So what is fibrate? This is a group of pharmaceuticals that helps lower plasma fat levels, as well as normalize lipid metabolism with it. For the first time, this medicine based on fibroic acid was used in the treatment of people in 1962. If we talk about today’s diversity of this group, then their number corresponds to ten.
Very often, doctors prescribe statins as a concomitant drug. Both of them have a beneficial effect on the normalization of the fat content in the patient’s body. It is important that only a doctor can prescribe the medicine correctly!
Fibrates are prescribed to normalize fat metabolism in the body.
Influence on the body
During the course of treatment, blood circulation and metabolism are restored. If diseases of the cardiovascular system occur against the background of diabetes mellitus, then their administration avoids various complications. Also, drugs are indicated for people with gangrene and retinopathy.
Xanthine derivatives: teufillin, aminophylline (aminophylline).
phosphodiesterase and purine inhibitors
receptors, increase cAMP levels.
reduce the concentration of Ca ions and cause
vasodilating effect of blood circulation
in internal organs (including
kidneys) is improving. Thanks to this
action, filtration ability
glomeruli increases, urine flow through the nephron
accelerates, the contact time of Na ions with
renal tubule epithelium is reduced
and, as a consequence of this, decreases
from the body of water, sodium ions and chlorine.
pain, dizziness, central nervous system agitation,
convulsions, tachycardia, bradycardia (with
intravenous administration), nausea ,. vomiting
pain in the epigastric region.
The mechanism of action of fibrates
(antihypertensive) agents are substances
different structure, therefore more often
classified by mechanism of action,
not by chemical structure.
funds lower blood pressure
various mechanisms. Pressure in
any piping system with which
conditionally it is possible to compare CCC, depends on
the volume of fluid in it, the width of the lumen
pipes (vessels) and pump power
(hearts). Antihypertensive drugs reduce
circulating blood volume, increase
vascular lumen width and thereby
reduce total peripheral resistance
(OPS). They also reduce the strength of the heart.
contractions and cardiac output.
The mechanism of action of fibrates is based on the high activity of the enzyme (lipoprotein lipase), which breaks down LDL and VLDL, while the hepatic metabolism is restored and increased fat metabolism. All this is aimed at reducing the risk of emergence and complications of vascular atherosclerosis, which leads to disability and early death due to the accumulation of cholesterol in all major, large vessels. And the most dangerous complications of this disease (cerebral stroke and heart attack) can be fatal.
Fibrates (derivatives of fibroic acid) have a multiple effect on lipid formation processes. They reduce the synthesis of triglycerides included in VLDL and increase the activity of the LPL enzyme, which breaks down VLDL. These two effects lead to a decrease in blood levels of VLDL and triglycerides.
Fibrate therapy is accompanied by a clear increase in HDL. It was noted that fibrates have a wide range of favorable non-lipid (pleiotropic) effects, among which anti-inflammatory, antioxidant, anticoagulant properties, and the effect on vascular tone endothelial regulation are of particular interest.
Osmotic diuretic: attracts.
effect due to limitation
reabsorption of water in the proximal
tubules and increased osmotic
plasma pressure. Due to counteracting
osmotic force volume increases
have urine with excretion. Relevant
an increase in urine flow rate reduces
the time of her contact with the tubular epithelium,
which reduces subsequent reabsorption
cerebral and pulmonary edema. Expression
dehydrating effect is manifested
only with filtration ability
Decreased intracranial and intraocular
pressure is associated not only with diuretic
effect, but also with a central effect
(activation of osmoreceptive fields
hypothalamus under the action of hypertonic
solution). Relieving seizures, effect
due to strong dyshydrogenation
action and decreased intracranial
pain, dizziness, dyspepsia,
dehydration (thirst, cyxos in the mouth),
hypernatremia, osmotic diarrhea.
Heart failure and
pulmonary edema due to the fact. what u
patients with severe disease
kidneys, urine may not form
even with osmotic load, and in this
hypertonic solution causes
increase in circulating blood volume.
diuretics: furosemide (lasix), ethacrine
acid (yregite), bumetanide (bufenoks),
torsemide (used abroad).
combined transport system Na, K,
Cl- in the apical (facing the lumen
tubule) membrane thick ascending
parts of the Henry loop, i.e. reduce reabsorption
Na, Cl-. Increased prostacyclin levels
(Pg. I2) in the coronary and peripheral
vessels helps reduce pressure.
lung and brain cirrhosis. Using
associated with the ability to reduce volume
(Bcc) and reduce stagnation in
small and large circle of blood circulation.
BCC, allows to reduce peripheral
vascular resistance (OPSS) and
lower blood pressure.
Antihypertensive effect is enhanced
due to the accumulation in the vessels of endogenous
PG! 2, with vasodilator
properties. Anion poisoning
Efficacy for bromide poisoning,
fluorides, iodides, due
the ability of the latter to reabsorb
in the thick section of the ascending part of the loop
Henle (in the scope of loop
metabolic alkalosis, hyperuricemia
and the provocation of gout attacks,
ototoxic effect (especially in
combined with antibiotics from the group
Preparations from the fibrate group are indicated for individuals with type II, type III, type IV, type V hyperlipidemia, as well as those who have low HDL cholesterol in combination with high LDL cholesterol and high triglycerides. Fibrates reduce triglyceride levels by 30-50%, LDL by 10-15% and increase the concentration of HDL by 10-20%
iron – a group of medicinal
products containing salts or complexes
bivalent and trivalent iron, and
their combinations with other drugs. IN
mainly used to treat and
prophylaxis of iron deficiency anemia.
classifications merged under code
drugs in this group
must contain at least 30 mg of the main
active substance in terms of
elemental iron, otherwise
they cannot be used in treatment
iron deficiency states and will
classified as vitamins or
general tonic agents.
this category of drugs
can be divided into several main
groups: salt-based preparations
ferrous and ferric iron,
various iron complexes
and combination agents. Preparations
of iron salts are prescribed only
durules, tardiferon (folate sulfate
acid). Two tablets are used
per day (morning and evening), half an hour before
food, drink a glass of water.
Hemofer, Ferronal, Totem. Accept
30 minutes before meals, between meals, s
vitamin fruit juice
C, to improve the absorption of iron.
available in capsules, taken 1 time
in a day. With heavy menstruation
taken 2 days before and after menstruation
1 capsule per day
Ferrogradumet, Ferroplex, etc.
Lek taken with food, you can
mix with fruit juices and mashed potatoes.
You can divide the daily dose into
several tricks can be taken in one
– this is a solution, it is taken before meals
1 bottle per day in two divided doses.
1 capsule 1 hour before a meal.
– the dose is calculated individually
according to the table, before use they recommend
test for adverse reactions
iron are shown at :
conditions (main indication);
intolerance to cow’s milk;
acute or prolonged
iron can be caused :
the intake of iron in the fetus
(with feto-fetal and feto-maternal
transfusion), child or adult
(malabsorption syndrome, inflammatory
processes in the intestine, against the background of taking
tetracycline antibiotics and
massive or chronic
blood loss (bleeding, helminths
infestations, nasal hemorrhages, juvenile
uterine bleeding, prolonged
hematuria and others);
increased iron consumption (period
diseases and others).
Fibrates are hypolipidemic agents, and they are indicated for the use of the following categories of people:
- people with high cholesterol;
- at risk due to hereditary indicators;
- patients for whom diet did not help lower cholesterol.
Fibrates are contraindicated in people with gallstone disease, liver or kidney failure, and others. Pregnant women and children under 18 years of age should also not take these drugs. Older people and alcohol abusers should take them on a limited basis.
They can not be used with nephro and hepatotoxic drugs, anticoagulants. Properly selected dosage contribute to the easy perception of patients. Side effects from fibrates are diagnosed in 10% of people.
Summing up, it is worth noting that modern technology has significantly reduced the side effects that occur during treatment. This class of drugs is a good tool for normalizing cholesterol, is a prophylactic for atherosclerosis, and also has a tonic effect.
The independent use of fibrates can bring the main systems and organs to a pathologically dangerous state. The correct combination of it with a diet (low in fat) and moderate physical activity for a long time will prolong life and health.
The list of types of fibrates is large, so we will get acquainted with its main representatives:
- Clofibrate – this medicine was previously used as a prophylactic against coronary sclerosis, angiopathy (diabetic). This is the very first form of this orientation was first used for treatment in the sixties. Currently, it is not used, since the list of side effects is very large. The most dangerous of them is myositis.
- The next representative – Gemfibrozil, also has a number of side effects. This capsule or tablet preparation is available in two forms of 450 and 650 mg.
- Fenofibrate is recognized as a universal remedy for lowering cholesterol. In addition to non-lipid actions, it has an anti-inflammatory effect, an antioxidant and tonic.
A huge number of well-known pharmaceutical companies produce various chemical combinations of this group. In post-Soviet countries, fibrates are replaced with statins.
How to use
Instructions for the use of fibrates: the course of treatment with these medications is long. Depending on the patient’s individual indicators, doctors prescribe 2-3 tablets or capsules per day. Their intake is necessarily combined with a special diet and periodic clinical and laboratory studies. To enhance the effect, tablets are taken before meals or during.
Fibrate Dosage Table
When using them, discomfort may occur in the gastrointestinal tract, headache, rash, dermatitis, dry mouth, dyspepsia, anemia may occur. There are problems with potency and decreased libido. With an independent (without consulting a doctor) appointment, complications and disturbances in the work of the most important organs and systems (central nervous system, heart, liver, bone skeleton, muscles) are likely.
The main drugs of fibrates, their benefits and harms
Detonic – a unique medicine that helps fight hypertension at all stages of its development.
The complex effect of plant components of the drug Detonic on the walls of blood vessels and the autonomic nervous system contribute to a rapid decrease in blood pressure. In addition, this drug prevents the development of atherosclerosis, thanks to the unique components that are involved in the synthesis of lecithin, an amino acid that regulates cholesterol metabolism and prevents the formation of atherosclerotic plaques.
Detonic not addictive and withdrawal syndrome, since all components of the product are natural.Detailed information about Detonic is located on the manufacturer’s page .
Of this group, gemfibrozil is best studied. Its use leads to a significant reduction in triglycerides and, to a lesser extent, cholesterol. A distinctive feature of gemfibrozil is the ability to increase HDL cholesterol in the blood. Long-term use of the drug (two years or more) due to its main effects ensures a decrease in blood lipids and, as a consequence, a decrease in the likelihood of developing myocardial infarction and death from it in type II hyperlipidemia.
Side effects of gemfibrozil:
Lipanor (ciprofibrate) has an effective long-term effect, starting from the twelfth week of treatment, reducing total cholesterol by 29%, triglycerides – by 42%. Treatment with lipanor allows you to restore the normal lipoprotein profile of blood plasma by reducing the content of VLDL and LDL with a simultaneous increase in the number of HDL.
The decrease in cholesterol and triglycerides under the action of lipanor is accompanied by a significant decrease in the level of fibrinogen and an increase in physiological fibrinolytic activity. Unlike preparations of the fibrate group, long-term use of lipanor is well tolerated, there is no significant increase in the risk of stone formation in the gallbladder.
Side effects of using lipanor:
|200 mg x
2-3 times / day
|400 mg per day
(slow release form)
|Gemfibrozil||600 mg x
2 times / day
|Maybe 900-1500 mg / day|
|100 mg x 1-2 times / day||200 mg / day possible|
|200 mg x
1 time / day
|In the form of a micronized form 200 mg 1 time / day|
angiotensin II receptors – one of
new classes of drugs to normalize
blood pressure. Names
preparations of this group end
to “-artan.” Their first representatives
synthesized in the early 90s of the twentieth
centuries. Receptor blockers
angiotensin II inhibit activity
systems, thereby contributing to the whole
a number of positive effects.
indications for using blockers
angiotensin II receptors serve as AH and
chronic heart failure.
They are significantly inferior in their activity
to the application
substances of this group can only be
the appointment of the attending physician. Exist
a few cases in which it would be
reasonable use of receptor blockers
Hypertension. This disease is considered
The main indication for the use of sartans.
This is due to the fact that blockers
angiotensin 2 receptors do not exert
negative effects on metabolism,
do not provoke erectile dysfunction,
do not worsen bronchial patency.
The action of the drug begins already
two to four weeks after
deficiency receptor blockers
angiotensin 2 inhibit action
systems whose activity provokes
development of the disease. Nephropathy. Due to diabetes and
arterial hypertension occur
the kidneys. Angiotensin Receptor Blockers
2 protect these internal organs and do not
allow you to output too much protein