Andipal instructions for use, what helps, price and analogues

Heading ICD-10ICD-10 disease synonyms
G43 MigraineMigraine pain
Hemicrania
Hemiplegic Migraine
Migraine-like headache
Migraine
Migraine attack
Serial headache
G44.1 Vascular headache, not elsewhere classifiedArteriohypotonic headache
Vasogenic pains
Vasomotor headache
Headache of vascular origin
Headache of vascular origin
I10 Essential (primary) hypertensionHypertension
Arterial hypertension
Crisis arterial hypertension
Arterial hypertension complicated by diabetes
Hypertension
Sudden increase in blood pressure
Hypertensive circulatory disorders
Hypertensive state
Hypertensive crises
Hypertension
Arterial hypertension
Malignant hypertension
Essential hypertension
Hypertonic disease
Hypertensive crises
Hypertensive crisis
Hypertension
Malignant hypertension
Malignant hypertension
Isolated systolic hypertension
Hypertensive crisis
Exacerbation of hypertension
Primary arterial hypertension
Transient arterial hypertension
Essential arterial hypertension
Essential arterial hypertension
Essential hypertension
Essential hypertension
I15 Secondary hypertensionHypertension
Arterial hypertension
Crisis arterial hypertension
Arterial hypertension complicated by diabetes
Hypertension
Vasorenal hypertension
Sudden increase in blood pressure
Hypertensive circulatory disorders
Hypertensive state
Hypertensive crises
Hypertension
Arterial hypertension
Malignant hypertension
Symptomatic hypertension
Hypertensive crises
Hypertensive crisis
Hypertension
Malignant hypertension
Malignant hypertension
Hypertensive crisis
Exacerbation of hypertension
Renal hypertension
Renovascular arterial hypertension
Renovascular hypertension
Symptomatic arterial hypertension
Transient arterial hypertension
I73.9 Peripheral Vascular Disease, unspecifiedAngiospasm
Vasospasm/vasoconstriction
Vasospastic Disorders
Violation of venous microcirculation
Circulatory disorders
Peripheral circulation
Peripheral circulatory failure in the lower and upper extremities
Peripheral Artery Occlusion
Fontaine stage III-IV occlusive disease of peripheral arteries
Peripheral vascular insufficiency
Peripheral vascular lesions
Peripheral vascular disorder
Peripheral circulation disorder
Arterial spasm
Vasospasm
Functional lesions of the peripheral arteries
Chronic obliterating endarteritis
Chronic obliterative disease of the vessels of the lower extremities
Chronic occlusive artery disease
K59.8.1 * intestinal dyskinesiaPain syndrome for smooth muscle spasms
Pain syndrome with smooth muscle spasms (renal and biliary colic, intestinal spasm, dysmenorrhea)
Pain syndrome with spasms of smooth muscles of internal organs
Pain syndrome with spasms of smooth muscles of internal organs (renal and biliary colic, intestinal spasm, dysmenorrhea)
Intestinal hypokinesia
Hypotonic colon dyskinesia
Childhood colic
Gastrointestinal Dyskinesia
GI dyskinesia
Gastrointestinal dyskinesia with atony
Colon dyskinesia
Gastrointestinal spasm
Intestinal colic
Colic in young children
Colic in newborns
Spastic intestinal dyskinesia
Spastic dyskinesia of the colon
K82.8.0 * Dyskinesia of the gallbladder and biliary tractBiliary obstruction
Biliary reflux gastritis
Biliary Reflux Esophagitis
Biliary sludge
Pain syndrome for smooth muscle spasms
Pain syndrome with smooth muscle spasms (renal and biliary colic, intestinal spasm, dysmenorrhea)
Pain syndrome with spasms of smooth muscles of internal organs
Pain syndrome with spasms of smooth muscles of internal organs (renal and biliary colic, intestinal spasm, dysmenorrhea)
Hypermotor biliary dyskinesia
Gallbladder hypokinesia
Hypomotor dyskinesia of the gallbladder
Biliary dyskinesia
Gallbladder dyskinesia
Biliary Dyskinesia
Biliary colic
Gall reflux
Bile secretion
Violation of the outflow of bile
Subacute and chronic biliary tract disease
Spasm of the biliary tract
Biliary tract spasm
Spastic biliary dyskinesia
Spastic dyskinesia of the gallbladder
Spastic conditions of the gastrointestinal tract
N23 Renal colic, unspecifiedRenal colic pain
Pain syndrome for smooth muscle spasms
Pain syndrome with smooth muscle spasms (renal and biliary colic, intestinal spasm, dysmenorrhea)
Pain syndrome with spasms of smooth muscles of internal organs
Pain syndrome with spasms of smooth muscles of internal organs (renal and biliary colic, intestinal spasm, dysmenorrhea)
Renal colic
Ureteric colic
Renal colic
Renal colic with urolithiasis
Kidney stone disease
Smooth muscle spasm in diseases of the urinary system
Urinary tract spasm
Ureter Spasm
Ureter Spasm
Urinary tract cramps
Urinary cramps
N94.6 Dysmenorrhea, unspecifiedAlgodismenorea
Algomenorrhea
Pain syndrome for smooth muscle spasms
Pain syndrome with smooth muscle spasms (renal and biliary colic, intestinal spasm, dysmenorrhea)
Pain syndrome with spasms of smooth muscles of internal organs
Pain syndrome with spasms of smooth muscles of internal organs (renal and biliary colic, intestinal spasm, dysmenorrhea)
Pain during menstruation
Painful irregular menstruation
Menstruation pain
Menstruation pain
Dysalgomenorrhea
Dysmenorrhea
Dysmenorrhea (essential) (exfoliative)
Menstrual disorder
Menstrual Krampi
Menstruation painful
Metrorrhagia
Violation of the menstrual cycle
Menstrual irregularities
Primary dysalgomenorrhea
Prolactin-dependent menstrual irregularities
Prolactin-dependent menstrual dysfunction
Menstrual disorders
Spastic dysmenorrhea
Functional disorders of the menstrual cycle
Functional disorders of the menstrual cycle
R25.2 Cramp and SpasmPain syndrome for smooth muscle spasms
Pain syndrome with smooth muscle spasms (renal and biliary colic, intestinal spasm, dysmenorrhea)
Pain syndrome with spasms of smooth muscles of internal organs
Pain syndrome with spasms of smooth muscles of internal organs (renal and biliary colic, intestinal spasm, dysmenorrhea)
Painful muscle spasm
Mimic cramps
Muscle spasticity
Muscle spasms
Tetanus muscle spasms
Muscle cramps of central origin
Muscle spastic conditions
Muscle spasm
Neurological contracture with cramping
Night cramps in limbs
Night cramps in the legs
Cramps at night
Symptomatic convulsive condition
West syndrome
Smooth muscle spasm
Smooth muscle spasm
Spasm of vascular smooth muscle
Muscle spasm
Striated muscle spasm due to organic diseases of the central nervous system
Skeletal muscle spasm
Spasms of smooth muscles of internal organs
Muscle cramps
Skeletal muscle spasms
Spastic conditions of striated muscles
Spastic pain syndrome
Spastic condition of smooth muscles
Skeletal muscle spasticity
Muscle cramp
Convulsions
Cramps in the calf muscles
Seizures of central origin
Convulsive condition
Convulsive syndrome
Convulsive status in children
Tonic cramps
Folding knife phenomenon
Cerebral spastic syndrome
R52.9 Unspecified painObstetric and gynecological pain
Pain syndrome
Postoperative pain
Postoperative pain after orthopedic surgery
Inflammatory pain syndrome
Pain syndrome of non-cancer genesis
Pain after diagnostic procedures
Pain after diagnostic interventions
Pain after surgery
Pain after surgery
Pain after orthopedic surgery
Pain after injury
Pain after removal of hemorrhoids
Pain after surgery
Pain syndrome with non-rheumatic inflammation
Pain syndrome in inflammatory lesions of the peripheral nervous system
Pain syndrome for diabetic neuropathy
Pain syndrome in acute inflammatory diseases of the musculoskeletal system
Pain syndrome in tendon pathology
Pain syndrome for smooth muscle spasms
Pain syndrome with smooth muscle spasms (renal and biliary colic, intestinal spasm, dysmenorrhea)
Pain syndrome with spasms of smooth muscles of internal organs
Pain syndrome with spasms of smooth muscles of internal organs (renal and biliary colic, intestinal spasm, dysmenorrhea)
Pain syndrome with injuries
Pain syndrome in injuries and after surgery
Pain in chronic inflammatory diseases of the musculoskeletal system
Pain with duodenal ulcer
Pain with gastric ulcer
Pain syndrome in peptic ulcer of the stomach and duodenum
Pain sensations
Pain during menstruation
Pain syndromes
Pain conditions
Painful leg fatigue
Sore gums when wearing dentures
Soreness of exit points of cranial nerves
Painful irregular menstruation
Painful dressings
Painful muscle spasm
Painful tooth growth
Pain
Pain in the lower extremities
Pain in the area of ​​the surgical wound
Postoperative pain
Body aches
Pain after diagnostic procedures
Pain after orthopedic surgery
Pain after surgery
Pain after cholecystectomy
Flu pain
Pain in diabetic polyneuropathy
Burn pain
Pain during intercourse
Pain during diagnostic procedures
Pain during therapeutic procedures
Cold sore pain
Sinusitis pain
Pain in injuries
Shooting pains
Traumatic pain
Pain
Postoperative pain
Pain after diagnostic procedures
Pain after sclerotherapy
Pain after surgery
Postoperative pain
Postoperative and post-traumatic pain
Post-traumatic pain
Pain when swallowing
Pain in infectious inflammatory diseases of the upper respiratory tract
Burn pain
Muscle trauma pain
Trauma pain
Tooth extraction pain
Traumatic pain
Pain due to smooth muscle spasm
Severe pain
Severe pain syndrome of traumatic origin
Non-malignant pain syndrome
Polyarthralgia with polymyositis
Postoperative pain
Postoperative pain
Postoperative pain
Postoperative pain
Post-traumatic pain
Post-traumatic pain syndrome
Torpid pain syndrome
Traumatic pain
Traumatic pain
Moderate pain
Moderate pain
Moderate pain

Composition and pharmacological properties

Combined drug with analgesic, antispasmodic and vasodilating effects due to the specific action of its components. The drug also has a hypotensive and antipyretic effect.

Metamizole sodium – NSAIDs (NSAIDs) of the pyrazolone derivative group, has anti-inflammatory, analgesic and antipyretic effects, the mechanism of action of which is due to the inhibition of cyclooxygenase (COX) and the blocking of prostaglandin synthesis from arachidonic acid, as well as the violation of painful extra- and proprioreceptive impulses, increased threshold thalamic centers of pain sensitivity, increased heat transfer.

Bendazole hydrochloride – has a vasodilating, antispasmodic, hypotensive effect, and also has a stimulating effect on the functions of the spinal cord and helps to restore the functions of peripheral nerves, has a moderate immunostimulating effect.

Papaverine hydrochloride – has a myotropic antispasmodic, hypotensive effect. It blocks phosphodiesterase, causes the accumulation of cyclic adenosine monophosphate (cAMP) and a decrease in the calcium content in the cell, relaxes the smooth muscles of blood vessels and internal organs.

andipal 12 - Andipal instructions for use, what helps, price and analogues

When taken orally, it is rapidly and completely absorbed. It is hydrolyzed in the intestinal walls to form an active metabolite. The action develops after 20-40 minutes and reaches a maximum after 2:00. Metabolized in the liver. It is excreted by the kidneys.

The release of the drug is arranged in the form of tablets of a cylindrical shape. The color of the tablets is white or yellowish. We list the components that make up Andipal and give the pharmacological properties of each substance in the form of a table.

The amount of substance in the tablet in grams

Influence on the body

Analgesic, anti-inflammatory and antipyretic

Expands blood vessels, relieves spasm and lowers blood pressure. It has a stimulating effect on the spinal cord. Excellent immunostimulant

Eliminates spasm, reduces conduction and excitability of the heart muscle

Sleeping pills, in small amounts – soothing

Stearic acid, starch, talc, calcium stearate

Andipal is used as a means to lower blood pressure, which has a mild hypotensive and soothing effect. However, its effectiveness is achieved only with certain indicators. Therefore, it is advisable to take the medicine not sporadically, during seizures, but according to systematic courses of therapy. The attending physician will help to compile them.

Shelf life

The main indicator for the use of Andipal is the elimination of spasm of smooth muscles of internal organs. Here is a list of diseases and symptoms in which the use of the drug is effective:

  • postcholecystectomy syndrome;
  • spasm of the bladder and ureters;
  • algodismenor;
  • spasm of cerebral vessels;
  • migraine;
  • biliary dyskinesia;
  • eye pain
  • renal, biliary and intestinal colic;
  • lesions of the trigeminal nerve;
  • pain in the chest that occurs when breathing;
  • essential and intracranial hypertension.

Moreover, he is well established as an adjuvant in pain in the postoperative recovery period.

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Due to the fact that Andipal is related to combination drugs, it is effective in use, however, it is quite specific. If the patient has the following diseases, the use of the drug is contraindicated.

  • liver and kidney dysfunction;
  • decreased muscle tone;
  • blood diseases;
  • hypotension;
  • increased blood clotting;
  • component intolerance;
  • pregnancy and lactation;
  • pathology of pigment metabolism;
  • tachyarrhythmias;
  • severe form of angina pectoris;
  • collapse;
  • heart failure;
  • angle-closure glaucoma;
  • hyperplasia of the prostate;
  • intestinal obstruction;
  • megacolon.

As you can see, the list of diseases in which the drug is contraindicated is quite large, from which it follows that a doctor’s consultation is necessary!

The drug is suitable for use within 2,5 years from the date of release. Date of manufacture is indicated on the box.

Pain syndrome associated with spasm of blood vessels or smooth muscles of internal organs.

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Known or suspected hypersensitivity to metamizole sodium salt, pyrazolone derivatives (butadione, tribusone, antipyrine) suspected acute surgical pathology; anemia of any etiology, cytostatic or infectious neutropenia; leukopenia agranulocytosis thrombocytopenia hepatoporphyria; glucose-b-phosphate dehydrogenase deficiency;

Severe heart failure, AV block. Arterial hypotension. Severe impaired liver and kidney function. Chronic nephritis with edema and impaired nitrogen excretory function of the kidneys. Gastric and duodenal ulcer, accompanied by bleeding. Diabetes. Hypotonic colitis habitual constipation traumatic brain injury;

Contraindications to the use of Andipal are:

  • Closed angle glaucoma. andipal 13 - Andipal instructions for use, what helps, price and analogues
  • Intestinal obstruction.
  • Hyperplasia of the prostate gland.
  • Age to 8 years.
  • Pregnancy and lactation.
  • Diseases of the blood and circulatory system.
  • Hypersensitivity to the components of the drug deficiency of glucose-6-phosphate dehydrogenase.
  • Severe renal or hepatic insufficiency.

Must be stored in a dry, dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children. Shelf life – 2 years 6 months.

Andipal tablets do not belong to means for systematic use. It is recommended to take the tablets of the drug only when migraine attacks or blood pressure is not more than 160 units higher and 110 lower. The drug can be attributed to “first aid”. Their intake quickly normalizes blood pressure, relieves headaches, which may appear as a result of high blood pressure or against a background of migraine attacks. Tablets are intended for internal use.

Detonic – a unique medicine that helps fight hypertension at all stages of its development.

Detonic for pressure normalization

The complex effect of plant components of the drug Detonic on the walls of blood vessels and the autonomic nervous system contribute to a rapid decrease in blood pressure. In addition, this drug prevents the development of atherosclerosis, thanks to the unique components that are involved in the synthesis of lecithin, an amino acid that regulates cholesterol metabolism and prevents the formation of atherosclerotic plaques.

Detonic not addictive and withdrawal syndrome, since all components of the product are natural.

Detailed information about Detonic is located on the manufacturer’s page www.detonicnd.com.

For adults

  • hypertensive vegetative-vascular dystonia;
  • migraine;
  • initial stage of hypertension;
  • headaches against osteochondrosis.

The drug is widely used in the early stages of the development of hypertension to reduce blood pressure, reduce symptoms.

For children

The drug is not intended for children, so in the instructions for use there is no information about the indications for children.

During pregnancy, taking any medication can harm the fetus, disrupt the normal course of pregnancy. Andipal tablets are no exception. They are contraindicated in pregnant and lactating mothers.

The main contraindications that do not allow taking Andipal tablets include:

  • intolerance to the composition;
  • myasthenia gravis;
  • blood pathology;
  • severe liver and kidney disease;
  • heart failure;
  • risk of developing a stroke or heart attack.

In the instructions for use, there are other contraindications to taking the drug, which you need to familiarize yourself with before taking it.

mild forms of hypertension;

hypersensitivity to the components that make up the drug;

15475628305c3def4e74c7d org - Andipal instructions for use, what helps, price and analogues

violation of AV conduction;

severe violations of the liver and kidneys;

andipal foto - Andipal instructions for use, what helps, price and analogues

pregnancy (I term);

In a dry, dark place.

Keep out of the reach of children.

Do not use after the expiry date printed on the package.

Form of issue and composition

Andipal is available in tablet form for internal use. The medication consists of papaverine hydrochloride (20 mg), metamizole sodium (250 mg), bendazole (20 mg) and phenobarbital (20 mg).

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The release of Andipal is arranged in the form of flat cylindrical tablets, slightly yellowish or white. In blister strip packaging contains from 10 to 30 tablets, which are placed in a cardboard box with instructions for use.

Pills1 table.
analgin0,25 g
dibazole0,02 g
phenobarbital0,02 g
papaverine hydrochloride0,02 g
excipients: starch; talc; stearic acid – a sufficient amount to obtain a tablet weighing 0,37 g

10 contour boxless pcs.

Interaction with other drugs and other types of interactions

X-ray contrast agents, colloidal blood substitutes, penicillin should not be used in the treatment of metamizole with sodium salt.

Chlorpromazine or other phenothiazine derivatives – the development of severe hypothermia is possible. Indirect anticoagulants, phenytoin, corticosteroids, indomethacin, ibuprofen – metamizole sodium salt increase the activity of these drugs by displacing them from the connection with the protein.

Glutetimide reduces the effectiveness of metamizole sodium salt.

Other non-steroidal anti-inflammatory drugs: their analgesic and antipyretic effects are potentiated and the likelihood of additive unwanted side effects increases.

Drugs that suppress bone marrow activity, including gold preparations: the likelihood of hematotoxicity increases, incl. development of leukopenia.

Methotrexate: Metamizole sodium salt in high doses can lead to an increase in the concentration of methotrexate in blood plasma and an increase in its toxic effects (primarily on the digestive tract and blood formation system).

Diuretics (furosemide): a decrease in the diuretic effect is possible.

Sedatives and tranquilizers (sibazon, trioxazine, valocordin, codeine, anaprilin, H 2 receptor blockers) enhance the analgesic effect of metamizole sodium salt. Tricyclic antidepressants (amisole, doxepin) disrupt the metabolism of metamizole sodium salt in the liver and increase its toxicity. Metamizole sodium salt enhances the sedative effect of alcohol.

Phentolamine, antihypertensive drugs (agents that affect the renin-angiotensin system), saluretics – when combined with bendazole, the antihypertensive effect is enhanced.

With levodopa, methyldopa – the weakening of the effects of these drugs.

With cardiac glycosides – a marked increase in the contractile function of the myocardium due to a decrease in the total peripheral vascular resistance; with adsorbents, astringents and enveloping agents – a decrease in the absorption of the drug from the gastrointestinal tract.

The effectiveness of the drug decreases with smoking.

There is evidence of the development of hepatitis when combined with furadonin.

It is possible to reduce the antispasmodic activity of papaverine hydrochloride under the influence of morphine.

Phentolamine potentiates the effect of papaverine on the cavernous bodies of the penis when co-administered.

When combined with antidepressants, an increase in the hypotensive effect is possible.

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Andipal tablets can be used in combination with other drugs, but before combining them with other drugs, you should always consult your doctor. Taking pills reduces the need for analgesics.

Description of dosage form

White or white tablets with a faint yellow tint.

Andipal is an effective remedy for fighting high blood pressure. Its reception allows you to stop a headache that appears against a background of increased spasm of the muscles and peripheral vessels of the brain. The medicine refers to multicomponent drugs, since it contains several active components, each of which has its own therapeutic effect.

Andipal is a medicine with pronounced antispasmodic, sedative, vasospastic and analgesic properties. It is used as symptomatic therapy for elevated spasms of cerebral vessels. Taking the drug allows you to lower and normalize the level of blood pressure, improve blood circulation, reduce the risk of various complications.

The composition of the drug contains 4 active ingredients, as well as excipients.

  • Metamizole sodium (analgin 0.25 mg) – relieves pain, relieves inflammation.
  • Dibazol 0.02 mg – reduces blood pressure, but has a short-term effect.
  • Papaverine hydrochloride 0.02 mg – relieves cramps, reduces blood pressure.
  • Phenobarbital 0.02 mg – calms, has an antispasmodic effect.

Other components of the drug act as excipients that do not have a significant effect on the body.

Feature of application

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Do not exceed the recommended dose of the drug.

Since metamizole sodium salt has anti-inflammatory and analgesic properties, it can mask the signs of infection, the symptoms of noncommunicable diseases and complications with pain, and may complicate their diagnosis.

When using the drug should refrain from drinking alcoholic beverages. The drug should be used with caution in patients:

  • existing allergic diseases (including hay fever) or with a previous history of these diseases – the risk of allergic reactions increases;
  • with inflammatory bowel diseases, including ulcerative colitis and Crohn’s disease;
  • with cardiovascular failure
  • with the simultaneous use of cytostatic drugs (only under the supervision of a physician).

Patients should be warned before starting treatment, if there is unmotivated chills, fever, sore throat, difficulty swallowing, bleeding gums, blanching of the skin, asthenia, with the development of vaginitis or proctitis, the drug should be stopped immediately. Also, the drug should be discontinued at the first rash on the skin and mucous membranes. If these symptoms appear, consult a doctor immediately.

Regular long-term use of the drug is not recommended due to the myelotoxicity of metamizole sodium salt; in case of prolonged use (more than 7 days), it is necessary to control the picture of peripheral blood (leukocyte formula).

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During the treatment period, urine staining in red is possible (due to the release of the metabolite), which does not have clinical significance.

With caution, weakened patients, with a decrease in intestinal motility. When taking the drug, the development of orthostatic hypotension is possible.

If symptoms of liver dysfunction appear, including gastrointestinal upsets, jaundice, eosinophils and an increase in the level of liver enzymes, you must stop taking the drug.

You should inform your doctor about the following symptoms: flushing, sweating, headache, fatigue, jaundice, skin rash, nausea, stomach discomfort, constipation.

Smoking worsens the effectiveness of the drug.

While taking the drug should abandon the use of alcohol and drugs that depress the central nervous system.

Pharmacodynamics

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Andipal, as an antispasmodic, is used for spasms of peripheral vessels and cerebral vessels. Reducing OPSS, acting on arterioles, the drug reduces blood pressure, improves collateral circulation. The combination of myotropic antispasmodics (dibazole and papaverine hydrochloride) with analgin enhances the analgesic effect of the latter in case of headache, migraine. The presence of phenobarbital in the drug contributes to the manifestation of a sedative effect and enhances the action of other components.

The ability to influence the reaction rate when driving vehicles or other mechanisms

During treatment, you should avoid driving and working with mechanisms.

From the gastrointestinal tract: nausea, constipation, increased activity of hepatic transaminases, jaundice, hepatitis, discomfort in the stomach, dry mouth;

allergic reactions: possible manifestations of hypersensitivity reactions, including rashes on the skin and mucous membranes, hyperemia, conjunctivitis, itching, urticaria, dry cough, runny nose, shortness of breath, burning in the throat, facial flushing, angioedema, bronchospastic syndrome, anaphylactic, anaphylactic Stevens-Johnson syndrome, Lyell syndrome;

On the part of the blood system and lymphatic system: leukopenia, thrombocytopenia, granulocytopenia, anemia, eosinophilia, agranulocytosis

From the side of the kidneys and urinary system: oliguria, anuria, proteinuria, interstitial nephritis, urine staining in red;

from the cardiovascular system: AV block, ventricular extrasystole, decreased cardiac output, decreased blood pressure, weakness, numbness, tremor, loss of consciousness, palpitations, arrhythmias, pain in the heart, with prolonged use – deterioration in ECG, orthostatic hypotension ventricular fibrillation, asystole, ventricular flutter, collapse, apnea,

from the central nervous system: drowsiness, excessive sweating, dizziness, headache, feeling of heat, hot flashes, anorexia.

In the event of any adverse events, the patient should consult a doctor.

Dosing and Administration

Take orally after a meal with a little water.

Adults take 1 tablet 1-2 times a day.

The maximum daily dose is 2 tablets.

The course of treatment depends on the nature and course of the disease, the effect achieved, the nature of complex pharmacotherapy, but the duration of treatment should not exceed 3 days.

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Take Andipal tablets only as directed by your doctor. The drug is not intended for prolonged use. The treatment course generally does not exceed 5 to 7 days. To achieve a therapeutic effect, the drug can be prescribed in combination with other drugs, but only a doctor can prescribe them.

For adults

The dose of the drug is 1 tablet 2 to 3 times a day. If necessary, the doctor can reduce or increase the dose of the drug. In some cases, medication is prescribed only for symptomatic therapy, that is, when there are migraine attacks or blood pressure jumps.

For children

The drug is not used in pediatrics.

Inside. Adults – 1-2 tablets. 2-3 times a day. The course of treatment is 7-10 days.

If treatment is ineffective, the drug should be replaced or combined with other drugs (to achieve a hypotensive effect).

Andipal is an antispasmodic, which, according to the opinions of doctors and doctors, has a mild hypotensive effect. To the question of how to take the drug, I want to focus the attention of fans of self-medication: the intake and dose of the medicine are selected by a specialist, according to the diagnosis and physiology. The official instructions from the manufacturer read as follows:

  • in the presence of high pressure, without the advice of a doctor, one tablet is allowed to relieve symptoms of characteristic hypertension;
  • with severe headache, it is recommended to take two tablets at intervals of one hour. In this case, the maximum allowable dose of the drug is five tablets;
  • with vegetovascular disorders – 1 pc. 2 times in 24 hours.

Overdose

Symptoms: hypothermia, marked decrease in blood pressure, arrhythmia, tachycardia, partial or complete blockade, excessive sweating, headache, feeling hot, dizziness, dysphagia, delirium, the development of acute agranulocytosis, acute renal or hepatic failure, respiratory muscle paralysis, decreased perfusion tissues, anxiety, lethargy, visual impairment, dizziness, ataxia, nystagmus, diplopia, central nervous system depression, collapse, coma, cyanosis, metabolic acidosis, hyperventilation, hyp erglycemia, hyperkalemia, oliguria, constipation, gastrointestinal tract, nausea, vomiting, rash, moderate dyspnea, tinnitus, drowsiness, redness of the skin.

With prolonged use in high doses: impaired liver function, neutropenia, hemorrhagic syndrome, cramps and impaired consciousness are possible.

Treatment. Gastric lavage, intake of sorbents, saline laxatives, forced diuresis. If seizures occur, consult a doctor.

Cases of overdose are not so common, but nevertheless, with an increase in the dose of the drug, nausea, confusion, vomiting, hypotension, convulsions and other symptoms requiring medical intervention may appear.

Symptoms: with an overdose, severe drowsiness, dizziness, collaptoid state occur.

Treatment: first aid – gastric lavage, intake of activated charcoal. Symptomatic Therapy

special instructions

  • Tablets are recommended for severe headaches and a slight increase in blood pressure.
  • Reception of tablets cannot exceed 7 – 10 days.
  • Andipal is forbidden to be taken on an empty stomach.
  • Drink the tablets with water.
  • The daily dose of the drug should not exceed 4 tablets.
  • It is forbidden to combine the medicine with other drugs that have anti-inflammatory effects.
  • Use the medicine with caution, since it has a number of contraindications.

Reviews of doctors about the medicine Andipal are not bad enough, but still the drug is intended for symptomatic therapy. It can not be used for a long time, nor can it be combined with other means of a similar therapeutic effect.

Caution should be exercised when working with mechanisms.

With prolonged use, it is necessary to control the blood picture.

Andipal should be prescribed with caution to people who are engaged in activities with an increased concentration of attention and are associated with a quick reaction. Its phenobarbital is addictive.

Andipal is not recommended for women who are expecting a baby and nursing mothers. In the absence of an alternative medicine, the newborn is transferred to artificial feeding. This is due to the action of the constituent component – phenobarbital. Even a small dose of this substance can provoke a delay in the development of the fetal brain, and the syndrome of the onset of cerebral palsy increases tenfold.

Kids and teens

Taking the drug is not recommended for children. Admission Andipal can be assigned to a teenager after he reaches the age of 14. In exceptional cases, Andipal is used under the supervision of the attending physician, in accordance with the prescribed dosage, if no alternative is found.

Joint reception of Andipal with any drink containing alcohol is strictly prohibited! The components that make up the drug enhance the effect of ethyl alcohol on the body, which is fraught with unpredictable consequences.

With prolonged (more than 7 days) use, it is necessary to control the picture of peripheral blood and the functional state of the liver. Alcohol is prohibited.

Medical instruction

Andipal must be taken orally. The dosage for adults is 1 tablet 2-3 times a day. The course of treatment should not exceed 1 week to 10 days.

Important! It is recommended to take the drug as directed and under the supervision of a doctor.

In the event that the use of the drug does not have the necessary therapeutic effect, it is necessary to consult a doctor and choose a different treatment regimen. In some cases, it may be necessary to combine the Andipal preparation with other drugs to achieve a pronounced therapeutic effect.

Andipal
Instructions for medical use – RU No. LSR-007455/10

Last Modified Date: 21.04.2017//

Dosage form

Composition

Composition per tablet

  • Bendazole hydrochloride (dibazole) – 0,02 g
  • Metamizole sodium monohydrate (analgin) – 0,25 g
  • Papaverine hydrochloride – 0,02 g
  • Phenobarbital – 0,02 g
  • potato starch – 0,0489 g
  • talcum powder – 0,0074 g
  • stearic acid 0,0037 g

Description of dosage form

Tablets are white or white with a slightly yellowish tinge of color, a flat-cylindrical shape with a chamfer and a risk.

Pharmacological group

Combined analgesic (non-narcotic analgesic, antispasmodic, barbiturate)

Pharmacological (immunobiological) properties

The combined drug has a vasodilating, analgesic, antispasmodic and sedative effect.

Andipal, as an antispasmodic, is used for spasms of peripheral vessels and cerebral vessels.

Reducing the total peripheral resistance, acting on arterioles, the drug reduces blood pressure, improves collateral circulation. The combination of myotropic antispasmodics (bendazole and papaverine) with metamizole sodium enhances the analgesic effect of the latter in case of headache, migraine. The presence of phenobarbital in the drug contributes to the manifestation of a sedative effect and enhances the action of other components.

Pharmacokinetics

Metamizole Sodium: It is well and quickly absorbed in the gastrointestinal tract. It is hydrolyzed in the intestinal wall with the formation of an active metabolite, unchanged metamizole sodium in the blood is absent (only after intravenous administration is an insignificant concentration found in plasma). The relationship of the active metabolite with proteins is 50-60%. It is metabolized in the liver, excreted by the kidneys. In therapeutic doses, it passes into breast milk.

Papaverine: Absorption depends on the dosage form. Bioavailability on average – 54%. Communication with plasma proteins – 90%. It is well distributed, penetrates histohematological barriers. Metabolized in the liver. T½ – 0,5-2 hours (can be extended up to 24 hours). It is excreted by the kidneys in the form of metabolites. It is completely removed from the blood during hemodialysis.

Phenobarbital: When administered, phenobarbital is completely, but relatively slowly absorbed. The maximum concentration in the blood is observed 1 to 2 hours after administration. About 50% is bound by plasma proteins. The drug is evenly distributed in different organs and tissues; lower concentrations are found in brain tissue. The half-life in adults is 2-4 days. It is secreted from the body slowly, which creates the prerequisites for cumulation. Metabolized by microsomal liver enzymes. It is excreted by the kidneys in the form of inactive metabolites, 25-50% – unchanged.

Показания

Pain syndrome associated with spasm of peripheral arteries, smooth muscles of the gastrointestinal tract, cerebral vessels; arterial hypertension.

contraindications

Hypersensitivity, liver failure, chronic renal failure, glucose-6-phosphate dehydrogenase deficiency, blood diseases, tachyarrhythmia, severe angina pectoris, decompensated chronic heart failure, angle-closure glaucoma, prostate hyperplasia, intestinal obstruction, megacolon, pregnancy, children, pregnancy 8 years old, bronchial asthma triggered by the intake of acetylsalicylic acid, salicylates and other non-steroidal anti-inflammatory drugs arats.

Dosing and Administration

1-2 tablets 2-3 times a day. The course of treatment is 7-10 days.

Side effects

Drowsiness, decreased rate of psychomotor reactions, decreased blood pressure, impaired liver/kidney function. Sometimes nausea, constipation, allergic reactions (up to anaphylactic shock) occur. With prolonged use of the drug, a depressing effect on the blood is possible due to the presence of metamizole sodium (leuko penis, caustic agra nulocytosis – thrombocytopenia) The presence of phenobarbital can have a sedative effect, ataxia and depression can sometimes occur (especially in elderly and debilitated patients).

Overdose

In case of an overdose, severe drowsiness, dizziness, collaptoid state occur.

First aid: gastric lavage, intake of activated carbon. Symptomatic Therapy

Interaction

Pharmacodynamic: combination with nitrates (including nitroglycerin, isosorbide dinitrate), slow calcium channel blockers (including nifedipine), amiodarone, beta-adrenergic blocking agents (including propranolol, metopropol, oxprenolol, talinololumium), ganglio-azole blocker bromide), diuretics (including furosemide, hydrochlorothiazide), myotropic antispasmodics (including dipyridamole, aminophylline) enhances the hypotensive effect of Andipal.

The combined use of alpha-adrenergic agonists direct (including epinephrine, norepinephrine) and indirect (ephedrine) type of action, N-cholinomimetics (including nicotine, acetylcholine), analeptics (including camphor, sulfocamphocaine [procaine sulfocamphoric acid], niketamide, bemegrid, lobelia, cytisine), tonic agents (including ginseng root, eleutherococcus of prickly rhizomes and root extract, rhodiola extract) and Andipal reduces the hypotensive effect of the latter.

Mutual increase in the risk of side effects while using narcotic analgesics.

Pharmacokinetic: the combination of the use of adsorbents (activated carbon), astringents and enveloping agents reduces the absorption of the drug in the gastrointestinal tract.

special instructions

With prolonged (more than 7 days) use, it is necessary to control the picture of peripheral blood and the functional state of the liver.

During the treatment period, it is necessary to refrain from engaging in potentially dangerous activities that require a high concentration of attention and speed of psychomotor reactions.

Form of issue

On 10 tablets in a blister strip packaging from a film of polyvinyl chloride and foil of aluminum printed varnished or packaging paper with a polymer coating.

10 tablets in a contour bezjacheykovy packaging made of polymer coated paper.

For 10,20,30,40,50,60,100 tablets in a polymer jar.

Each jar or 1, 2, 3, 4, 5 blister strip packagings, together with instructions for use, are placed in a pack.

Banks of polymer or contour packaging with an equal number of instructions for use are placed in a group package.

Storage conditions

In a dry, dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life

2 years 6 months Do not use after the expiration date indicated on the package.

Conditions of leave from pharmacies

Andipal – instructions for medical use – RU №

LS-000733 from 2019-01-21

Andipal – instructions for medical use – RU №

ЛСР-006417/08 от 2013-08-14

Andipal – instructions for medical use – RU №

LP-003892 from 2016-10-07

Andipal – instructions for medical use – RU №

ЛСР-007455/10 от 2012-12-17

Andipal – instructions for medical use – RU №

ЛСР-002220/07 от 2007-08-15

Andipal – instructions for medical use – RU №

ЛСР-006417/08 от 2013-08-14

Andipal – instructions for medical use – RU №

LS-002641 from 2013-10-15

Andipal – instructions for medical use – RU №

ЛСР-002455/08 от 2014-06-27

Andipal – instructions for medical use – RU №

LS-002641 from 2006-12-29

Andipal – instructions for medical use – RU №

Tatyana Jakowenko

Editor-in-chief of the Detonic online magazine, cardiologist Yakovenko-Plahotnaya Tatyana. Author of more than 950 scientific articles, including in foreign medical journals. He has been working as a cardiologist in a clinical hospital for over 12 years. He owns modern methods of diagnosis and treatment of cardiovascular diseases and implements them in his professional activities. For example, it uses methods of resuscitation of the heart, decoding of ECG, functional tests, cyclic ergometry and knows echocardiography very well.

For 10 years, she has been an active participant in numerous medical symposia and workshops for doctors - families, therapists and cardiologists. He has many publications on a healthy lifestyle, diagnosis and treatment of heart and vascular diseases.

He regularly monitors new publications of European and American cardiology journals, writes scientific articles, prepares reports at scientific conferences and participates in European cardiology congresses.

Detonic