After the expiration date, do not apply.
- Contraindications Methylethylpiridinol.
- Contraindications Emoxipine.
- Side effects of the components
- Side Effects of Methylethylpiridinol.
- Side effects of Emoxipine.
- Firms manufacturers (or distributors) of the drug
- Principle of operation
- General information
- Description of dosage form
- List of popular drugs divided into groups
- Essaven Gel
- Tree of pharmacological groups
- Dosing and Administration
- Side effects of the components
- Essaven Gel
(Data taken from the active ingredient Methylethylpiridinol).
• H11,3 Conjunctival hemorrhage.
• H16,8 Other forms of keratitis.
• H26 Other cataracts.
• H32,8 Other chorioretinal disorders in diseases classified elsewhere.
• H34 Occlusion of retinal vessels.
• H36,0 Diabetic retinopathy (E10-E14 with a common fourth character. 3).
• H52,1 Myopia.
• H57,8 Other unspecified diseases of the eye and adnexa.
• H59 Lesions of the eye and adnexa after medical procedures.
• I20,0 Unstable angina pectoris.
• I21,9 Acute myocardial infarction, unspecified.
• I61 Intracerebral hemorrhage.
• I63 cerebral infarction.
• L55 Sunburn.
• S06 Intracranial injury.
• T30 Thermal and chemical burns, unspecified localization.
• T88,8 Other specified complications of surgical and therapeutic interventions, not elsewhere classified.
• Z100 * CLASS XXII Surgical Practice.
• Z98,8 Other specified post-surgical conditions.
Detonic – a unique medicine that helps fight hypertension at all stages of its development.
The complex effect of plant components of the drug Detonic on the walls of blood vessels and the autonomic nervous system contribute to a rapid decrease in blood pressure. In addition, this drug prevents the development of atherosclerosis, thanks to the unique components that are involved in the synthesis of lecithin, an amino acid that regulates cholesterol metabolism and prevents the formation of atherosclerotic plaques.
Detonic not addictive and withdrawal syndrome, since all components of the product are natural.
Detailed information about Detonic is located on the manufacturer’s page.
Side effects of the components
Side Effects of Methylethylpiridinol.
Short-term agitation, drowsiness, increased blood pressure, allergic reactions (skin rashes, etc.;), local reactions – pain, burning, itching, hyperemia, densification of paraorbital tissues (resolves independently).
Side effects of Emoxipine.
Excitation (short-term), drowsiness, increased blood pressure, rash, local reactions: pain, burning sensation, itching, redness, tightening of paraorbital tissues.
Firms manufacturers (or distributors) of the drug
Principle of operation
The mechanism of action of drugs of the group of angioprotectors is not fully understood. It is clear that due to the activation of circulation in small vessels, the blood composition improves. This in turn leads to the elimination of edema, normalizes metabolism and increases vascular tone.
This group of drugs contains drugs that have different effects:
- The synthesis of hyaluronidase (enzyme) is slowed down or the activity of its secondary products is blocked.
- Eliminate stagnant processes.
- Expand blood vessels, thereby lowering blood pressure.
- Weaken the effect of prostaglandins (these are bioactive substances).
- Eliminate platelet adhesion.
- They contribute to the formation of mucopolysaccharides, which leads to an increase in the permeability of the capillary wall.
- Eliminate the adhesion of blood cells to the walls of the capillaries.
- Eliminate the signs of endothelial dysfunction – permanent and progressive damage to the inner layer of vascular cells (endothelium).
- Reduce oxidative stress – the process of cell damage due to oxidation.
- Remove inflammatory processes.
In medicine, the use of angioprotectors and correctors of blood circulation in capillaries is practiced, there are about 150 items. All these drugs are included in one subgroup of drugs for the treatment of cardiovascular diseases.
Most commonly used classification, which divides them into two categories.
This category includes drugs characterized by the content of one active component (for example, Troxerutin):
- Natural herbal preparations.
- Semi-synthetic drugs.
- Synthetic medicines.
The composition includes numerous components:
- Components that are based on the content of one or several identical active substances that are interchangeable by the effect on the body. Diosmin, hesperidin – active components. Preparations of the micronized purified fraction of flavonoids are considered the most effective for various degrees of vascular disease.
- Substances that include flavonoids from grape leaves. Production using an aqueous extract enables the drug to be well absorbed in the gastrointestinal tract.
- Proanthocyanidins or condensed tannins are powerful antioxidants that remove harmful oxygen free radicals from cells and contain grape seed extract.
- The general group of triterpenic acids.
- Needle hood.
- Ginkgo hood.
Combined drugs include Detralex, Venodiol, Antistax, Indovazin and others.
Differing in the mechanism of action, these drugs are used at various stages of venous diseases. The most studied angioprotectors are medicines from the MFF group. They show a high clinical effect during the treatment of all types and stages of pathological processes of veins.
Angioprotective drugs are divided in several directions:
- According to the form of origin (synthetic and natural plant);
- By its composition of components (mono-preparations is troxerutin and several components in a combined agent are Detralex, the drug Indovazin).
|Generation number||vasoprotectors generation number 1||generation number 2|
|drugs||Pentoxifylline angioprotector||tableted funds||injections||· Prostaglandin (alprostadil) only injection;|
|Pentilin angioprotective drug||pills||injections|
|angioprotective drug Trental||tableted funds||injections||· Vazaprostan – tablets, injections;|
|· Alprostan – tablets, injections.|
|vasoprotector Wasonite||tableted funds||· Ilomedin – tablets and injections;|
Classification of angioprotectors by pharmacological species
Angioprotectors that improve blood circulation through the smallest vessels are called microcirculatory normalizers. Their action is aimed at reducing blood viscosity (improving rheology) and reducing the resistance of the inner layer of blood vessels to its advancement. This improves blood circulation in small vessels, which account for the main load in foci with chronic microcirculatory disorders.
The general classification, types and list of drugs are given in the table.
|Active ingredient and preparations||Pentoxifylline||Pills||Injections||Prostaglandin (alprostadil) only in solution for injections|
The general list of angioprotectors includes the use of drugs based on sulodexide, troxerutin, pentoxifylline, calcium dobesylate. Plant-based angioprotectors can also be used – these are drugs that include hesperidin and diosmin.
The list of agents that have an angioprotective effect consists of drugs that have both systemic and local effects on a particular disease.
The cardiovascular system works without stopping. In this position, each link in a single complex needs an uninterrupted supply of nutrients, energy resources, and protection from harmful compounds that enter the bloodstream.
The ends of the processes of nerve fibers connect the vessels to the nervous system. When transmitting information in the form of a nerve impulse, the vessels are spasmodic or expand. The inner surface of the tubular formations produces components that stimulate the microcirculation of the blood to provide tiny vessels with biological fluid.
If there is a violation of capillary blood flow – excessive or insufficient filling of capillaries with blood, tissue hypoxia develops. Angioprotectors are prescribed to eliminate vascular failure.
Angioprotectors – drugs used to treat diseases of the cardiovascular system in complex therapy. For this task, microcirculation correctors are also used. Problems of blood inflow and outflow in small capillaries entail swelling of the tissues, venous congestion, expansion of the vena cava, weakening of the walls of blood vessels.
These drugs dilate blood vessels, enhance blood circulation in the capillaries, relieve swelling of tissues and establish metabolic processes in the walls of blood vessels. As a result, the veins do not stretch, gain elasticity. Angioprotectors are used in the treatment of lesions of the coronary vessels, vessels of the legs, and vascular lesions in patients with diabetes.
Description of dosage form
Solution for intravenous and intramuscular administration. Transparent, colorless or slightly colored liquid. Solution for intravenous and intramuscular administration of 30 mg/ml. Ml or 5 ml in ampoules. 10 ampoules of 1 ml are placed in cardboard boxes with a paper insert. 5 ampoules of 1 ml or 5 ml are placed in a blister strip packaging from a polyvinyl chloride film.
Judging by the formal classification, the group of angioprotective drugs is divided into drugs, which are available in the form of tablets for oral administration, as well as suppositories, creams, gels, ointments for local use.
To improve the effect during treatment, anti-inflammatory, antibacterial elements are added to the medication.
List of popular drugs divided into groups
Medicines that have an angioprotective effect are divided by origin into herbal preparations and synthesized, which are produced by means of chemical reactions.
The first include horse chestnut extracts, vitamin complexes, glucocorticoids. The second group includes synthetic substances that help improve microcirculation and block inflammatory reactions.
Angioprotectors, drug list:
- Venotonic drugs (troxevasinum).
- Regulatory drugs for small vessels.
- Vasodilators (Tivomax).
- Eliminating increased blood coagulability – anticoagulants.
- Suppressing the adhesion of blood cells and the formation of blood clots (clopidogrel).
- Metabolism enhancing drugs.
Release form – in the form of tablets and capsules.
Protects blood vessels and increases their tone. Tablets improve microcirculation in the capillaries, block inflammatory reactions.
Helps to eliminate the lack of vitamins C, P, strengthens the walls of blood vessels, reduces their permeability, normalizes the level of immunity.
Tones up vascular walls, eliminates puffiness. The extraction of horse chestnut normalizes the adrenal cortex to produce hormones, eliminates fragility of blood vessels and activates metabolic processes in the tissues of the body.
Increases capillary resistance, eliminates inflammatory reactions, normalizes blood flow. Often prescribed in the treatment of hemorrhoids, with venous insufficiency.
Restores vascular walls, eliminates inflammation, normalizes blood counts, improves the structure of red blood cells. It is used for hemorrhoids, varicose veins, trophic ulcers.
The drug is made on the basis of plant components, eliminates inflammation, swelling, restores vascular permeability.
For external use, the agents listed below are usually recommended.
It has a decongestant, anticoagulant, regenerative effect, prevents the formation of blood clots. It is often used in the treatment of hemorrhoids, since it well eliminates blood stasis, and also helps to reduce the manifestation of pain, itching.
Effectively combats the occurrence of edema. It is available in the form of a gel that is easily absorbed into the skin, so it gives quick results in eliminating edema and pain in the limbs. It removes inflammatory processes, promotes resorption of blood clots.
It is used for inflammatory reactions, dilation of veins, edema.
The list of drugs is quite large, but self-medication is extremely undesirable, since only a specialist can choose the best remedy in each individual case.
Angioprotectors can be prescribed by phlebologists, cardiologists, and angiosurgeons. Medications in tablets and injections are usually used 2 times a day.
Angioprotectors, which are taken orally, are available in tablet form. And also in the form of capsules and solutions for injection into a vein and muscle.
|internal medicines||external means|
|· Drug vazoket;||Heparin ointments;|
|Detralex medicine||External agent Procto-Glivenol;|
|Phlebotonic phlebodia 600;||Gel proctosan;|
|· Aescusan medication;||Lyoton gel;|
|Anticoagulant Aspirin;||Hepatrombin ointment;|
|Disaggregant Fraxiparin;||· Troxevasin gel;|
|· The drug Troxevasinum;||Cream Proctosedyl.|
Capsules and solutions for injection into a vein and muscle
Angioprotectors that are of natural plant origin are synthesized natural substances.
Herbal preparations of natural origin:
- The drug Diosmin;
- The medicine Eskuzan;
- Medication Esflazide;
- Aescin ointment.
Preparations based on herbal components are widely used for varicose veins.
These are means that reduce and reduce the permeability of the membranes of the capillaries, as well as veins of small diameter, for the ingress of fluid into them. This action helps to reduce swelling in the limbs and relieves leg fatigue.
The choice of drugs is based on the symptomatic manifestations of the disease and the results of diagnostic studies. Existing angioprotectors are divided into certain groups.
Microcirculation correctors – improve the rheological properties of blood, reduce viscosity, reduce the resistance of the inner surface of blood vessels with the movement of blood flow, eliminate microcirculatory disorders.
Pentoxifylline – prevents platelet adhesion with their subsequent formation in blood clots, dilates coronary vessels. It is indicated for use in coronary heart disease, trophic ulcers, peripheral circulation disorders, blood flow problems in the retina and choroid. Analogs – Pentilin, Trental, Flowerpot.
The drugs of the latest generation are prostaglandins Vazaprostan, Alprostan, Ilomedin. A distinctive feature of the new pharmacological product is the increased vasodilating effect several times. Less – the high cost of drugs.
Nitro group donors. The composition of the combined funds includes the amino acid arginine and its derivatives. Helps the enhanced formation of No-synthetase – a catalyst for the synthesis of nitric oxide in vascular cells. Reduce blood pressure, eliminate oxygen starvation of tissue structures, stabilize acid-base balance. Famous representatives of the series – Tivomax, Tivortin, are administered intravenously drip.
Metabolic agents – regulate intracellular metabolic processes. Restores the microcirculation of the bloodstream. Increase oxygen levels in tissues.
Aescusan. Contains chestnut extract and vitamin B1. Preserves the tone of the vascular walls, activates filtration, relieves swelling. It stimulates the production of hormones, which allows you to normalize the metabolism in the capillaries and tissues. The plant base is the key to good absorption in the digestive tract without side effects.
• methylethylpyridinol hydrochloride (emoxipine) – 30 g. • Sodium phosphate disubstituted 12-water (sodium hydrogen phosphate dodecahydrate) 7,0 g. • sodium sulfite (sodium sulfite) -1,0 g. • Water for injection – up to 1 liter.
Hypersensitivity, pregnancy. Hypersensitivity, pregnancy.
Short-term agitation, drowsiness, increased blood pressure, allergic reactions (skin rashes, etc.;), local reactions – pain, burning, itching, hyperemia, densification of paraorbital tissues (resolves independently). Excitation (short-term), drowsiness, increased blood pressure, rash, local reactions: pain, burning sensation, itching, redness, tightening of paraorbital tissues.
Tree of pharmacological groups
Angioprotectors are substances that are used to eliminate trophic disorders in the form of ulcers. Let us consider in more detail what kind of drugs these are and what other therapeutic effect they can have on the body. The mechanism of action of this drug group is aimed at:
- Suppress inflammatory mediators (serotonin, histamine, bradykinin).
- An angioprotective agent has the ability to reduce the activity of hyaluronic acid derivatives.
- Normalize the permeability of the vascular walls.
- It is reliably known that angioprotectors improve microcirculation by improving the composition of the blood: reducing its viscosity, reducing the adhesion of blood cells to the walls of blood vessels.
- Some drugs from the pharmacological group of angioprotectors can affect the blood coagulation system.
Angioprotective drugs have a fairly wide spectrum of action and are used in the treatment of a large number of vascular and vein diseases.
Angioprojectors are designed to improve the functioning of the heart and blood vessels. Patency of small vessels and capillaries allows oxygen and nutrients to penetrate into the tissues. Tissues are intensively renewed, stagnation does not occur, venous nodes, inflammations are eliminated, the vessel wall is strengthened. These drugs inhibit the formation of hyaluronidase and prostaglandins.
The mechanism of work of group drugs has not yet been studied. Different drugs of this series act differently and have positive and negative sides. For example, pentoxifylline dilates blood vessels, but also enhances blood viscosity. Main properties: Increased metabolic rate in tissues and good microcirculation;
Cardioxypine reduces the permeability of the vascular wall, the viscosity and coagulability of the blood, and the ability of red blood cells to adhere. Enhances the process of fibrinolysis. Improves microcirculation. Effectively inhibits free radical oxidation of lipids of biomembranes, increases the activity of antioxidant enzymes. It stabilizes cytochrome P-450, has an antitoxic effect.
In extreme situations, accompanied by increased lipid peroxidation and hypoxia, optimizes bioenergy processes. The drug protects the retina from the damaging effects of high-intensity light, promotes resorption of intraocular hemorrhages. Cardioxypine reduces signs of cerebral hemodysfunction.
Increases brain resistance to hypoxia and ischemia. In cases of cerebrovascular accident (ischemic and hemorrhagic), it contributes to the correction of autonomic dysfunctions, facilitates the restoration of integrative brain activity, and improves mnemonic functions. It has a hypolipidemic effect, reduces the synthesis of triglycerides.
The drug has a pronounced cardioprotective effect. Expands coronary vessels, reduces ischemic damage to the myocardium. With myocardial infarction, it limits the size of the focus of necrosis, accelerates reparative processes, and helps normalize myocardial metabolism. It has a beneficial effect on the clinical course of myocardial infarction, reducing the incidence of acute heart failure.
With intravenous administration at a dose of 10 mg/ml, a low half-elimination period was noted (T½ – 18 min, which indicates a high rate of elimination of the drug from the blood. The elimination constant is 0,041 min; total CI clearance is -214,8 ml/min, apparent volume V distribution each – 5,2 L. The drug quickly penetrates into organs and tissues, where it is deposited and metabolized.
Dosing and Administration
In neurology, neurosurgery and cardiology. Start with an intravenous drip (20-40 drops per minute) of the introduction of 20-30 ml of a 3% solution of emoxipin (600-900 mg) in 200 ml of a solution of sodium chloride isotonic or 5% glucose solution 1-3 times a day for 5-15 days, depending on the course of the disease, followed by an intramuscular injection of 2-10 ml of a 3% solution 2-3 times a day for 10-30 days.
Side effects of the components
Side effects of angioprotectors:
- The dizziness of the head can be so strong that it provokes nausea with vomiting;
- Body fatigue;
- General malaise;
- Discomfort in the stomach;
- Vomiting from the body;
- Severe diarrhea;
- A sharp decrease in blood pressure index, which provoked hypotension;
- Rap >
Side effects when used in newborns:
- Pathology of hyperthermia;
- A strong decrease in blood pressure – hypotension;
- Severe diarrhea;
- Heart palpitations – tachycardia;
- Slow heartbeat – bradycardia;
- The heart rhythm is broken – arrhythmia of the heart organ;
- Muscle cramps;
- Labored breathing;
- ICE syndrome develops.
In case of an overdose, it is necessary to rinse the stomach, and take sorbents. Also monitor the flow of fluid into the body to maintain water balance and prevent dehydration. And immediately contact your doctor.
When administered intravenously – a burning sensation along the vein, there may be an increase in blood pressure, agitation, or drowsiness. With a predisposition to allergic reactions in rare cases, itching and redness of the skin are observed.