Creatine kinase in the blood causes of increase and normalization methods

Of great concern is the jump in this enzyme in young children, since its normal rates are already quite high. The reasons that creatine kinase is elevated in a child may include:

  • all kinds of injuries;
  • previous surgical interventions;
  • pathologies associated with the central nervous system;
  • excessive physical activity.

If the creatine kinase MV in a child is increased, this can indicate serious violations in the work of the heart. Congenital or acquired heart defects are the most common causes of increased levels of this KK-MV in young children. Such a deviation is extremely dangerous, therefore it is impossible to ignore the problem – further predictions for recovery depend on when treatment was started.

Another reason why blood CPK levels can be elevated is a dangerous disease such as tetanus. Alas, cases of infection with this dangerous pathology have recently become more frequent. The disease has an extremely difficult clinical picture and can lead to death, therefore it is extremely important to take all measures to prevent its development.

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What is KFK?

With the increasing awareness of the population about medicine and their own health, more and more people are turning to Internet portals to decrypt their blood tests. In this article, we will take another step towards the enlightenment of citizens and talk about such an aspect of biochemical analysis as creatine phosphokinase or CPK.

Creatine kinase or creatine phosphokinase is one of the enzymes that make up the cells of the brain, heart, muscle tissue, thyroid gland, pulmonary membranes, nervous and other equally important body systems. An increase in the level of Kfk in the blood may indicate the destruction of cells and the release of this enzyme into the blood, which can be caused by the most serious reasons.

A blood test for CPK is usually prescribed for suspected life-threatening conditions, such as acute myocardial infarction, cancer, pathologies of the human skeletal system. The doctor can prescribe a blood sampling for CPK in the event that a person has suffered severe muscle injuries, tears, sprains, etc.

The procedure is carried out in special laboratories or hospital facilities, since a blood test in a regular clinic is difficult due to the complexity of the operation. Using a syringe, a nurse draws a patient’s venous blood, after bandaging her hand with a tourniquet.

So, if the doctor, for some reason, prescribed you a venous blood test for creatine kinase, it is recommended that the following points be observed to avoid secondary testing:

  • Firstly, blood donation is performed exclusively on an empty stomach. It is advisable not to eat 8 hours before the procedure;
  • Tell your doctor about your medication. Some drugs can trigger increased enzyme production;
  • Remove spicy and fatty foods, tobacco products, alcohol (and even kvass) from the diet at least a day before the analysis;
  • After x-rays and other studies of the body through rays and ultrasound, it is recommended to wait at least a week before the procedure.

Despite the fulfillment of the above points, the doctor in any case will prescribe you a re-analysis if something is wrong with the results of the first.

The level of CPK may vary depending on gender, age, physique and other factors, but in most cases it does not exceed 200 u/l.

A detailed layout by gender/age looks like this:

  • Up to a week (newborns) – up to 540 units/l;
  • Kids up to six months – up to 300 units per liter;
  • From 1 year to 3 years – 230 units/l;
  • 3-6 years: up to 150 units per liter;
  • Girls from 6 to 12 years old – 154 units/l;
  • Boys from 6 to 12 years old – 250 units/l;
  • Girls from 12 to 17 years old – 123 units;
  • Boys from 12 to 17 years: 270 units/liter.

As you can see, from the age of 6, an inter-gender difference in this indicator begins to appear. After 17 years, it will be approximately 60 units:

  • Girls/women: 167 units/l;
  • Boys/men: 195 units/l.

Since CPK or creatine phosphokinase is one of the elements that make up muscle tissue, its blood level is directly proportional to the amount of muscle mass. That is why in men this parameter is on average higher than in women. A high level of CPK in infants is due to the absence of a formed blood-brain barrier.

If the conditions for the analysis were met, blood sampling was performed twice, and the result is still positive, it is worth thinking about the reasons that provoked this phenomenon. Here are all the possible catalysts:

  • Serious injury with damage to muscle fibers;
  • Mental illnesses such as schizophrenia or epilepsy;
  • Malignant tumors;
  • Damage to the heart muscle as a result of myocardial infarction;
  • Weakening of the functions of the thyro >kreatinkinaza v krovi - Creatine kinase in the blood causes of increase and normalization methods

As you can see, the list of possible causes is not the most rosy, which is why it is so important to consult a doctor as soon as possible for early diagnosis and prevention of the development of certain diseases, as well as for the appointment of appropriate therapy.

Professional athletes and bodybuilders must include creatine in their diet to increase their results. Studies show that taking creatine improves athletic performance by up to 20%! This is because creatine is urgently needed by the muscles for their normal functioning, in particular for the synthesis of CPK creatine kinase, which is part of ATP – the energy “storage” of muscles.

Many will wonder: how to prevent an increase in the level of Kfk in the blood and what to do if this has already happened? The answer is simple – to deal with the cause of the pathology, which most often appears due to an improper lifestyle. Below we will give some recommendations that will help keep the indicator normal.

First of all, you should think about the correctness and balance of your diet: consume more fatty acids, omega-6, omega-3, etc., foods of plant origin, that is, vegetables and fruits.

Along with this, limit the intake of fatty and spicy and salty foods, as they can lead to cardiovascular diseases that provoke the growth of Kfk in the blood.

The next step should be the regulation of physical activity – during training do not take action, monitor the regime of work and rest, provide the muscles with normal relaxation, do warm-ups before classes – and there should be no problems. If you are professional, you should consider using creatine-containing drugs.

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The normal level of creatine kinase starts from 0, that is, in the normal mode of functioning of the body, it should be at least in the blood. Doctors in this case talk about the low diagnostic significance of the phenomenon – that is, even if CPK is absent in the body, then everything is fine with you – this can happen due to pregnancy, vitamin C intake, decreased muscle mass, etc.

Kfk in the blood

Creatine phosphokinase or CPK is an enzyme that is part of muscle tissue, brain, heart muscle, nervous and other systems.

In blood, its content should be minimal – up to 200 units per liter.

Increased values ​​may indicate the presence of serious diseases – you should consult a doctor for examination, and also lead a healthy lifestyle; lowered are not diagnostically significant.

A biochemical blood test allows you to identify abnormalities in the functioning of internal organs and diagnose diseases at an early stage of development. During the study, the amount of proteins, enzymes, lipids, glucose, and the state of nitrogen metabolism are determined.

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One of the bioelements of the analysis is creatine kinase (otherwise, creatine phosphokinase), the level of which assesses the energy potential of the entire muscle apparatus of the body, including the myocardium (heart muscle), and nerve tissue of the brain. If the creatine kinase in the blood is elevated, this indicates the destruction of the cellular structure of muscle tissue.

Creatine phosphokinase is an enzyme that accelerates the biochemical transformation of creatine and adenosine triphosphate into creatine phosphate. In the process of this transformation, energy impulses are amplified, providing full muscle contraction.

CPK contains two component molecules (B and M), which in different combinations form three isoenzymes, each of which is localized in a specific structure of the body and is responsible for its neuromuscular functionality. KFK isoenzymes:

  • MM – isoenzyme of skeletal muscle cells (myocytes);
  • VM – isoenzyme of muscle fibers of the myocardium and skeletal muscle;
  • BB is an isoenzyme of nerve tissue in the brain.

CPK-BB is found in the blood only with vascular or brain pathologies. In a healthy state of the body, an isoenzyme is unable to cross the barrier between the circulatory and central nervous systems (the blood-brain barrier). CPK VM is an indicator of contractions of the heart muscle and the main diagnostic indicator of myocardial infarction. CPK MM accounts for 98% of all creatine kinase.

Reference! The second name for creatine kinase – CPK, or creatine phosphokinase, comes from the name of the biochemical process of correlation of creatine and adenosine triphosphate – phosphorylation.

A blood test for CPK can be assigned separately or as part of a biochemical study of a biological fluid (blood) to evaluate all indicators. Emergency blood microscopy at the level of creatine phosphokinase is performed for acute pain in the heart and behind the sternum, radiating under the scapula, in the forearm and shoulder on the left side.

If a sharp increase in CPK is observed against the background of pain symptoms, then myocardial integrity is impaired. In 100% of cases, a heart attack or pre-infarction condition is diagnosed. Increased attention to CPK in the biochemical analysis of blood is given in the initial diagnosis and treatment of the following diseases:

  • myositis – inflammation of the muscle fibers of the skeleton of various locations (neck, chest, back, etc.);
  • myopathy (chronic neuromuscular pathology);
  • inflammatory heart diseases (pericarditis, myocarditis, endocarditis, etc.);
  • CHD (coronary heart disease);
  • hypothyro >c4097f30eb9614ddda7ae42edc445e2e - Creatine kinase in the blood causes of increase and normalization methods

The reasons why creatine phosphokinase in the blood is increased can be either pathological or non-pathological in nature. Let’s consider them separately.

Pathological reasons for increasing CPK include:

  1. The development of hypothyroidism. A similar violation in the functioning of the thyroid gland is found, as a rule, in women, especially those who are “in an interesting position”. But such a deviation can also affect the male body, although much less often.
  2. Another reason that creatine phosphokinase in the blood is elevated is hypokalemia, which occurs in severe form. In this case, there will be a significant violation of the skeletal muscle, so the study on CPK is extremely important for making the correct diagnosis.
  3. Some reasons for the increase in CPK in the blood are directly related to impaired brain function. In particular, similar deviations are noted with epilepsy, mental illness, damage to GM by pathogenic bacteria, etc.
  4. Cardiac pathologies are one of the most common causes of increased CPK. The patient’s complaints should indicate a biochemical blood test of the doctor’s blood, indicating abnormal functioning of the heart muscle: shortness of breath, tachycardia, dizziness, pain behind the sternum.
  5. High creatinase may indicate the development of a tumor process in the body.

Relatively safe, that is, non-pathological factors that can cause an increase in CPK indicators are:

  1. Alcohol intoxication. This refers to a significant excess of the permissible dosages of alcohol.
  1. One of the reasons that creatine phosphokinase is elevated in adults is a course of intramuscular injection. With this introduction of drugs, the body experiences severe stress, as a result of which CPK values ​​increase significantly.
  2. After an operation with dissection of muscle fibers or entire muscle groups, creatinase can be increased in the blood until the wounds heal a bit and the body recovers after surgery.
  3. In people who are professionally involved in sports aimed at building muscle, this enzyme can also jump. Therefore, athletes should not look for the pathological causes of a high level of CPK in the blood, especially if they additionally use intramuscular injections to accelerate muscle growth.

Be that as it may, you cannot joke with such a deviation – it is better to go through additional studies to make sure that there are no serious health problems. There are many reasons for the increase in CPK in the blood, so it’s almost impossible to independently find the one that caused the patient’s malaise.

Creatine kinase acts as a catalyst in biochemical reactions, it is necessary for energy metabolism in tissues, to maintain their tone and to carry out muscle contractions.

The current state of muscle systems is determined by the amount of this enzyme in the blood.

When muscles are damaged, CPK from muscle cells enters the bloodstream, respectively, its level increases.

According to the results of this study, the doctor can also find out the nature and degree of tissue damage.

Most often, the doctor directs for an analysis to accurately determine such a dangerous diagnosis as myocardial infarction, as well as for the diagnosis of a heart attack. Thanks to this testing, such diagnoses are detected with an accuracy of 100%.

According to the results of the analysis, one can judge the causes of pain in the chest, the state of the heart muscle and skeletal muscles.

The study is also conducted to identify possible diseases at an early stage or to test the effectiveness of treatment of an existing diagnosis.

In general, this procedure requires the same preparation as most blood tests. The fence is made early in the morning. Before going to the hospital you can’t have breakfast, go on an empty stomach, and 2 hours before visiting you can’t smoke.

Important! Before taking an analysis for CPK, you should not drink alcohol, take a number of drugs, in particular lowering cholesterol.

If you can’t refuse to take the medicine, be sure to notify the doctor. Tell him the name of the drug to be taken and its dosage.

All these actions can lead to an increase in the content of creatine phosphokinase in the blood, and the results will be unreliable.

Blood is drawn from a vein at the elbow, just like for other similar tests. After that, the collected material is sent to the research laboratory for study.

For the study, it is necessary to separate the serum from the cells. The analysis procedure is carried out using a special device KFK-photocolorimeter.

The apparatus is based on the photometry method: there is a selective absorption of electromagnetic radiation in the visible (infrared and ultraviolet) spectrum.


The level of CPK is measured in units/liter. (unit of enzyme per liter of serum)

Indicators KFK norms in people of different ages vary. The enzyme activity is naturally higher in children, since they actively grow and develop, move more, all biochemical processes in them pass much faster. Also, in men, the CPK level is higher than in women. The indicator depends on the level of physical activity: the more people engage in sports, the more active the enzyme.

Attention! There are certain norms for the content of CPK in the blood for each group of individuals: the total value of the norm is 24-195 U/l; for men over 17 years of age, 190 Units/L is considered optimal, for women over 17 – 167 Units/L.

  • heart disease, myocardial infarction, and heart attacks;
  • myodystrophy of any type;
  • the presence of diseases such as heart failure, tachycardia, tetanus;
  • disorders of the central nervous system: schizophrenia, psychosis and various disorders;
  • excessive physical activity and muscle injuries associated with them;
  • various surgical interventions, as well as the postoperative period;
  • inflammatory processes in the body;
  • cancers;
  • abuse of alcohol and sleeping pills.

A decrease in enzyme activity indicates insufficient physical activity, a sedentary lifestyle. The percentage of muscle mass in the body decreases, which leads to insufficient production of creatine kinase. However, a low level of the enzyme does not lead to serious disturbances in the functioning of organs, therefore, the upper limit of the norm is most often indicated in the tables.

The amount of CPK is affected by the activity of the thyroid hormone secreted by the thyroid gland. With a lack of thyroxine, the level of creatine kinase can exceed the norm by tens of times, and vice versa, if there is excessive release of thyroxin, it will inhibit the activity of CPK and reduce its level.

With a high content of the enzyme in the blood, it is necessary to go to the hospital with the help of doctors, since only they can find out the cause of any deviations and prescribe the correct treatment.

However, there are still a few rules that will help stabilize the level of CPK:

  • try to eat heart-strengthening foods;
  • consume a sufficient amount of magnesium, this will help to avoid muscle cramps;
  • include in your diet foods that contain enough vitamins A and C;
  • try some types of special diets after consulting with your doctor in advance;
  • reduce the consumption of fatty, spicy and salty foods, as this adversely affects the work of the heart;
  • avoid stressful situations, try to be less nervous and overwork;
  • engage in mild physical activity is only on the recommendation of a doctor;

If KFK indicators are below normal, then just try to lead a more active lifestyle, move more, start jogging.

Conclusion: the analysis of blood CPK helps doctors diagnose very dangerous diseases at an early stage, as well as monitor the course of the disease and the effectiveness of its treatment.

A study on the activity of this substance is extremely important: it is a signal of significant violations in the body. If you suspect a malfunction in the heart or muscle system, immediately seek help from specialists and conduct an analysis on the level of CPK.

Blood CPK is an enzyme involved in the formation of energy for muscle contraction. Normally, his blood level is low (up to 200 units/liter in adults), but with muscle damage, it increases by 3-30 times. This symptom makes it possible to identify signs of myocardial infarction by blood tests already in the first hours of its development, the determination of MV-KFK is especially informative.

In children, creatine kinase is increased with hereditary muscle weakness (myopathy), myocarditis. At any age, high rates are with trauma, physical overload, tumors, hypothyroidism. In order not to get a false result, it is important to stop training for 3 days, give up alcohol.

Kfk blood: what is it

Blood CPK is the level of the creatine phosphokinase enzyme, which is responsible for generating energy. The analysis shows the destruction of muscle tissue in diseases of the skeletal muscles (myopathy, myasthenia gravis), injuries, and high-intensity training.

Activity increases with myocardial infarction, which is used in laboratory tests, an informative study of the creatine kinase MV fraction (isoenzyme). In a child, the determination of CPK is necessary for suspected myocarditis, hereditary muscle diseases, tumors, and thyroid damage. A cardiologist, endocrinologist, oncologist, neuropathologist directs the analysis.

Svetlana Borszavich

General practitioner, cardiologist, with active work in therapy, gastroenterology, cardiology, rheumatology, immunology with allergology.
Fluent in general clinical methods for the diagnosis and treatment of heart disease, as well as electrocardiography, echocardiography, monitoring of cholera on an ECG and daily monitoring of blood pressure.
The treatment complex developed by the author significantly helps with cerebrovascular injuries and metabolic disorders in the brain and vascular diseases: hypertension and complications caused by diabetes.
The author is a member of the European Society of Therapists, a regular participant in scientific conferences and congresses in the field of cardiology and general medicine. She has repeatedly participated in a research program at a private university in Japan in the field of reconstructive medicine.