Plasma Protein Fractions

About 8% of the plasma composition is in proteins. Proteins in the blood, in turn, consist of a fraction of albumin (5%), a fraction of globulins (4%), fibrinogen (0,4%). Thus, 1 liter of plasma contains 900 grams of water, 70 grams of protein and 20 grams of molecular compounds.

The most common protein is albumin in the blood. It is formed in the liver and occupies 50% of the protein group. The main functions of albumin are transport (transfer of trace elements and drugs), participation in metabolism, protein synthesis, amino acid reservation. The presence of albumin in the blood reflects the condition of the liver – a lower albumin indicator indicates the presence of the disease. Low albumin in children, for example, increases the chance of jaundice.

Globulins are large molecular components of a protein. They are produced by the liver and organs of the immune system. Globulins can be of three types: beta, gamma, alpha globulins. All of them provide transport and communication functions. Gamma globulins are also called antibodies, they are responsible for the reaction of the immune system. With a decrease in immunoglobulins in the body, a significant deterioration in the immune system is observed: there are constant bacterial and viral infections.

Protein fibrinogen is formed in the liver and, becoming fibrin, it forms a clot at the sites of vascular damage. Thus, the liquid component of the blood is involved in the process of coagulation.

Among non-protein compounds are present:

  • Organic nitrogen-containing compounds (urea nitrogen, bilirubin, uric acid, creatine, etc.). An increase in nitrogen in the body is called azotomy. It occurs when there is a violation of the excretion of metabolic products with urine or with an excessive intake of nitrogenous substances due to the active breakdown of proteins (starvation, diabetes, burns, infections).
  • Organic nitrogen-free compounds (lipids, glucose, blood cholesterol, lactic acid). To maintain good health, you need to keep track of a number of these vital indicators.
  • Inorganic elements (calcium, sodium salt, magnesium, etc.). Minerals are also essential components of the system.

Plasma ions (sodium and chlorine) maintain an alkaline blood level (ph), which ensures the normal state of the cell. They also play the role of supporting osmotic pressure. Calcium ions are involved in muscle contraction reactions and affect the sensitivity of nerve cells.

During the life of the body, metabolic products, biologically active elements, hormones, nutrients and vitamins enter the bloodstream. In this case, the composition of the blood does not specifically change. Regulatory mechanisms provide one of the most important properties of blood plasma – the constancy of its composition.

Indications for the purpose of the analysis – protein fractions:

  1. Acute and chronic inflammatory diseases (infections, diffuse connective tissue diseases, collagenoses, autoimmune diseases).
  2. Suspicion of myeloma and other monoclonal gammopathies.
  3. Malnutrition and malabsorption syndrome.
  4. Screening examinations.

Preparation for the study:
fasting blood.

Material for research:
blood serum.

Plasma function

The most important function of blood plasma is hemostasis (ensuring the operation of the system in which the fluid is able to stop during various types of bleeding and remove the subsequent blood clot involved in coagulation). The task of plasma in the blood also comes down to maintaining stable pressure in the body.

Human diseases that affect the composition and characteristics of plasma in the blood are extremely dangerous.

Allocate a list of diseases:

  • Sepsis of the blood – occurs when the infection enters directly into the circulatory system.
  • Hemophilia in children and adults is a genetic protein deficiency responsible for coagulation.
  • Hypercoagulant condition – coagulation too fast. In this case, the viscosity of the blood increases and patients are prescribed drugs to dilute it.
  • Deep vein thrombosis – the formation of blood clots in deep veins.
  • DIC-syndrome – the simultaneous occurrence of blood clots and bleeding.

All diseases are associated with features of the functioning of the circulatory system. The impact on individual components in the structure of blood plasma can reverse the normal vitality of the body.

Plasma is a liquid component of blood with a complex composition. She herself performs a number of functions without which the vital activity of the human body would be impossible.

For medical purposes, plasma in the blood is often more effective than a vaccine, since its immunoglobulins reactively destroy microorganisms.

What does deviation from the norm mean?

albumin 52 – 65%? 1-globulins 2,5 – 5%? 2-globulins 6 – 11%? -globulins 8 – 14%? – globulins 15 – 22%

1. Eating Disorders. 2. Malabsorption syndrome. 3. Diseases of the liver and kidneys. 4. Tumors. 5. Collagenoses. 6. Burns. 7. hyperhydration. 8. Bleeding. 9. Analbuminemia. 10. Pregnancy. 11. Severe inflammatory diseases.

1. Hereditary deficiency of alpha-1-antitrypsin. 2. Deficiency of alpha-1-lipoprotein.

1. Decrease in alpha-2-macroglobulin (pancreatitis, burns, injuries). 2. Decrease in haptoglobin (hemolysis of various etiologies, pacreatitis, sarcoidosis).

1. Hypobetalipoproteinemia. 2. IgA deficiency.

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? -Globulin fraction

1. Immunodeficiency conditions. 2. Taking glucocorticoids. 3. Plasmapheresis 4. Pregnancy.

Reviews

Currently, I am a resident of the Crimea, I learned about unique methods of treatment in the clinic, I came here with problematic .

Currently, I am a resident of the Crimea, I learned about unique methods of treatment at the Clinic and came here with problematic issues of my health. I went through diagnostics, laboratory tests and then a course of treatment. I feel much better, I’m leaving with good health potential. Thanks to Valentina Dmitrievna, Valery Ivanovich, nurse Natalia Lavrinenko for my sensitive attitude to me

thanks to the oculist Olga Valentinovna for the consultation – a very good doctor – I will advise everyone!

I came to the FTC with joint pain, expressed by varicose veins, complaints about the work of the stomach. After .

I came to the FTC with joint pain, expressed by varicose veins, complaints about the work of the stomach.
After the sessions, acute pain in the knee joint was gone. Swelling of the lower extremities has passed, veins have decreased in size, the work of the stomach has stabilized, pressure has returned to normal.
Never in my life during all the time of going to hospitals for such a short period have I been diagnosed, moreover, all studies are painless and not burdensome for the body.

It so happened that I was already falling. I had problems with the thyroid gland, my bones hurt a lot, .

It so happened that I was already falling. I had problems with the thyroid gland, my bones were very sore, I was very swollen. After undergoing treatment in the clinic, I can say they put me on my feet. I have already recommended to all my friends and acquaintances to solve health problems in this clinic, especially taking into account the cost of medicines that are now prescribed in clinics.

I have been sick for a long time. The joints are very sore, the thyroid gland is worried. The joints hurt and under load and in a condition .

I have been sick for a long time. The joints are very sore, the thyroid gland is worried. The joints hurt both during exercise and at rest. I periodically undergo medical treatment from the age of 98. She was treated in Moscow in the Arthrocentre, underwent spa treatment in Pyatigorsk. However, my condition only worsened, it was clear that there was no sense in such treatment.

I found out about Kulikovich’s clinic by chance from a fellow traveler on a train. Most of all in her story, I liked that here the body as a whole is treated, and not a specific bone. Those. the reason why everything works out. Three months later, I was ripe for arrival in Dnepropetrovsk. Here I quickly underwent a comprehensive diagnosis.

I worked as a teacher of a medical academy for 35 years, I have been suffering from rheumatoid arthritis for more than 10 years .

I worked as a teacher of a medical academy for 35 years; I have been suffering from rheumatoid arthritis for more than 10 years. I tried various medications, both steroidal and anti-inflammatory. Now I have come to the conclusion that treatment in the clinic of Dr. Kulikovich is more effective and sparing. This treatment allows you to not take drugs with strong side effects and, at the same time, the therapeutic effect is long-lasting and helps to prevent joint inflammation.

I got to the clinic with pancreatic problems. Having been diagnosed and treated, I was pleased and .

I got to the clinic with pancreatic problems. Having been diagnosed and treated, I was satisfied with the attitude of the staff and the end result. After undergoing a course of treatment sessions, painful sensations are not observed, feeling good. The only unpleasant memories associated with acupuncture, for me it was a little painful. The rest of the procedures were comfortable. I believe that in this clinic the optimal price-quality ratio.

I want to express my heartfelt gratitude to Yuri Nikolaevich Kulikovich for creating such a clinic, for the good .

I want to express my heartfelt gratitude to Yuri Nikolaevich Kulikovich for creating such a clinic, for the kind and sensitive attitude of the staff, starting with the administrators: Tatyana Anatolyevna and Irina Alexandrovna, who will always patiently tell about the time of the research, the entire first floor of the staff for diagnostic tests and the medical department of the second floor.
I want to wish all employees health, success, happiness.

We came from far away, and were very moved by the care and attention with which we were surrounded at the Clinic. Many thanks,…

We came from far away, and were very moved by the care and attention with which we were surrounded at the Clinic. Thank you very much, Tanya from the reception desk, which helped us get a job. My daughter went to classes with a speech therapist Svetlana Nikolaevna, a very competent and very sensitive doctor, with pleasure. Which, with its exactingness, made her daughter seriously work.

I am very grateful to you for everything, Svetlana Nikolaevna. Thank you for your sensitivity, attention and professionalism to the neurologist Valery Ivanovich. We are very pleased with the treatment results. We wish you happiness Oksanke (room # 1). Thank you very much for her attention, love and care for my child. More doctors and good people like yours in the Clinic.

Complaints about the musculoskeletal system forced me to go to the clinic, my knees and hips hurt .

Complaints about the musculoskeletal system made me go to the clinic, my knee and hip joints and bones on my legs hurt. After the examination, it turned out that I had problems with many internal organs, some of which I did not even guess. So the lower back bothered me before, I thought it was radiculitis, but the kidneys turned out to be.

After treatment, the clinic has no complaints. The mobility in the joints improved, they stopped hurting. The tests normalized, urine, blood. I really liked it here, especially attentive and conscientious attitude towards me. Earlier after treatment in other places, it was not clear to me whether the treatment helped or not, in this clinic I feel the result of treatment.

I want to express my gratitude to the whole team of the Kulikovich Clinic, for the assistance I received in the treatment, in .

I want to express my gratitude to the whole team of the Kulikovich Clinic for the assistance I received in the treatment, especially to the very attentive medical nurses. I don’t know how much else I would have to hurt if it weren’t for your Clinic. Thanks so much for everything!

The first thing that impressed me was fashion, but it was a shell. Most importantly, during the treatment I .

The first thing that impressed me was fashion, but it was a shell. Most importantly, during the treatment I met the warmth, friendliness and attention of the staff. Special thanks to the attending physician Yuri Vladimirovich and all his colleagues. Analyzes will show what the results of the treatment are, but the general condition, emotional uplift and surge of energy are the result of both medical procedures and a pleasant time of transmission and interesting communication.

I am very grateful to the people who work here for the kindness and warmth that they radiate, for the attitude that .

I am very grateful to the people who work here for the kindness and warmth that they radiate, for the attitude that is so expensive in our lives, and right now. Many thanks to the doctors and nurses, to all the staff. Here you feel calm and confidence comes that everything will be fine with you!

I sincerely thank all the clinic staff for the warm professional attitude to the patient, for .

I express my gratitude to the entire staff of the clinic for the warm professional attitude to the patient, for the complete and, most important for the pensioner, free treatment that gives a positive result (for osteoporosis). Thank you so much for the advice and important recommendations. Health to all of you, creative successes in hard medical work, all the best!

I, a medical worker with 17 years of experience. I work in the Central Hospital of Verkhnedneprovsk. Until today, in private .

I, a medical worker with 17 years of experience. I work in the Central Hospital of Verkhnedneprovsk. Until today I haven’t been in private clinics, and I really regret it, after that I visited your clinic. For the first time I came across such an attentive and professional attitude to my business. And the situation in the Clinic itself gives an excellent mood and the belief that all diseases are treatable. Many thanks to Kulikovich Yu.N. for creating such a clinic with an excellent team.

In biochemical analysis, fractions of blood proteins reflect the state of protein metabolism.

Such a diagnosis is important for many diseases, so you should understand what protein fractions are and what values ​​are considered normal.

Human blood plasma includes about a hundred different protein components (fractions). Most of them (up to 90%) are albumin, immunoglobulins, lipoproteins, fibrinogen.

The remainder includes other protein components that are present in plasma in small quantities.

Serum contains approximately 7% of all proteins, and their concentration reaches 60 – 80 g / l. The value of fractions in the blood is huge.

Proteins provide the perfect acid-base balance of the blood, are responsible for the transport of substances, and control the viscosity of the blood. Proteins play a critical role in the circulation of blood vessels.

Mostly protein fractions of the blood are produced by the liver (fibrinogen, albumin, part of globulins). The remaining globulins (immunoglobulins) are synthesized by bone marrow and lymph cells.

Donation Application

In what situations and for what donor blood plasma is needed? Most often, not all blood is transfused, but only its components and plasma fluid. When taking blood, using special means they separate the liquid and the shaped elements, the latter, as a rule, are returned to the patient. With this type of donation, the frequency of donation increases to two times a month, but no more than 12 times a year.

Donor plasma transfusion

Blood serum is also made from blood plasma: fibrinogen is removed from the composition. At the same time, serum from plasma remains saturated with all antibodies that will resist microbes.

Albumin and Globulin Fractions

Albumins are simple water-soluble proteins. The most famous type of albumin is serum albumin. The fraction is produced by the liver and accounts for about 55% of all proteins contained in blood plasma.

The normal level of serum albumin in adults is in the range of 35-50 g / l. For children under the age of three, normal values ​​range from 25 to 55 g / l.

Albumin is produced by the liver and depends on the intake of amino acids. The main functions of the protein are the maintenance of plasma oncotic pressure and the control of bcc.

A fraction controls the content of free substances not related to protein fractions. This function of albumin allows it to be included in the detoxification process of the body.

Globulins are protein fractions of blood serum that have a higher molecular weight and less solubility in water, unlike albumin. Fractions are produced by the liver and immune system.

Alpha-1-globulins (prothrombin, transcortin, etc.) are responsible for the transport of cholesterol, cortisol, progesterone and other substances.

In addition, the fractions take part in the process of blood coagulation (second phase). The normal content of alpha1-globulins in the blood serum is from 3,5 to 6,5% (from 1 to 3 g / l).

At the same time, in children, the concentration of blood plasma protein fractions is slightly different: up to 6 months, the values ​​from 3,2 to 11,7% are considered the norm, with age, the upper limit drops and by age 7 reaches the norm in adults.

Alpha-2-globulins (antithrombin, vitamin D, binding protein, etc.) transport the ions of copper, retinol, calciferol.

The normal value of protein fractions of blood plasma in adults is in the range of 9-15% (from 6 to 10 g / l). In children under 18 years of age, a concentration of 10,6 to 13% is considered the norm.

Beta globulins are involved in the first phase of the blood clotting process. In adults, the accepted norm for the concentration of fractions in plasma is from 8 to 18% (from 7 to 11 g / l). For children, a decrease in the level of protein in the blood to 4,8 – 7,9% is characteristic.

Gamma globulins (IgA, IgG, IgM, IgD, IgE) are antibodies and B-lymphocyte receptors that provide humoral immunity.

The normal value for adults is the concentration of gamma globulins in the blood from 15 to 25% (from 8 to 16 g / l). In children, a decrease in the level of protein fractions to 3,5% (under the age of six months) and up to 9,8% (under the age of 18 years) is acceptable.

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Tatyana Jakowenko

Editor-in-chief of the Detonic online magazine, cardiologist Yakovenko-Plahotnaya Tatyana. Author of more than 950 scientific articles, including in foreign medical journals. He has been working as a cardiologist in a clinical hospital for over 12 years. He owns modern methods of diagnosis and treatment of cardiovascular diseases and implements them in his professional activities. For example, it uses methods of resuscitation of the heart, decoding of ECG, functional tests, cyclic ergometry and knows echocardiography very well.

For 10 years, she has been an active participant in numerous medical symposia and workshops for doctors - families, therapists and cardiologists. He has many publications on a healthy lifestyle, diagnosis and treatment of heart and vascular diseases.

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