What are angioprotectors list of drugs mechanism of action indications contraindications

The action of drugs in this group is aimed at:

  • Normalization of vascular wall permeability.
  • Elimination of inflammatory response factors.
  • Decreased production of hyaluronic acid.
  • Normalization of the structural composition of blood.
  • Decrease in coefficient of viscosity of blood.
  • Reducing the risk of thrombosis.

Angioprotectors are drugs that have a wide range of effects on vascular diseases. The group includes many drugs for internal and external use.

The angioprotective effect allows you to normalize blood flow and improve the functionality of the blood flow system of the whole body, especially improve blood flow in the periphery.

Therapeutic properties of angioprotectors:

  • Suppress the synthesis of hyaluronidase;
  • It has the functions of antagonists of prostaglandin molecules;
  • Reduce platelet molecule aggregation;
  • Stimulate the production of mucopolysaccharide molecules in capillary membranes;
  • Improves the permeability of the membranes of arteries;
  • Reduce the adhesion of platelet molecules in blood plasma.

Side effects of angioprotectors:

  • Headache;
  • The dizziness of the head can be so strong that it provokes nausea with vomiting;
  • Body fatigue;
  • General malaise;
  • Discomfort in the stomach;
  • Vomiting from the body;
  • Severe diarrhea;
  • A sharp decrease in blood pressure index, which provoked hypotension;
  • Rapid heartbeat – tachycardia;
  • Violation of the rhythm in the work of the heart muscle – arrhythmia;
  • Phlebitis at the injection site;
  • Increased perspiration by the body;
  • Pathology of hyperthermia;
  • Allergy to components;
  • The development of bone hyperostosis – when taken for a long time.

Side effects when used in newborns:

  • Pathology of hyperthermia;
  • A strong decrease in blood pressure – hypotension;
  • Severe diarrhea;
  • Heart palpitations – tachycardia;
  • Slow heartbeat – bradycardia;
  • The heart rhythm is broken – arrhythmia of the heart organ;
  • Muscle cramps;
  • Labored breathing;
  • ICE syndrome develops.

In case of an overdose, it is necessary to rinse the stomach, and take sorbents. Also monitor the flow of fluid into the body to maintain water balance and prevent dehydration. And immediately contact your doctor.

Angioprotectors that improve blood circulation through the smallest vessels are called microcirculatory normalizers. Their action is aimed at reducing blood viscosity (improving rheology) and reducing the resistance of the inner layer of blood vessels to its advancement. This improves blood circulation in small vessels, which account for the main load in foci with chronic microcirculatory disorders.

The general classification, types and list of drugs are given in the table.

GenerationfirstSecond
Active ingredient and preparationsPentoxifyllinePillsInjectionsProstaglandin (alprostadil) only in solution for injections
Pentiline
TrentalVazaprostan, Alprostan
FlowerpotIlomedin

Principle of operation

The mechanism of action of drugs of the group of angioprotectors is not fully understood. It is clear that due to the activation of circulation in small vessels, the blood composition improves. This in turn leads to the elimination of edema, normalizes metabolism and increases vascular tone.

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This group of drugs contains drugs that have different effects:

  • The synthesis of hyaluronidase (enzyme) is slowed down or the activity of its secondary products is blocked.
  • Eliminate stagnant processes.
  • Expand blood vessels, thereby lowering blood pressure.
  • Weaken the effect of prostaglandins (these are bioactive substances).
  • Eliminate platelet adhesion.
  • They contribute to the formation of mucopolysaccharides, which leads to an increase in the permeability of the capillary wall.
  • Eliminate the adhesion of blood cells to the walls of the capillaries.
  • Eliminate the signs of endothelial dysfunction – permanent and progressive damage to the inner layer of vascular cells (endothelium).
  • Reduce oxidative stress – the process of cell damage due to oxidation.
  • Remove inflammatory processes.

Classification

In medicine, the use of angioprotectors and correctors of blood circulation in capillaries is practiced, there are about 150 items. All these drugs are included in one subgroup of drugs for the treatment of cardiovascular diseases.

Most commonly used classification, which divides them into two categories.

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Monopreparations

This category includes drugs characterized by the content of one active component (for example, Troxerutin):

  • Natural herbal preparations.
  • Semi-synthetic drugs.
  • Synthetic medicines.

The composition includes numerous components:

  • Components that are based on the content of one or several identical active substances that are interchangeable by the effect on the body. Diosmin, hesperidin – active components. Preparations of the micronized purified fraction of flavonoids are considered the most effective for various degrees of vascular disease.
  • Substances that include flavonoids from grape leaves. Production using an aqueous extract enables the drug to be well absorbed in the gastrointestinal tract.
  • Proanthocyanidins or condensed tannins are powerful antioxidants that remove harmful oxygen free radicals from cells and contain grape seed extract.
  • The general group of triterpenic acids.
  • Needle hood.
  • Ginkgo hood.

Combined drugs include Detralex, Venodiol, Antistax, Indovazin and others.

Differing in the mechanism of action, these drugs are used at various stages of venous diseases. The most studied angioprotectors are medicines from the MFF group. They show a high clinical effect during the treatment of all types and stages of pathological processes of veins.

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Angioprotective drugs are divided in several directions:

  • According to the form of origin (synthetic and natural plant);
  • By its composition of components (mono-preparations is troxerutin and several components in a combined agent are Detralex, the drug Indovazin).
Generation numbervasoprotectors generation number 1generation number 2
drugsPentoxifylline angioprotectortableted fundsinjections· Prostaglandin (alprostadil) only injection;
Pentilin angioprotective drugpillsinjections
angioprotective drug Trentaltableted fundsinjections· Vazaprostan – tablets, injections;
· Alprostan – tablets, injections.
vasoprotector Wasonitetableted funds· Ilomedin – tablets and injections;

Classification of angioprotectors by pharmacological species

In medicine, the use of angioprotectors and correctors of blood circulation in capillaries is practiced, there are about 150 items. All these drugs are included in one subgroup of drugs for the treatment of cardiovascular diseases.

Monopreparations

List of effective drugs

Medicines that have an angioprotective effect are divided by origin into herbal preparations and synthesized, which are produced by means of chemical reactions.

The first include horse chestnut extracts, vitamin complexes, glucocorticoids. The second group includes synthetic substances that help improve microcirculation and block inflammatory reactions.

Angioprotectors, drug list:

  • Venotonic drugs (troxevasinum).
  • Regulatory drugs for small vessels.
  • Vasodilators (Tivomax).
  • Eliminating increased blood coagulability – anticoagulants.
  • Suppressing the adhesion of blood cells and the formation of blood clots (clopidogrel).
  • Metabolism enhancing drugs.

Release form – in the form of tablets and capsules.

Detralex

Protects blood vessels and increases their tone. Tablets improve microcirculation in the capillaries, block inflammatory reactions.

Ascorutin

Helps to eliminate the lack of vitamins C, P, strengthens the walls of blood vessels, reduces their permeability, normalizes the level of immunity.

Aescusan

Tones up vascular walls, eliminates puffiness. The extraction of horse chestnut normalizes the adrenal cortex to produce hormones, eliminates fragility of blood vessels and activates metabolic processes in the tissues of the body.

Phlebodia

Increases capillary resistance, eliminates inflammatory reactions, normalizes blood flow. Often prescribed in the treatment of hemorrhoids, with venous insufficiency.

Venoruton

Restores vascular walls, eliminates inflammation, normalizes blood counts, improves the structure of red blood cells. It is used for hemorrhoids, varicose veins, trophic ulcers.

Troxevasin

The drug is made on the basis of plant components, eliminates inflammation, swelling, restores vascular permeability.

For external use, the agents listed below are usually recommended.

Hepatrombin

It has a decongestant, anticoagulant, regenerative effect, prevents the formation of blood clots. It is often used in the treatment of hemorrhoids, since it well eliminates blood stasis, and also helps to reduce the manifestation of pain, itching.

Lioton

Effectively combats the occurrence of edema. It is available in the form of a gel that is easily absorbed into the skin, so it gives quick results in eliminating edema and pain in the limbs. It removes inflammatory processes, promotes resorption of blood clots.

Essaven Gel

It is used for inflammatory reactions, dilation of veins, edema.

The list of drugs is quite large, but self-medication is extremely undesirable, since only a specialist can choose the best remedy in each individual case.

Angioprotectors can be prescribed by phlebologists, cardiologists, and angiosurgeons. Medications in tablets and injections are usually used 2 times a day.

Release form – in the form of tablets and capsules.

Essaven Gel

contraindications

There is a list of contraindications even to the latest generation of drugs:

  • Individual intolerance of components.
  • Diseases of the stomach and intestines.
  • Age to 18 years.
  • Separate funds are not recommended for admission at 1, 2 trimesters of pregnancy, during lactation.

Means for external use are not recommended for:

  • The presence of wounds, burns.
  • Infectious skin diseases.
  • Allergic processes on the effects of drugs in this group.
  • Trophic ulcers during therapy.

Before starting treatment, it is necessary to study the instructions for using the selected product for the purpose and contraindications for use.

Angioprotectors are a pharmacological group of medications that are intended for the treatment of vascular pathologies and diseases of the heart organ.

These drugs are used:

  • To improve the functionality of the choroid;
  • To improve blood microcirculation;
  • To increase the rheological effects of blood;
  • To normalize metabolism in the cells of organ tissues.

Contraindications to the appointment of drugs of the pharmacological group, angioprotectors can be:

  • Intolerance to the body of certain ingredients in the composition of the preparations;
  • With inflammation in the digestive system;
  • In case of disruption of the stomach and intestines;
  • Children who are not yet 16 years old;
  • In the period of intrauterine gestation. The use of drugs during pregnancy is prohibited especially in the first or second trimester of fetal development;
  • Breastfeeding a baby.

External preparations with angioprotective properties are not prescribed:

  • If there are abrasions and wounds on the skin;
  • With infections on the soft fibers of the skin;
  • Allergy to components;
  • With non-healing trophic ulcers that are not amenable to medical treatment.

The use of angioprotective drugs is allowed only with the appointment of a treating doctor who will prescribe the scheme of angiotropic therapy, and also calculate the correct dosage of drugs.

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Svetlana Borszavich

General practitioner, cardiologist, with active work in therapy, gastroenterology, cardiology, rheumatology, immunology with allergology.
Fluent in general clinical methods for the diagnosis and treatment of heart disease, as well as electrocardiography, echocardiography, monitoring of cholera on an ECG and daily monitoring of blood pressure.
The treatment complex developed by the author significantly helps with cerebrovascular injuries and metabolic disorders in the brain and vascular diseases: hypertension and complications caused by diabetes.
The author is a member of the European Society of Therapists, a regular participant in scientific conferences and congresses in the field of cardiology and general medicine. She has repeatedly participated in a research program at a private university in Japan in the field of reconstructive medicine.

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