Overview of the drug Perindopril arginine and its features

Perindopril Erbumin is the earliest type of medicine. More recently, only this type of drug was prescribed to patients. “Perindopril” based on erbumin salt was tested on 50 thousand patients and showed simply excellent results. However, this medicine has one rather significant drawback – not a very long shelf life.

Thus, from the very beginning, the exclusively erbumine “Perindopril” existed on the market. Prestarium A appeared in pharmacies in the Russian Federation and Ukraine only in 2000. Instead of erbumin salt, arginine salt was used in it. The pharmacological effect on the patient’s body, this substance has exactly the same. But at the same time it is devoid of the main disadvantage of erbumin.

Today, doctors are officially allowed to prescribe patients a medicine based on both arginine and erbumin. Indications for the use of these funds are exactly the same. At the cost of these drugs are slightly different. Erbumin-based drugs cost about 200-300 rubles per 30 tablets. 4 mg each, based on arginine – 300-400 rubles (depending on the manufacturer).

Prestance, Dalnev, Arginin Kombi, etc. medicines can be purchased, as already mentioned, in a pharmacy is possible only with a prescription prescribed by a doctor. Since the main active ingredient of all these drugs is perindopril, the instructions for use are similar. However, differences in the use of such funds, of course, exist. The table below provides instructions for each of the drugs described above.

Reception at a time

The number of receptions per day (times)

30 days after the start of administration, you can increase the dose to 10 mg

After a month, you can increase the dose to 8 mg

Prestarium Arginine Combi and Ko-Perineva

After a month, the dosage is increased to 4 mg

Perindopril amlodipine (Prestans and Dalnev)

The dose depends on the therapeutic need. Depending on this, tablets of a certain weight are prescribed

The above dosages are approximate. Treatment with drugs of the perindopril group can be prescribed only by a doctor. Depending on the state of health of the patient, the individual characteristics of his body, etc., the dosage of such drugs can vary significantly. Therefore, self-medication using drugs based on perindopril is in no case impossible. This can lead to more than sad consequences.

Tools based on the substance perindopril, the instructions for use of which are pretty simple, are, unfortunately, not suitable for all patients with high blood pressure or heart failure. Contraindications such drugs have the following:

allergy to the main active substance or auxiliary;

pregnancy and lactation.

For Arginine Combi, the main active substance of which is perindopril indapamide, among other things, there is such a contraindication as the presence of Quincke’s edema in the patient. Also, this drug should not be taken:

with renal failure;

violations of the liver;

hypokalemia and some other diseases.

The analogue of Perindopril, the medicine of Co-Pyrenev, has approximately the same contraindications. This drug, among other things, is not yet prescribed for children under 18 years of age. Older people should use it with caution.

Prestans (perindopril plus amlodipine) should not be taken by people:

That’s about the same effect and different drugs made on the basis of a substance called “perindopril” differ. The price for them, as you can see, is quite high. Yes, and you can’t buy such drugs in pharmacies without a prescription. Meanwhile, there are much cheaper analogues of them, and besides, they are sold quite freely. One such remedy is Lisinopril.

Like Perindopril tablets, this medicine is used to lower blood pressure. The main active ingredient in the composition of the drug is lisinopril dihydrate. This product is available, like Perindopril, in tablets. The cost of this drug is only 17 rubles per 30 pcs. 5 mg each.

“Enalapril” medicine lowers blood pressure, according to many patients, it’s very good. It acts, according to most patients, no worse than many expensive imported drugs of the same group. At the same time, Enalapril is much cheaper. But according to many patients, this medicine has one rather serious drawback.

FAS Russia, at the request of Teva, prepared clarifications on the interchangeability of drugs with INN perindopril and perindopril arginine, the department’s website said in a statement.

The document of the Federal Antimonopoly Service says that drugs with INN perindopril and perindopril arginine, which contain one active substance perindopril and the same route of administration (oral), are interchangeable and can be used on the same group of patients with equivalent indications and contraindications for use with achievement of an equivalent therapeutic effect.

According to the information received by the Federal Antimonopoly Service from FSBI “NTsESMP” of the Ministry of Health of the Russian Federation, perindopril and arginine recommended by the World Health Organization, perindopril recommended by the World Health Organization, should be indicated in the instructions for the use of drugs with INN perindopril and perindopril. Also, FSBI “NTsESMP” recommends that the instructions for medical use of all drugs with INN perindopril and perindopril arginine, registered in Russia, be brought into line with current information on the experience of clinical trials of drugs containing perindopril as the active substance. If changes to the instructions are not made, the agency will take measures in accordance with its competencies.

For most patients, a single cure for hypertension is not enough to lower the pressure to normal. If the pressure is 160/100 mm RT. Art. and above, then usually immediately prescribed two drugs for simultaneous administration. In severe cases, combinations of 3-4 antihypertensive drugs can be taken.

Perindopril is most often prescribed with indapamide or amlodipine. The effectiveness of such combinations has been confirmed by the results of large studies, which are described below. Perindopril-based combination drugs are effective and safe for patients with type 2 diabetes, as well as for other categories of patients.

If the patient has severe hypertension and a high cardiovascular risk, then he may be prescribed perindopril, indapamide and amlodipine at the same time. The effectiveness and good tolerance of such a triple combination has been proved by the results of studies conducted in English-speaking countries and in Russia. And if the simultaneous intake of 3-4 drugs for pressure does not help, then the method of sympathetic denervation of the renal arteries is used.

See, for example, the article “Results of a prospective open-label study evaluating the antihypertensive efficacy and tolerability of Noliprel Bi-Forte in patients with uncontrolled arterial hypertension and type 2 diabetes mellitus (PRACTICE study).” Authors – Sirenko Yu.N., Mankovsky B.N., Radchenko A.D., Kushnir S.N., Journal of Arterial Hypertension No. 4/2012.

Noliprel is a combination tablet containing perindopril and indapamide. If Noliprel at the maximum dose did not help enough, then amlodipine was added to it. The study lasted 3 months. The combination of three drugs for hypertension made it possible to keep the pressure below 140/90 mm Hg. Art. in 74,8% of patients.

The combination of drugs perindopril amlodipine is widely used in the West and in Russian-speaking countries to treat hypertension and reduce the risk of cardiovascular complications. It is theoretically grounded and in practice has proved its effectiveness. A popular medicine that contains perindopril and amlodipine is Prestanz. He also has an analogue of Dalnev, more affordable.

After Prestans entered the Russian market, the Russian Medical Society for Arterial Hypertension (RIOAG) initiated the PRORIV program – “Prestance in the treatment of uncontrolled arterial hypertension is a real chance to improve blood pressure control”. This is a large study in which 4115 patients took part.

Combined tablets containing perindopril and amlodipine, greatly reduce blood pressure and are well tolerated. If amlodipine causes swelling of the legs, then it is replaced by lercanidipine.

contraindications

This substance is an ACE inhibitor and has a vasodilating property. Its main function is the suppression of the angiotensin-converting enzyme, as a result of which the blood pressure normalizes and the work of the myocardium stabilizes.

  • cardiac ischemia;
  • arterial hypertension;
  • chronic heart failure.

Also, drugs with this active substance are indicated for stroke survivors to reduce the possibility of a repeat, with chronic high blood pressure to normalize it.

Be careful! Do not use preparations containing perindopril arginine to quickly reduce pressure and relieve hypertensive crisis.

The drug is available in the form of tablets, taken 1 time per day, 1 or ½ tablet (depending on the doctor’s prescription). When appointing, the general condition of the patient is taken into account, as well as the quality of the kidneys (the drug increases renal blood flow, giving a strong load on this organ). When prescribing perindopril arginine, the instructions for use are very important – do not prescribe the dosage yourself!

It is advisable to take pills in the morning, before meals, with plenty of water.

Do not take with food, this reduces the effectiveness of the action!

  • pregnancy;
  • lactation period;
  • contraindicated for use in children;
  • individual intolerance to ACE inhibitors.

In cases of overdose, there is a sharp strong decrease in blood pressure, cough, palpitations, vomiting, dizziness. With these symptoms, it is necessary to wash the stomach, take activated charcoal, lay the victim on a flat surface, slightly raising his legs, call an ambulance.

pharmachologic effectPerindopril is a member of the ACE inhibitor group. It is a prodrug from which the active metabolite perindoprilat is formed in the body. Under the influence of the drug, the conversion of angiotensin-I to angiotensin-II, which is a powerful vasoconstrictor, is slowed down. Vasodilating effect – due to the fact that the concentration of angiotensin-II in the blood plasma decreases. Increased cardiac output and exercise tolerance. Blood pressure drops within an hour after taking the medicine. The effect reaches a maximum by 4-8 hours and lasts for a day.
PharmacokineticsIn the process of metabolism, it transforms with the formation of an active metabolite – perindoprilat (about 20%) and 5 inactive compounds. The maximum concentration of perindoprilat in blood plasma is reached between 3 and 5 hours after taking the pill. The drug is excreted by the kidneys. If you take a pill with food, then its effect will slow down. In elderly patients, as well as in renal and heart failure, excretion of perindoprilat slows down, but still it does not accumulate in the body.
Indications for useThe main indications are arterial hypertension, stable coronary heart disease, chronic heart failure. Also, the prevention of re-stroke – perindopril is the only ACE inhibitor that has such an indication for use. As a rule, for patients who have suffered a stroke or transient ischemic attack, this medicine is prescribed together with the diuretic drug indapamide. Perindopril is often prescribed for hypertension in patients with type 1 and type 2 diabetes.

Pressure Pills: Questions and Answers

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  • High blood pressure, hypertensive crisis – features of treatment in young, middle and old age

Read detailed articles on the treatment of diseases:

  • Coronary heart disease
  • Myocardial infarction
  • Heart failure
  • Diabetes

Perindopril is prescribed for the treatment of hypertension caused by any reason, including kidney problems. With stable coronary heart disease, this drug reduces the risk of first and repeated heart attack. It is especially often prescribed for patients with type 2 diabetes. Perindopril is the only ACE inhibitor whose effectiveness has been proven to prevent re-stroke. It inhibits the development of senile dementia, allows patients to retain memory, clear thinking and concentration of attention longer.

!  Andipal instructions for use, what helps, price and analogues

Perindopril alone moderately lowers blood pressure, acts smoothly for 24 hours, and is usually well tolerated. In overweight people and patients with diabetes, it increases the sensitivity of tissues to insulin, a beneficial effect on metabolism. Perindopril is often used along with other medicines for hypertension and cardiovascular diseases. This drug is not suitable in situations where you need to quickly lower the pressure, stop the hypertensive crisis.

Perindopril is usually well tolerated, but sometimes causes side effects, like any other medication. Below is a table that may come in handy. The symptoms listed in it are experienced by 1-10% of patients who are treated with this drug.

Indications for use are narrow-profile for a therapeutic hospital due to the specificity of the therapeutic effect of the drug Perindopril:

  • increased individual sensitivity, acquired or hereditary intolerance to the constituent components of the pharmaceutical preparation or the entire group of angiotensin-converting enzyme inhibitors;
  • pregnancy period;
  • lactation or breastfeeding;
  • angioedema of hereditary or idiopathic origin;
  • the drug is not used in pediatric practice (before reaching the age of 18 years).

Separately, it is worth noting that there are a number of pathological conditions when the use of Perindopril is not completely safe and requires constant diagnostic monitoring of all kinds of indicators of the body with the conditions of a medical hospital. The list consists of the following diseases:

  • aortic or mitral stenosis;
  • constrictive pericarditis;
  • leukopenia;
  • heavy autoimmune nosological units of connective tissue (in particular systemic lupus erythematosus or scleroderma);
  • hyponatremia;
  • the presence of a transplanted donor kidney;
  • hypertrophic cardiomyopathies;
  • thrombocytopenia;
  • cerebrovascular disease;
  • obliterating atherosclerosis or narrowing of the lumen of blood vessels of other origin (especially the bed that feeds the heart muscle);
  • bilateral stenosis of the renal arterioles;
  • hyperkalemia
  • moderate or severe renal failure;
  • dehydration and exicosis.

The pharmaceutical preparation is used orally at one time (1 time per day). Treatment usually begins with a starting dosage of 1-2 mg per day. Further, depending on the indications for therapy, the instructions for use of Perindopril are somewhat different:

  • with congestive heart failure, conservative rehabilitation continues with the optimal dosage of 2-4 mg per day;
  • arterial hypertension can be treated with higher amounts of medication taken, with this pathology, 4-8 mg per day are used, the dosage should be increased gradually, over 3-4 weeks;
  • Renovascular hypertension can be treated at 2 mg per day;
  • stroke prevention is carried out according to a special scheme: first, 2 mg per knock for 2 weeks, and then 4 mg per day for the same length of time;
  • therapy of stable coronary heart disease begins with a starting dose of 4 mg per day for 2 weeks, and then the amount of the drug taken increases to 8 mg per day.

Reliable clinical cases of overdose of a pharmaceutical drug are known, which, as a rule, are manifested by the following list of symptoms:

  • excessive decrease in blood pressure;
  • shock
  • stupor;
  • bradycardia;
  • electrolyte imbalance;
  • renal failure.

There is no specific antagonist for the pharmaceutical product of the pharmaceutical product. With this complex of adverse effects of treatment, which accompanies increased plasma concentrations of active components, symptomatic therapy is used. The following medical actions are effective:

  • gastric lavage;
  • horizontal position with a raised lower end to restore blood pressure;
  • the use of enterosorbents;
  • correction of water-electrolyte balance by isotonic sodium chlor >

This modern drug in addition to perindopril contains the substance amlodipine. The latter belongs to the group of calcium channel blockers. The pharmacological effect of amlodipine is primarily that it has an antihypertensive effect due to a decrease in vasodilation of blood vessels and OPSS. The use of this drug reduces the oxygen demand of the heart muscles, promotes the expansion of blood vessels in ischemic zones, and delays the development of angina attacks.

The use of the drug “Prestance” by elderly people suffering from arterial hypertension reduces the risk of myocardial infarction. There is perindopril amlodipinokolo 500-600 rubles for 30 tablets of 10 mg 5 mg. This, of course, is quite expensive.

The means of this group are considered by both doctors and their patients to be effective and efficient. According to many patients, Prestarium A is tolerated by patients slightly better than Perindopril Erbumin. Doctors and patients explain this primarily by the fact that the first drug is manufactured mainly by foreign companies. The simple “Perindopril” is produced at most by domestic manufacturers. Therefore, the quality of it, according to many doctors and patients, is worse.

The advantages of all drugs based on perindopril arginine or erbumin patients include convenience. You need to drink such medicines only once a day. They begin to act quickly enough. These funds do not have any too unpleasant side effects.

Analogues

Instead of this fixed asset, patients in some cases can use substitutes such as:

Prestarium Arginine Combi;

All these pills are quite effective and effective. But you should take them, of course, only after consulting with your doctor first.

We examined preparations containing in their composition the main active ingredient of perindopril arginine. There are a small number of them on the Russian market. But there are analogues of these medicines with the main active substance in the form of erbumin salt. They belong to the same pharmacotherapeutic group and have the same pharmacodynamics. To analogues containing erbumin include:

    Analogues of perindopril substance. There are also other ACE inhibitors:

  • zofenopril – is part of the drug Zokardis in an amount of 7,5 mg;
  • captopril – is part of Blockordil, Captopril, Kapoten, Angiopril and others;
  • lisinopril – is found in the preparations Dapril, Diropress, Diroton, Iramed;
  • ramipril – Amprilan, Dilaprel, Corpril, Pyramil preparations;
  • spirapril – contained in the drug Kvardropril;
  • trandolapril – is part of Gopten capsules.
  • Co Parnawel;
  • Ko-Perineva;
  • Co-prenaissance;
  • Perindapam;
  • Perindide.
  • Amlopress;
  • Dalnev;
  • Parnawel Amlo.

The drug belongs to the pharmaceutical group of angiotensin-converting enzyme inhibitors, because technically all drugs of this subunit of the classification of antihypertensive drugs can be used as analogues of Perindopril. Most often, with individual contraindications, the therapeutic effect is replaced by the following drugs: Hypernik, Stopress, Noliprel, Prestarium A, Perineva, Prestanz.

Separately, it should be noted that Perindopril, due to its breadth of therapeutic effects and pharmacological action, is abundantly used to create combined pharmaceutical preparations. The most popular among this series are:

  • Perindopril PLUS Indapamide is a drug in which the therapeutic effects of Perindopril are supplemented with a diuretic component. The new active component blocks the reverse absorption of sodium, chlorine and water ions, selectively inhibits the activity of calcium channels and reduces the total peripheral resistance of blood vessels. A positive feature of this combination of pharmaceutical substances is a well-defined hypotensive effect that does not depend on the position of the body in space and the age of the patient. Also, the effect of this drug is not accompanied by reflex tachycardia.
  • Perindopril Indapamide Richter is an enhanced form of the previous analogue. The effect of the drug lasts for 24 hours, and persistent therapeutic effects develop in less than a month after conservative treatment. It is worth emphasizing that the cessation of medical rehabilitation when using this form of the drug is not accompanied by withdrawal syndrome, which sometimes is extremely difficult.
  • Perindopril Arginine is a unique drug of its kind, because the components of the antihypertensive agent are supplemented with a conditionally essential amino acid, the main role of which is to be a source of NO synthases in the production of endogenous nitric oxide. The latter is an extremely active mediator in the pathophysiological sense. In this context, the most important are its vasodilation abilities and regulatory effects on smooth muscle tone. Thus, the hypotensive effect of the drug covers a much wider mechanism of action than Perindopril in its pure form. It should be noted that this drug combination does not extend the list of side effects of use, since arginine is part of the natural metabolism of the human body.
  • Amlodipine Perindopril is a pharmaceutical preparation, which includes another blocker of slow calcium channels – a derivative of dihydropyridine. In addition to the antihypertensive effect, Amlodipine also has an antianginal effect, since, by binding to dihydropyridine receptors, it reduces the transmembrane current of calcium in the smooth muscle cells of the coronary and peripheral channels. This mechanism of action and the produced consequences of its use put this drug in first place among Perindopril analogues when it is indicated for the treatment of coronary heart disease and angina pectoris in particular.
  • Perindopril-Mick is a Belarusian analogue of a domestic pharmaceutical product. Its key feature is the use of the perindopril tertbutylamine salt (a compound with erbumin is used in the traditional form of the drug). Due to this fact, the drug reduces pressor effects on the vascular wall (including adrenergic), which manifests itself as an angioprotective effect. It should also be noted that the therapeutic effects of this combination extend to peripheral tissues to a greater extent – they are sensitized to insulin, and therefore glucose metabolism proceeds with greater intensity.

The drug “Lisinopril”

With heart failure, this medicine is drunk a little differently. In this case, the initial dose is only 2,5 mg. Then every 5 days the amount of the drug used is increased by another 2,5 mg. The maximum dose for such patients is 20 mg.

You can drink “Lisinopril” and people who have had a heart attack. In this case, the doctor usually prescribes 5 mg of the drug in the early days. Further, the dosage is increased to 10 mg per day (gradually). The course of treatment with the drug for patients after a heart attack is at least 6 weeks.

allergic to dihydropyridines;

When buying a means of “Lisinopril” it is worth paying attention to where it was manufactured and packaged. It is better if it will be the same place. This medicine is usually made from quality ingredients. But during packaging, it often happens that third-party components are added to it to receive large profits.

If we talk about a specific manufacturer, then Lisinopril, manufactured by Alsi, in pink packaging, received very good reviews. Patients are extremely advised not to buy the drug produced in the Republic of Macedonia and packaged in the suburbs (in yellow packets). This medicine may not even lower the pressure, but very much raise it. And this, in turn, is fraught with serious trouble. Especially for the elderly.

Perindopril arginine

Medical Knowledge Base

The above scientific information containing a description of the active substances of drugs is generalizing. The information contained on the site should not be used to make an independent decision on the possibility of using the presented medications and cannot serve as a substitute for face-to-face consultation with a doctor.

Perindopril arginine is the main active ingredient of this drug, which is an ACE inhibitor (used in the treatment of cardiovascular diseases).

Before the appearance of arginine in the 2000s, the main active ingredient in the preparations of this type was perindopril erbumin. In modern preparations, erbumin salt is also used along with arginine salt.

The action of drugs with these salts is equally effective. This has been proven by studies involving more than 50 patients.

The dosage, indications and effect of both tablet options are the same. However, some patients may experience better tolerance and a more pronounced effect from the use of drugs with the arginine salt of perindopril. It depends on the individual tolerance of the active substances by the patient.

The price of tablets may also vary depending on the manufacturer. The choice of the drug remains with the attending physician, who relies on his practical experience, and the patient’s clinical analyzes.

It costs “Arginine Combi” about 350 p. for 30 tablets.

The drug containing indapamide and perindopril erbumin is called “Co-Pyrenev.” It has the same effect on the patient’s body as Arginine Combi. But such a medicine also costs a little cheaper. For 30 tablets of Ko-Perinev 4 mg, you need to pay about 260 rubles.

Both drugs containing perindopril indapamide are quite affordable, and it will not be difficult to purchase them if necessary. “Arginine Combi” and “Ko-Perineva” are available in almost any pharmacy.

In tablets Prestarium A, the active substance is perindopril arginine. It is an ACE inhibitor combined with the amino acid arginine. In the name of the drug, A means arginine. Before the appearance of arginine salt, perindopril erbumin was used. Ergumin salt is still contained in analogues of other manufacturers (Perineva, KRKA).

The effectiveness of perindopril has been proven in numerous studies involving more than 50 patients. In most of these studies, patients were prescribed erbumin salt. Perindopril arginine entered the market in the second half of the 000s. At first, doctors doubted that the new active substance would be just as effective.

Official recommendations allow the administration of perindopril in the form of both erbumin and arginine. Indications for use are the same. The choice of a specific medicine is at the discretion of the doctor. Information about the effectiveness of various drugs that doctors accumulate from their practical experience play a role. Analogs are cheaper than the original drug Prestarium. Articles in medical journals promote Perinev tablets for the treatment of elderly patients who need affordable drugs.

How to drink medicine

Indapamide is a diuretic substance widely used in the treatment of hypertension. Lowers blood pressure, not greatly affecting the frequency of urination. Preparations with this active substance are prescribed for people suffering from type I and type diabetes mellitus, renal failure, overweight, and elderly people with isolated systolic hypertension.

Often, this drug is prescribed in combination with perindopril to improve the quality of treatment, reduce the risk of stroke and heart attack. There are drugs that combine both active substances – perindopril and indapamide.

Noliprel A is the original drug. Launches its French pharmaceutical company Servier. The letter “A” in the name indicates the presence of arginine, not erbumin salt. The tool is a combination of an ACE inhibitor and a diuretic, which allows you to effectively fight cardiovascular diseases caused by various reasons. Active ingredients – perindopril arginine, indapamide.

There are also other Noliprel variants containing perindopril arginine salt and indapamide. They differ in price and quantitative content of active substances.

  1. Noliprel A Fort. Contains active substances: 5 mg perindopril arginine, indapamide – 1,25 mg. It is indicated for use by people with essential hypertension, type II diabetes to prevent the development of micro- and macrovascular complications from the cardiovascular system and kidneys.
  2. Noliprel A Bi-Fort. Active substance: 10 mg perindopril arginine, and 2,5 mg indapamide. Indications: patients suffering from essential hypertension.

Noliprel forte and noliprel also exist. But they contain perindopril erbumin as an active substance. All these drugs are aimed at treating one disease. Differences only in composition and price.

Messages on pharmaceutical forums unanimously reiterate the positive effect of the drug on blood pressure and heart function in general. Such an active ingredient of Perindopril can cope with serious pathology for a relatively short course of conservative therapy.

People who took the pharmaceutical drug respond extremely well, because in addition to the main therapeutic effects, it improves trophism and the delivery of useful nutrients to all peripheral tissues and organs, cleans the macrocirculatory bed, which cannot but affect the general well-being in a positive light .

Doctors’ reviews of Perindopril confirm the opinion of grateful patients from a professional point of view. However, there are several points that somewhat overshadow the opinion of qualified specialists. First of all, this is a frequent development of side effects during the course of drug treatment, because the incidence of adverse reactions is catastrophic large 1-10 percent.

Therefore, in therapeutic hospitals, Perindopril is increasingly being replaced by combined pharmaceutical components. So, for example, in combination with arginine, the number of adverse effects of conservative treatment does not increase, and the therapeutic effect, on the contrary, is irresistibly increasing.

The price of Perindopril in the Russian Federation is 153 rubles, in Ukraine the drug can be purchased for 50-70 hryvnia.

The price of Perindopril Arginine is slightly different in both countries. So living in a federal state allows you to purchase a drug for about 200-250 rubles. Ukraine, in this regard, pleases somewhat more, because the price of Perindopril in combination with an amino acid practically does not differ from the usual form of the drug (50-70 hryvnias).

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Detonic for pressure normalization

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Like Prestans, this product also contains both amlodipine and perindopril. The difference between Dalnev and Prestance is that this medicine is made on the basis of erbumin rather than arginine. It costs “Dalnev” about 480 rubles for 30 pcs. 5 mg 8 mg.

This medicine can also be a good substitute for Perindopril. The price for it, as well as for Lisinopril, is very low. You can buy a package of Enalapril medicine with 30 tablets of 5 mg, for example, for 15-20 rubles. This remedy is used both for high blood pressure and heart failure.

In case of arterial hypertension, Enalapril is usually prescribed to the patient in an amount of 5 mg per day. In this case, the patient is placed under medical supervision for 3 hours until the pressure stabilizes. After a couple of weeks, the doctor increases the dose to 10 mg. Then the amount of the drug taken by the patient can be gradually increased to 40 mg.

In heart failure, this medicine is first taken in an amount of 2,5 mg per day. Then every 4 days the dose is increased by 5 mg. You can increase the amount of the drug used for treatment to no more than 40 mg per day.

You can not drink this medicine also to pregnant women. This remedy is not prescribed for children under 18 years of age. It can affect their body extremely negatively.

So, Captopril is a good substitute for Perindopril. Indications for use are the same. But this drug should not be drunk if:

impaired liver function;

renal artery stenosis;

This medicine is not prescribed, as well as Perindopril, also during lactation and during pregnancy. You can not take it and persons under 18 years of age.

1579274 - Overview of the drug Perindopril arginine and its features

People with high blood pressure call this medicine a real ambulance. In addition to the quick and effective action, the advantages of Captopril include the fact that, unlike perindopril-based products, it is dispensed in pharmacies without a doctor’s prescription. However, drinking this medicine is uncontrolled, or just for prevention, nevertheless, according to many patients, is not worth it.

Perindopril is not a very powerful cure for pressure, and this is noted by patients in their reviews. But it acts gently and rarely causes side effects, except for dry cough.

I have been taking perindopril erbumin (Perineva) for 3 months now. A month after the start of treatment, my pressure was equalized during the day, kept no higher than 130/80 mm RT. Art. And before, every day rose in the evening.

You were able to successfully pick up a medicine. Please note that it does not eliminate the causes of the disease, but only muffles the symptoms. Hypertension causes an unhealthy lifestyle. It gradually destroys blood vessels. If you continue in the same vein, in a few years the state of the vessels will worsen. More and more powerful pills will be needed. In the end, and they will not be able to take pressure under control. Normalize your lifestyle in middle age, if you want to still live in retirement.

The cardiologist prescribed me perindopril. I have been treating this drug for the 4th month already. Typically, the pressure is not higher than 130/85 mm RT. Art. But when the weather changes, it rises, despite taking pills. It comes to 170/110 mm Hg. Art., headache and other symptoms. I want to switch to some other drug, a stronger one.

Study the article “Causes of Hypertension and How to Eliminate Them”, then be examined and follow the recommendations. The transition to a healthy lifestyle is the main treatment for hypertension. And any pills only complement it. You can continue to lead a sedentary lifestyle and eat garbage. But in this case, after a few years, no medicine will be able to take your pressure under control. This can happen even before retirement. And what will you do then?

I took perindopril for six months from hypertension. These pills were kept well under pressure; there has never been a sharp increase. But pestering a constant cough. The doctor said go to losartan and add a diuretic. Now I’m starting to be treated with a new drug. How good such a replacement will be – I don’t know yet.

The drug Losartan belongs to the group of angiotensin-II receptor blockers. If perindopril causes a dry cough, then this medicine is standardly prescribed in return for it. How well the new drug will help is impossible to predict in advance. To date, pressure pills are selected by trial and error, because a more accurate method does not exist. Each patient has his own individual reaction. Over time, genetic research will make it possible to accurately predict, but this is still a long way off.

Terms of sale

The drug is classified as potent and is listed in List B of the International Register of Pharmaceuticals, therefore, the sale of Perindopril is carried out only on a receptor form certified by the personal signature and seal of the attending physician.

Save Perindopril should be a dry place inaccessible to children, which is protected from direct sunlight. The temperature regime of optimal storage should not exceed 25 degrees Celsius.

special instructions

When using ACE inhibitors and Perindopril in particular, there is a risk of developing arterial hypotension, headache, dizziness and visual impairment, therefore, during conservative treatment, you should abandon self-driving and other activities that require increased attention, speed and clarity of motor reactions .

Tatyana Jakowenko

Editor-in-chief of the Detonic online magazine, cardiologist Yakovenko-Plahotnaya Tatyana. Author of more than 950 scientific articles, including in foreign medical journals. He has been working as a cardiologist in a clinical hospital for over 12 years. He owns modern methods of diagnosis and treatment of cardiovascular diseases and implements them in his professional activities. For example, it uses methods of resuscitation of the heart, decoding of ECG, functional tests, cyclic ergometry and knows echocardiography very well.

For 10 years, she has been an active participant in numerous medical symposia and workshops for doctors - families, therapists and cardiologists. He has many publications on a healthy lifestyle, diagnosis and treatment of heart and vascular diseases.

He regularly monitors new publications of European and American cardiology journals, writes scientific articles, prepares reports at scientific conferences and participates in European cardiology congresses.

Detonic