncology is observed in the case of leukemia, while the index of each index can be tens of times higher than its norm.
In fact, it is not so bad if the level of MCH or MCHC is slightly increased. This suggests that the blood more or less copes with its function. Much worse if their rate is lowered.
Heredity is one of the reasons for hemoglobin production disturbance
A decrease in MCH and MCHC can also lead to various metabolic disorders, as the oxygen content in the blood decreases, perfusion of the cells decreases and, as a result, the state of internal organs deteriorates, which can lead to their dysfunction. This is especially dangerous for pregnant women and children, since a small amount of hemoglobin will negatively affect both the condition of the fetus and the processes of laying its tissues, as well as on the growing body.
Reasons for MCH and MCHC to be lowered:
- reduced concentration of iron in the body (its norm in the blood is about 5 mg). Usually, its content decreases with internal bleeding, diseases of the gastrointestinal tract, as well as its inadequate level in incoming food. As a result, due to the fact that the iron index is lowered, full hemoglobin cannot be synthesized, which manifests itself in the form of iron deficiency anemia. It is observed mainly in women, since the physiology of their body suggests a monthly loss of iron (which is why it is necessary to maintain its content in the blood);
- hereditary blood diseases (for example, thalassemia) – manifests itself mainly in children. With them, there is a violation of the production of structural units of hemoglobin – protein chains (mainly alpha). Hb carrying these chains cannot adequately supply oxygen to cells and organs. It is possible to identify such a disease already in the first years of a child’s life and take appropriate measures to eliminate them;
- lack of vitamin B6. This vitamin, like all the others from group B, is responsible for many metabolic processes (its norm is about 2 mg, and its content in the blood is constantly changing). Especially, this concerns the bone marrow, where the formation of most blood cells, as well as hemoglobin, occurs. If its concentration decreases, the process of connecting the Hb polypeptide chains is disrupted, which leads to the fact that MCH and MCHC are reduced. In women, this condition is somewhat more common than in men.
All of these reasons have a significant effect on the state of the blood system and lead to a decrease in the color index and a decrease in hemoglobin in red blood cells. In order to prevent their change, you need to know about possible preventive measures.
The rate of indicators can progressively decrease with age, so you should not panic greatly when they decrease in the elderly.
A healthy lifestyle helps restore normal rates
What is necessary to prevent changes in these indicators and how to prevent their main causes?
First of all, remember to respect a healthy lifestyle. Daily exercise, proper and balanced nutrition will help to restore normal rates.
It is especially important to pay attention to a properly selected diet, in which the content of essential amino acids and molecular iron is increased.
These products include pomegranate, liver, some seafood, as well as apples.
In pregnant women, the content of incoming iron should be increased (especially during the first and half of the second trimesters), since it is also necessary for the growing fetus.
Also, throughout the pregnancy, multivitamin complexes are indicated (especially in women with trophic disorders). For timely diagnosis, they are shown a general blood test (every month before pregnancy and for 4-5 months after conception).
Prevention of a decrease in indicators in children is recommended from the very birth (especially with complicated heredity).
Doctors need to carry out preventive work among the population, especially among women. It is extremely important to eliminate all exogenous causes of a decrease in erythrocyte indices, since often this allows faster restoration of their norm.
The norm of MCH and MCHC suggests that everything is fine in the body and there is no reason for panic. In the event that their change is observed, careful observance of the doctor’s prescriptions and proper nutrition will allow you to bring the blood in order.
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