Diastasis of urine what is it, norms, causes of deviations

Urine diastase is a natural enzyme produced by two glands in the human body. The first is the pancreas, and the second is the salivary gland. The analysis for this enzyme becomes relevant in conditions of painful manifestations in the abdomen, as well as suspicions of the development of pancreatitis.

The rate of the enzyme in the urine is closely related to the amount of the same in the blood. The optimal rate of diastase, or as it is also called alpha-amylase, varies from 16 to 128 units. It is also worth noting that the amount of enzymes may differ depending on the chosen laboratory and methods of analysis.

Why is the urine diastase enzyme necessary?

Primarily, this enzyme plays an important role in the process of breaking down carbohydrates into smaller pieces. His task is to translate the sugar content into the optimal combination – from 1 to 3 mg per 1 liter.

To accomplish this task, the amount of the enzyme must range from 16 to 64 units. If we compare the latter with the activity after eating and the flow of the digestive tract, then the amount of diastase is significantly reduced.

When should you get tested?

In this case, the answer can be unambiguous, since urine analysis is given exclusively on an empty stomach. Fried, spicy foods and especially sweet tea should be excluded from the late evening diet.

How much diastase is acceptable?

For a healthy person, the amount of diastase should not exceed 65 units per liter of analyzed fluid. But even the lower figure should not decrease by more than 16 units.

It should be noted that if the concentration of the enzyme in the urine is found within 8000 units, the likelihood of acute pancreatitis should definitely be excluded.

Inflammation of the pancreas is fraught with the destruction of the secretory cells of the organ. In this scenario, the amount of the enzyme, on the contrary, should be reduced by absorption into the blood, the connection with which was mentioned above.

Diagnostic principle

Before proceeding with the consideration of the diagnostic conditions for the content of this enzyme, it is worth reiterating the normal content of the enzyme for children and adults. This maximum value is 64 and 128, respectively. They should not be taken as categorical, since the content of diastase is unique for each person.

A completely different case, when, according to the results of the analysis, diastasis is completely absent. This can be distinguished by blockage of the pancreatic ducts and, therefore, % evidence of the presence of renal failure.

Analysis in laboratory conditions is performed taking into account the use of certain reagents, namely:

  • Toluene.
  • 0,85% saline.
  • Starch solution.
  • Phosphate buffer solution.

First of all, the specialist proceeds to warm up the physiological solution in the amount of 70 ml. The latter must be brought to a boil. In the second, additional test tube, pour 3 ml of cold saline solution, followed by mixing with starch in a ratio of three to one. The contents of this test tube are thoroughly mixed with a complete glass rod.

As a next step, the content of the additional tube is mixed with boiling saline. Actions can be duplicated at the discretion of the laboratory assistant, with decontamination of the previous stage with saline.

At the final stage, the resulting product must be allowed to cool, and then poured into a separate 100 ml glass flask, filling it to the first mark. After that, they start working with starch. It is diluted with saline until 90 ml of liquid is obtained.

10 ml of toluene and a similar amount of buffer solution are added to them. The presence of a phosphorus buffer in the total amount of the analyzed agent allows to extend its shelf life up to 90 days. If the analysis is carried out exclusively instantly, then it can be excluded.

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To complete the urine analysis for diastasis, you will also need to use an iodine solution.

Decryption of analyzes

Performed by a specialist as follows:

  • A test tube with no diastatic effect is determined.
  • Return to the previous tube out of the total 15.
  • Mixing the contents with an iodine solution in a ratio of 1 to 16.
  • Confirmation of digestion of 2 ml starch in a test tube.
  • Projecting the result per 1 ml of pure urine – 32 ml of starch.

Thus, the level of the enzyme “d” is at around 32 units, which is the norm for both an adult and a child.

Reasons for rejection

The reasons for the deviation of the level of diastase in the urine can be various diseases that have different symptoms and the complexity of the course.

These include:

  • Pancreatitis.
  • Diabetes.
  • Peritonitis.
  • Renal failure.
  • Injury to the abdomen.
  • Parotitis.
  • Pregnancy.
  • Regular intake of alcohol, up to the time of the test.

Why is an increased level of diastase dangerous?

The amylase level itself, regardless of its flow state, does not pose any health hazard, with the exception of those diseases, which is evidenced by the diagnostic results. If you ignore this fact, the above reasons for its appearance can progress to chronic – hazardous to health.

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Svetlana Borszavich

General practitioner, cardiologist, with active work in therapy, gastroenterology, cardiology, rheumatology, immunology with allergology.
Fluent in general clinical methods for the diagnosis and treatment of heart disease, as well as electrocardiography, echocardiography, monitoring of cholera on an ECG and daily monitoring of blood pressure.
The treatment complex developed by the author significantly helps with cerebrovascular injuries and metabolic disorders in the brain and vascular diseases: hypertension and complications caused by diabetes.
The author is a member of the European Society of Therapists, a regular participant in scientific conferences and congresses in the field of cardiology and general medicine. She has repeatedly participated in a research program at a private university in Japan in the field of reconstructive medicine.