How to treat cholestatic hepatosis

Cholestatic hepatosis is characterized by the accumulation of bile pigments in hepatocytes, their trophism is disturbed, dystrophy develops, which is caused by a deficiency of protein structures. Cholestatic hepatosis occurs in every fifth pregnant woman.

During the period of gestation, the processes inside the liver cells are activated, since at this time their task is to regulate and inactivate the concentration of hormonal substances, and they must also neutralize the waste products of the fetus. Such processes can cause disturbances in liver function of various forms and severities.

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Most often, cholestatic hepatosis of pregnant women does not entail the development of serious consequences for the expectant mother or child. But in the event that dysfunctions occur in the hepatobiliary system, cholestatic hepatosis of the liver occurs.

With such hepatosis of pregnant women, the function of the cells of the organ is disrupted, and bile acids accumulate in it. Experts are sure that this pathology is congenital, and pregnancy only intensifies its exacerbation.

The risk of pathology is increased if a woman takes oral contraceptives and antibacterial drugs.

Why appears

Experts are sure that this pathology is congenital. But it is latent in many people. Only in the presence of predisposing factors do the signs of the disease appear. Such provoking factors include: a negative effect on the body of toxic substances or allergens, most often the latter are contained in medications.

With cholestatic hepatosis, disturbances in the metabolic processes of cholesterol and bile enzymes occur, and the outflow of bile worsens.

Symptoms of the disease

If liver hepatosis develops, the symptoms are pronounced. The very first clinical manifestations of the disease:

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  • Intensely pronounced itching of the epidermis.
  • Yellowness of the skin.
  • Sleep disturbances.
  • The stool becomes very light.
  • The urine becomes dark in color.
  • Temperature readings are subfebrile.
  • Painful sensations in the right iliac region.
  • Enlargement of the liver in size.

When the pathological process continues to progress, cholestasis is noted with such manifestations: disorders in the organs of the digestive system, nausea or vomiting, loss of appetite, weight loss. Usually, after childbirth, the symptoms of the disease disappear, it rarely becomes chronic or long-term. But if the woman becomes pregnant again, the disease can worsen.

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Diagnostic measures

The symptoms and treatment of the disease are closely related. Depending on the severity of the clinical picture, the doctor will prescribe treatment or limit himself only to recommendations for correcting the diet.

If the diagnosis is carried out in a timely manner, the prognosis for recovery is favorable.

The main diagnostic measures are:

  • Laboratory study of blood fluid, it is important to determine the concentration of enzymes and acids.
  • Ultrasonography.
  • Doppler ultrasonography with its help examines the fetus.
  • CTG – performed in the third trimester to establish the heart rate of the unborn child.

Features of therapy

Treatment for cholestatic hepatosis is to cleanse the organ of bile acids and restore its functions. Since the exact cause of the development of the disease is almost impossible to establish, elimination of the causes is not carried out. Only cleansing and restoration.

What drugs are used to treat:

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  • Polyphelan – blocks excessive bile production.
  • Glucocorticoids are prescribed to suppress elevated estrogen levels.
  • To cleanse and restore the work of the organ, hepatoprotectors are prescribed – Karsil, Essentiale, Enerliv.
  • Vitamins, multivitamin complexes.
  • Herbal medicines – Galstena, Gepabene.
  • Medicines for the outflow of bile – Ursosan.

A prerequisite is a diet, which is to minimize the use of fatty foods, sweets, alcoholic beverages, smoked and pickled foods. With this diet, you can reduce the burden on the liver.

If all medical recommendations are followed, this disease can be overcome without harm to the health of the expectant mother and her baby.

Preventive measures

It is very important to exclude predisposing factors for the possible development of the disease. For this, a diet is recommended before and during pregnancy. One of the prerequisites for prevention is the intake of hepatoprotective drugs prescribed by a doctor. You should not use any medications on your own, only after preliminary consultation with a doctor.

It is important to observe proper nutrition, timely treatment of diseases of the digestive system. If there is a history of such a pathology as fatty hepatosis, it is very important to systematically visit the treating doctor and undergo all the necessary examinations. Undergo treatment courses at least once a year.

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Svetlana Borszavich

General practitioner, cardiologist, with active work in therapy, gastroenterology, cardiology, rheumatology, immunology with allergology.
Fluent in general clinical methods for the diagnosis and treatment of heart disease, as well as electrocardiography, echocardiography, monitoring of cholera on an ECG and daily monitoring of blood pressure.
The treatment complex developed by the author significantly helps with cerebrovascular injuries and metabolic disorders in the brain and vascular diseases: hypertension and complications caused by diabetes.
The author is a member of the European Society of Therapists, a regular participant in scientific conferences and congresses in the field of cardiology and general medicine. She has repeatedly participated in a research program at a private university in Japan in the field of reconstructive medicine.