Ceftriaxone and novocaine – can it be taken simultaneously (compatibility)

Like most antibiotics, the active substance of the drug Ceftriaxone is not supplied in the form of a ready-made solution, but in the form of a crystalline powder of a slightly yellowish or white color. It is placed in transparent glass bottles under a rubberized stopper and an aluminum cap.

This is done for reasons of preserving the activity of the active substance – ceftriaxone. The powder is easily soluble in water (the dissolution time should be no more than 2 minutes according to the standard), very weakly in ethanol.

The resulting substance varies in color from light yellow to amber, it depends on the shelf life, type of solvent used and the concentration of the drug.

The drug is dispensed from pharmacies in vials of 0,25, 0,5, 1 or 2 grams in the form of sterile ceftriaxone sodium salt. The most common dosage is 1 g.

The instructions for medical use of the drug say that this medicine can be administered exclusively parenterally: intravenously or intramuscularly. Once in the body using one of these methods, the drug is completely absorbed, bioavailability is 100%.

The powder is allowed to be diluted with water for injection or with anesthetics (Lidocaine, Novocaine). These are common antibiotic dilution fluids. The choice of solution depends on the method of drug intake into the body.

If the doctor writes a prescription for ceftriaxone for intramuscular administration, then it is permissible to use any of these solutions. If the medicine must be administered intravenously, then the only approved liquid is water for injection. Lidocaine and Novocaine are strictly prohibited for this.

The preparation procedure is simple. Knowing the precautions and important aspects in the technology of dilution and use of the antibiotic, you can correctly prepare the composition of the desired concentration.

The good news is that both Ceftriaxone and the sterile diluent for it are easy to buy in a regular pharmacy with a doctor’s prescription.

Almost all patients note that Ceftriaxone injections are extremely unpleasant and painful, especially when dissolved in water for injection. Moreover, negative feelings will accompany both the process of drug administration itself and will persist for some time after the manipulation. Therefore, it is much better to dilute the drug with painkillers to facilitate the tolerance of the injection.

Ceftriaxone’s painful injection

One of the permitted solvents is a 0,5% Novocaine solution. You can also use 1 or 2% solution of lidocaine. Doctors still disagree about the best basis for the drug.

It should be noted that, according to some scientific data, Novocaine can slightly reduce the severity of Ceftriaxone, and increase the risk of anaphylactic shock in a patient.

But nevertheless, it relieves pain with the introduction quite well in comparison with ordinary water for injection.

Before the introduction of a full dose of the drug, it is worth making a test for the tolerance of Ceftriaxone and the anesthetic used. To do this, you need to make a couple of small scratches on the skin of the inner part of the forearm and apply a few drops of Ceftriaxone and Novocaine on them separately.

If a person has a high sensitivity to one or both components, then the skin at the place of application of the preparations will turn red strongly after 5-10 minutes, swelling and local itching may occur.

If all is well and there is no allergic reaction to any of the drugs in solution, then proceed to the procedure.

  • The substance is prepared immediately before use.
  • The required amount of the drug in powder and a sufficient amount of solvent are taken.
  • During the injection, the condition must be met: you can not enter more than 1 g of the antibiotic in one buttock.
  • The drug is injected deeply intramuscularly (almost the entire length of a 5 ml syringe needle) into the upper outer quadrant of the buttock.
  • Ceftriaxone pours very slowly during the injection.
  • The ready-made solution is used exclusively for a single injection, if only part of the contents of the vial is used up for injection, the remainder is always discarded.
  • The solution of the drug remains stable in physical and chemical properties for 6 hours at room temperature, after which time the drug must be disposed of.

The quantitative ratio of Ceftriaxone and Novocaine powder will depend on the concentration of the final solution, according to the recipe.

Dosage is determined by the doctor

For intramuscular administration, 0,25, 0,5 or 1 g of antibiotic in the prepared solution can be used. The dosage is determined by the attending physician. In this case, the doctor takes into account the following factors: the type and severity of the pathology, the age of the patient, the duration of the disease.

To get 1 g of the finished product, you need to add 1 ml of 5% Novocaine from the ampoule to a bottle with 0,5 g of Ceftriaxone powder. If the volume of the anesthetic is reduced, there is a risk that the antibiotic cannot completely dissolve and large particles of the drug get stuck in the lumen of the needle.

Necessary steps to obtain a solution:

  • First you need to prepare everything you need: Ceftriaxone lyophilisate in a 1 g or 1000 mg glass vial, ampoules with 0,5% Novocaine solution (1 ampoule is 5 ml), 5 ml syringe, sterile beads and gloves, medical alcohol.
  • Wash hands with soap, dry, put on medical gloves.
  • Open the syringe package, break off the glass top of the ampoule with Novocaine, bend the aluminum “window” in the central part of the cap of the vial with the antibiotic.
  • Wipe the rubberized stopper of the Ceftriaxone vial with an alcohol cotton ball.
  • Dispense 5 ml of Novocain into a syringe.
  • Pass the needle through the cork and slowly pour the anesthetic solution into the bottles.
  • Shake the bottle vigorously enough until the powder disappears completely.
  • Put the right amount of ready-made solution into the syringe.

Thus, a solution with a Ceftriaxone concentration of 1 g or 1000 mg will be obtained. To get other doses of the antibiotic, you need to follow the same steps, but take different proportions of the drugs:

  • to prepare 0,5 g or 500 mg of the substance, 0,5 g of powder and 5 ml of Novocaine are taken;
  • to obtain 0,25 g or 250 mg, 0,5 g of powder and 10 ml of Novocaine are necessary, then half (5 ml) of the resulting solution is drawn into the syringe.

For intramuscular use in children, the drug is most often diluted with sterile water for injection, since the use of Ceftriaxone with Novocaine can lead to the development of a pronounced anaphylactic reaction. The limited use of pain medication in pediatrics requires an extremely slow and careful administration of an antibiotic to minimize pain during the procedure.

Ceftriaxone dilution table for intramuscular injection

Ceftriaxone concentration in a bottle, mgThe required dosage of the finished solution, mgThe amount of 0,5% Novocaine, mlDial in syringe, ml

In order to combat bacterial infections, doctors often prescribe the antibacterial drug Ceftriaxone.

How to dilute it correctly and in which solutions depends on the presence of allergic reactions in humans and on the route of administration of the drug. All this is determined by the doctor. It is important to follow his recommendations exactly.

If the drug is prescribed as an intramuscular injection, then the pain of the injection can be reduced using an anesthetic, in particular Novocaine.

How to breed Ceftriaxone Novocaine Link to main publication

Is it possible to breed ceftriaxone with Novocaine? Since ceftriaxone is available only in dry form as a lyophilized powder, it must be dissolved before administration according to the instructions.

According to the doctor’s decision:

  • Ceftriaxone can be bred with Novocain;
  • either lidocaine;
  • or use distilled water.

The condition of the patient’s body, as well as the method of drug administration, affects the choice of solvent.

Real Ceftriaxone is sold only in powder form. But this antibiotic is intended for intramuscular or intravenous administration. Injections require liquid solutions. Ceftriaxone can be diluted with both distilled water and anesthetics.

Ceftriaxone can be diluted with distilled water. But in this case, when administered intravenously or intramuscularly, the patient experiences severe pain. Therefore, Novocaine or Lidocaine is used as a solvent. The latter is more preferable because it is less allergic.

Which of the analgesics to use as a solvent, the doctor chooses, but depends:

  1. From the place where the doctor recommended administering the medicine.
  2. From the tolerance of one of the anesthetics. Therefore, before the appointment of injections, a test for tolerance of the anesthetic substance is made.

Is it possible to breed ceftriaxone with Novocaine? You can breed if there are no contraindications to the use of analgesics. Recommendations for the use of solvent are given by the attending physician. You must understand that both drugs can trigger a severe allergy.

Initially, you need to study the instructions, then you can start preparing the medicine. The use of diluted medication should be only in the amount recommended by the doctor.

Before taking Procaine as a solvent, you need to find out if there are any contraindications to the use of Novocaine. If the patient has an increased susceptibility to Novocaine, then its use can provoke anaphylactic shock.

Therefore, 0,5 ml of a liquid is injected into the muscle. If after half an hour there are no changes, then you can enter the rest of the dose, only in another buttock.

Preparing solutions is required immediately before use.

  • an antibiotic in a dissolved state retains its stability for only six hours;
  • a stale solution may enhance pain. Freshly prepared liquid is used once.

How to breed Ceftriaxone Novocaine, what is needed for this?

  1. To prepare a solution on Novocaine, it is required to draw 1 ml per 5 g of Ceftriaxone into a Novocaine syringe. With a smaller amount, the powder content of the vial will not completely dissolve. The syringe, or rather, the needle is clogged with undissolved lumps.
  2. Then the syringe with the solvent is introduced into the bottle with the powder. Shake the contents well without taking out the corner. The diluted preparation is ready for use.
  3. After dilution in the syringe, as much liquid medicine is collected as required. The remainder is thrown away.

Side effects of ceftriaxone

Bactericidal. The drug of the third generation from the group of antibiotics “Cephalosporins”.

Side effects of the drug are manifested in the form of:

  • hypersensitivity reactions – eosinophilia, fever, pruritus, urticaria, edema, skin rash, erythema multiforme (in some cases malignant), serum sickness, anaphylactic shock, chills;
  • headache and dizziness;
  • oliguria;
  • digestive organs dysfunctions (nausea, vomiting, flatulence, taste disorder, stomatitis, diarrhea, glossitis, formation of sludge in the gallbladder and pseudo-cholelithiasis, pseudomembranous enterocolitis, dysbiosis, candidomycosis and other superinfection);
  • hematopoiesis disorders (anemia, including hemolytic; lympho-, leuko-, neutro-, thrombocyte-, granulocytopenia; thrombo- and leukocytosis, hematuria, basophilia, nosebleeds).

If the medicine is administered intravenously, inflammation of the venous wall is possible, as well as soreness along the vein. The introduction of the drug into the muscle is accompanied by pain at the injection site.

Ceftriaxone (injections and IV infusion) may also affect laboratory performance. The patient’s prothrombin time decreases (or increases), the activity of alkaline phosphatase and liver transaminases increases, as well as the concentration of urea, hypercreatininemia, hyperbilirubinemia, and glucosuria develop.

Reviews of the side effects of Ceftriaxone suggest that with i / m administration of the drug, almost 100% of patients complain of severe pain in the injection, some note muscle pain, dizziness, chills, weakness, itching and rash.

The injections are most easily tolerated if the powder is diluted with painkillers. In this case, it is necessary to make a test both for the drug itself and for pain medication.

In one volume, it is pharmaceutically incompatible with other antimicrobial agents.

Suppressing the intestinal microflora, prevents the formation of vitamin K. In the body, for this reason, the use of the drug in combination with agents that reduce platelet aggregation (sulfinpyrazone, NSAIDs) can cause bleeding.

The same feature of Ceftriaxone enhances the action of anticoagulants when used together.

In combination with loop diuretics, the risk of developing nephrotoxicity is increased.

Ceftriaxone during Pregnancy and Breastfeeding

How to breed ceftriaxone before the upcoming injection? In some patients, administration of an antibiotic that is dissolved in lidocaine may cause an undesirable immune response.

In order not to harm the patient, you should first check how the body reacts to Ceftriaxone solution. For this, two small scratches are made on the inside of the forearm. One of them is treated with a small amount of antibiotic, the other with an anesthetic. Results will need to wait approximately 5-10 minutes. If the test area of ​​the skin has retained its natural color, then an injection is allowed.

The attached instructions for use with the antibiotic recommends dissolving Ceftriaxone 1% Lidocaine.

  • a syringe with a capacity of 5 cubes is taken and 3,5 ml of a solution of lidocaine is collected;
  • on the bottle containing the powder, you should bend the aluminum cap;
  • rubber cork is treated with cotton wool soaked in alcohol;
  • a needle is inserted into the cork and the solution is slowly introduced;
  • to dilate Ceftriaxone, the bottle must be shaken well.

When diluting a powdery substance, there should be no problems, since it dissolves quite easily. Doctors warn: if you dilute the medicine and there appears clouding or any foreign impurities, you should refrain from using the solution.

Unfortunately, it is not always possible to get 1% lidocaine. Typically, 2% anesthetic is sold in pharmacies. In this case, in order to achieve the best effect, it should be diluted with a small amount of water.

  1. Prepare one ampoule of anesthetic and distilled water, which will be mixed in one syringe.
  2. First you need to collect 2 ml of lidocaine, and then the liquid in the same amount.
  3. To make a solution, the contents of the syringe are shaken vigorously.
  4. Now the required concentration of anesthetic is injected into the bottle where the powder is located.

As stated in the instructions, if you need to dilute Ceftriaxone in an amount of 0,5 g, you need to prepare 1 ml of lidocaine and water.

A day for adult patients is allowed to use no more than two grams of the diluted substance, while a maximum of 1 g of the drug can be injected into one buttock.

You should remember some rules when Ceftriaxone is indicated to be administered intravenously. Anesthetic agents will not be used for this procedure. Instead, the antibiotic is diluted in water or with sodium chloride.

It is advisable that a qualified nurse bred and injected the medicine into a vein. The procedure should be carried out carefully and slowly. If, according to the doctor’s prescription, you need to enter a dose that exceeds 1 g, the injection is replaced by a dropper. To prepare the solution, you will need sodium chloride in an amount of 100 ml.

The diluted mixture should be used immediately. If you enter the solutions immediately after preparation, you can get the desired results much faster.

Is it possible to use ceftriaxone in childhood and how to do it right? Ceftriaxone intramuscularly can be prescribed from birth.

  1. Babies up to 2 weeks are prescribed the introduction of 20-50 mg of the drug per kilogram of weight.
  2. Starting from the first month of life and up to 12 years, it is shown to take from 20 to 75 mg of the substance per 1 kg of body weight.

If you need to use a diluted preparation in a dose that is more than the established norm, a dropper is used instead of an injection. Children from 12 years of age are prescribed the same dosages as adults.

Despite the accepted norms of the drug, when composing a treatment course, the dosage is selected individually. The specialist must take into account the clinical manifestations of the disease, its severity and characteristics of the child’s body.

For women in position and lactating, treatment with diluted ceftriaxone is not recommended. However, an injection can be given to pregnant women if the benefits of the medicine exceed the potential harm to the fetus. During lactation, the injection solution is also prescribed only in extreme cases, while the baby is transferred to artificial mixtures.

Signs of an overdose are convulsions and central nervous system agitation. Peritoneal dialysis and hemodialysis are ineffective in decreasing Ceftriaxone concentration. The medicine has no antidote.

The drug is contraindicated in the first trimester of pregnancy. If necessary, appoint a nursing woman, the child should be transferred to the mixture.

Reviews about Ceftriaxone during pregnancy confirm that the drug really is a very powerful and very effective antibacterial agent that can not only cure the underlying disease, but also prevent the development of its complications.

Given that the drug (like other antibiotics) has side effects, it is prescribed only in cases where the potential complications of the disease can do more harm than the use of the drug (in particular, with infections of the urogenital tract, which pregnant women are very susceptible to).

Pharmacodynamics and pharmacokinetics

A universal antibacterial agent, the mechanism of action of which is due to the ability to inhibit the synthesis of bacterial cell walls. The drug exhibits great resistance to most β-lactamases Gram () and Gram (-) microorganisms.

  • Gram () Aerobic – St. aureus (including with respect to penicillinase producing strains) and Epidermidis, Streptococcus (pneumoniae, pyogenes, viridans group);
  • A gram of (-) aerobes – Enterobacter aerogenes and cloacae, Acinetobacter calcoaceticus, Haemophilus influenzae (including against penicillinase producing strains) and parainfluenzae, Borrelia burgdorferi, Klebsiella spp. (including pneumoniae), Escherichia coli, Moraxella catarrhalis and diplococci of the genus Neisseria (including penicillinase producing strains), Morganella morganii, vulgar protea and protea mirabilis, Neisseria meningitidis, Serratia spp. , some strains of Pseudomonas aeruginosa;
  • Anaerobes – Clostridium spp. (exception – Clostridium difficile), Bacteroides fragilis, Peptostreptococcus spp. .

In vitro (clinical significance remains unknown), activity against strains of the following bacteria is noted: Citrobacter diversus and freundii, Salmonella spp. (including in relation to Salmonella typhi), Providencia spp. (including in relation to Providencia rettgeri), Shigella spp .; Bacteroides bivius, Streptococcus agalactiae, Bacteroides melaninogenicus.

Resistant to methicillin Staphylococcus, many Enterococcus strains (including Str. Faecalis) and group D Streptococcus are resistant to cephalosporin antibiotics (including ceftriaxone).

  • bioavailability – 100%;
  • T Cmax with the introduction of Ceftriaxone iv – at the end of the infusion, with the introduction of intramuscularly – 2-3 hours;
  • communication with plasma proteins – from 83 to 96%;
  • T1 / 2 for i / m administration – from 5,8 to 8,7 hours, for iv administration – from 4,3 to 15,7 hours (depending on the disease, patient’s age and condition of his kidneys).

In adults, the concentration of ceftriaxone in cerebrospinal fluid with the introduction of 50 mg / kg after 2-24 hours is many times higher than the MPC (minimum inhibitory concentration) for the most common pathogens of meningococcal infection. The drug penetrates well into the cerebrospinal fluid with inflammation of the meninges.

Ceftriaxone is excreted unchanged:

  • kidneys – by 33-67% (in newborn babies this indicator is at the level of 70%);
  • with bile into the intestines (where the drug is inactivated) – by 40-50%.

Indications Ceftriaxone

The annotation indicates that the indications for the use of Ceftriaxone are infections caused by bacteria sensitive to the drug. Intravenous infusions and injections are prescribed for the treatment of:

  • infections of the abdominal cavity (including with empyema of the gallbladder, angiocholitis, peritonitis), ENT organs and respiratory tract (empyema of the pleura, pneumonia, bronchitis, lung abscess, etc.), bone and joint tissue, soft tissues and skin, urogenital tract (including pyelonephritis, pyelitis, prostatitis, cystitis, epididymitis);
  • epiglottitis;
  • infected burns / wounds;
  • infectious lesions of the maxillofacial region;
  • bacterial septicemia;
  • sepsis;
  • bacterial endocarditis;
  • bacterial meningitis;
  • syphilis;
  • chancroid;
  • tick-borne borreliosis (Lyme disease);
  • uncomplicated gonorrhea (including in cases where the disease is caused by microorganisms that secrete penicillinase);
  • salmonellosis / salmonella carriage;
  • typhoid fever.

The drug is also used for perioperative prophylaxis and for the treatment of immunocompromised patients.

Despite the fact that with various forms of syphilis, penicillin is the drug of choice, its effectiveness in some cases may be limited.

The use of cephalosporin antibiotics is resorted to as a backup option for intolerance to penicillin group preparations.

Valuable properties of the drug are:

  • the presence in its composition of chemicals that have the ability to suppress the formation of cell membranes and mucopeptide synthesis in bacterial cell walls;
  • the ability to quickly penetrate into the organs, fluids and tissues of the body and, in particular, into the cerebrospinal fluid, which undergoes many specific changes in patients with syphilis;
  • the possibility of use for the treatment of pregnant women.

The drug is most effective in cases where the causative agent of the disease is Treponema pallidum, since Ceftriaxone’s distinctive feature is its high treponemocidal activity. The positive effect is especially pronounced with the / m administration of the drug.

Treatment of syphilis with the use of the drug gives good results not only in the early stages of the development of the disease, but also in advanced cases: with neurosyphilis, as well as with secondary and latent syphilis.

Since T1 / 2 of Ceftriaxone is approximately 8 hours, the drug can equally well be used in both inpatient and outpatient treatment regimens. The drug is enough to enter the patient 1 time per day.

For preventive treatment, the drug is administered for 5 days, with primary syphilis – a 10-day course, early latent and secondary syphilis are treated in 3 weeks.

With non-started forms of neurosyphilis, the patient is administered once per day for 20-1 g of Ceftriaxone 2-1 g; in the later stages of the disease, the drug is administered 3 g / day. for 14 weeks, after which they maintain an interval of 10 days and for days they are treated with the same dosage.

In acute generalized meningitis and syphilitic meningoencephalitis, the dose is increased to 5 g / day.

Despite the fact that the antibiotic is effective for various lesions of the nasopharynx (including tonsillitis and sinusitis), it is usually rarely used as the drug of choice, especially in pediatrics.

With angina, the medicine can be administered through a dropper into a vein or in the form of conventional injections into the muscle. However, in the vast majority of cases, the patient is prescribed intramuscular injection. The solution is prepared immediately before use. The finished mixture at room temperature remains stable for 6 hours after preparation.

Ceftriaxone is prescribed for children with angina in exceptional cases, when acute angina is complicated by severe suppuration and the inflammatory process.

The appropriate dosage is determined by your doctor.

During pregnancy, the drug is prescribed in cases where penicillin group antibiotics are not effective. Although the drug crosses the placental barrier, it does not significantly affect the health and development of the fetus.

With sinusitis, antibacterial agents are first-line drugs. Penetrating completely into the blood, Ceftriaxone lingers in the focus of inflammation in the right concentrations.

As a rule, the medicine is prescribed in combination with mucolytics, vasoconstrictors, etc.

How to inject the drug with sinusitis? Typically, a patient with Ceftriaxone is prescribed to inject 0,5-1 g into the muscle twice a day. Before injection, the powder is mixed with lidocaine (it is preferable to use a one percent solution) or water d / u.

Treatment lasts at least 1 week.

Ceftriaxone is not prescribed with known hypersensitivity to cephalosporin antibiotics or auxiliary components of the drug.

  • the neonatal period in the presence of hyperbilirubinemia in the child;
  • prematurity;
  • renal / liver failure;
  • enteritis, ULC or colitis associated with the use of antibacterial agents;
  • pregnancy;
  • lactation.

The manufacturer’s instructions and the Vidal manual indicate that the drug can be injected into a vein or muscle.

Dosage for adults and for children over 12 years old is 1-2 g / day. The antibiotic is administered once or once every 1 hours in half dose.

In especially serious cases, as well as if the infection is provoked by a pathogen that is moderately sensitive to Ceftriaxone, the dose is increased to 4 g / day.

With gonorrhea, a single injection of 250 mg of the drug into the muscle is recommended.

For prophylactic purposes, before an infected or presumably infected operation, depending on the degree of danger of infectious complications, a patient should administer 0,5-1,5 g of Ceftriaxone once 1-2 hours before surgery.

For children of the first 2 weeks of life, the medicine is administered 1 r. / Day. The dose is calculated according to the formula 20-50 mg / kg / day. The highest dose is 50 mg / kg (which is associated with the underdevelopment of the enzyme system).

The optimal dosage for children under 12 years of age (including infants) is also selected depending on the weight. The daily dose varies from 20 to 75 mg / kg. For children whose weight is more than 50 kg, Ceftriaxone is prescribed in the same dose as adults.

A dose exceeding 50 mg / kg should be administered as an intravenous infusion lasting at least 30 minutes.

With bacterial meningitis, treatment begins with a single injection of 100 mg / kg / day. The highest dose is 4 g. As soon as the pathogen is isolated and its sensitivity to the drug is determined, the dose is reduced.

Reviews of the drug (in particular, its use in children) allow us to conclude that the drug is very effective and affordable, but its significant drawback is severe pain at the injection site. As for the side effects, according to the patients themselves, no more than using any other antibiotic.

The duration of treatment depends on what pathogenic microflora is caused by the disease, as well as on the characteristics of the clinical picture. If the causative agent is Gram (-) diplococcus of the genus Neisseria, the best results can be achieved in 4 days, if sensitive to the drug enterobacteria, in 10-14 days.

For dilution of the antibiotic, a solution of lidocaine (1 or 2%) or water for injection (d / i) is used.

When using water d / and it should be borne in mind that the / m injection of the drug is very painful, so if the solvent is water, unpleasant sensations will occur both during the injection and some time after it.

Water for diluting the powder is usually taken in cases where the use of lidocaine is not possible because the patient has an allergy to it.

The best option is a one percent solution of lidocaine. Water d / and it is better to use as an adjuvant, with a dilution of the drug Lidocaine 2%.

Novocaine when used to dilute the drug reduces the activity of the antibiotic, while increasing the likelihood of anaphylactic shock in the patient.

Based on the feedback from the patients themselves, it is noted that Lidocaine better than Novocaine relieves pain when Ceftriaxone is administered.

In addition, the use of a not freshly prepared solution of Ceftriaxone with Novocaine enhances pain during the injection (the solution remains stable for 6 hours after preparation).

If Novocaine is still used as a solvent, it is taken in a volume of 1 ml per 5 g of the drug. If you take a smaller amount of Novocaine, the powder may not completely dissolve, and the syringe needle will become clogged with lumps of medicine.

For injection into the muscle, 0,5 g of the drug is dissolved in 2 ml of a 1% solution of lidocaine (the contents of one ampoule); 3,6 ml of solvent are taken per g of the preparation.

A dosage of 0,25 g is diluted in the same way as 0,5 g, that is, the contents of 1 ampoule of 1% lidocaine. After this, the finished solution is collected in different syringes, half the volume in each.

The medicine is injected deep into the gluteal muscle (not more than 1 g in each buttock).

Diluted Lidocaine is not intended for intravenous administration. It is allowed to enter strictly into the muscle.

For dilution, 1 g of the drug is taken in 1,8 ml of water d / and two percent lidocaine. To dilute 0,5 g of the drug, 1,8 ml of lidocaine with 1,8 ml of water d / i are also mixed, but only half of the resulting solution (1,8 ml) is used for dissolution. To dilute 0,25 g of the drug, 0,9 ml of a solvent prepared in a similar manner is taken.

The above method of intramuscular injections is practically not used in pediatric practice, since ceftriaxone with novocaine can cause severe anaphylactic shock in a child, and in combination with lidocaine it can contribute to the occurrence of a seizure in violation of the heart.

For this reason, the optimal solvent in the case of the use of the drug in children is ordinary water d / i. The inability to use pain medication in childhood requires even slower and more accurate administration of the drug to reduce pain during the injection.

For iv administration, 1 g of the drug is dissolved in 10 ml of distilled water (sterile). The drug is administered slowly over 2-4 minutes.

When carrying out infusion therapy, the drug is administered for at least half an hour. To prepare the solution, 2 g of the powder is diluted in 40 ml of a Ca-free solution: dextrose (5 or 10%), NaCl (0,9%), fructose (5%).

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Before using any medication, you must carefully read the instructions, since serious contraindications are not ruled out.

Contraindications and possible complications

  • excessive sensitivity to the components of the solution;
  • high levels of bilirubin;
  • heart failure;
  • myocardial infarction;
  • epileptic disorders;
  • nervous excitability;
  • hemodialysis course;
  • acute or chronic liver lesions;
  • problems with the kidneys and adrenal glands;
  • alcohol addiction;
  • pregnancy (especially in the first trimester);
  • breastfeeding.
  • persistent nausea;
  • gagging after eating;
  • acute manifestations of dysbiosis;
  • stomatitis with intense symptoms;
  • rashes;
  • angioedema;
  • excessive excitement;
  • anxiety
  • sleep disturbances;
  • sharp pains in the head;
  • dizziness after waking up;
  • acute conjunctivitis;
  • anaphylactic shock;
  • itchy genital discomfort;
  • candidiasis.

Taking into account the listed manifestations arising from injections, it is worth avoiding the use of a diluted antibiotic without consulting a doctor.

If the patient does not adhere to the prescribed dosages or begins to use a solution that has been stored for longer than expected, the appearance of dysbiosis is not excluded. The drug has the ability to inhibit the activity of microbes. With the illiterate use of the drug, along with pathogenic microorganisms, useful ones die.

  • pain in the abdomen;
  • frequent diarrhea;
  • nausea and vomiting.

Due to dysbiosis, fungal infection may develop.

  1. You should first read the instructions, which indicate how to breed Ceftriaxone and in what proportions.
  2. It is better to dilute the prescribed Ceftriaxone with lidocaine. If you take Novocaine, the antibacterial agent will be less effective, while serious complications, for example, anaphylactic shock, are not excluded.
  3. It is forbidden to mix Ceftriaxone with other antibiotic drugs, otherwise intense allergic manifestations should be expected.
  4. When diluted, the injection dose can be stored for no longer than 6 hours.
  5. Lidocaine, which is considered the best of anesthetics, is used only for intramuscular injection. To inject the powder intravenously, it is diluted in saline or in sterile water.
  6. The injection area is the upper part of the gluteal muscle. The dissolved antibiotic is administered gradually so as not to provoke severe pain.
  7. If intramuscular injection caused a negative reaction, you should immediately inform your doctor about what happened.

Treatment with antibiotics will only benefit if their use is approved by a specialist.

How to dilute Ceftriaxone antibiotic?

The price of Ceftriaxone injections varies depending on which company it is produced, as well as on the number of ampoules in each package and the concentration of the active substance in the bottle.

The price of Ceftriaxone in Ukraine is from 6,6 UAH per bottle of 0,5 g. At the same time, there is no significant difference between prices in metropolitan pharmacies and pharmacies in other cities (Kharkov, Dnepropetrovsk, Lviv).

The price of Ceftriaxone in Russian pharmacies is from 17 rubles per bottle.

It is impossible to buy ceftriaxone tablets. The drug is intended solely for parenteral administration.

  • Online Pharmacies in Russia Russia
  • Online Pharmacies Ukraine Ukraine
  • Online pharmacies in Kazakhstan Kazakhstan


Ceftriaxone powder in / in and / m 1g No. 1 (r-l water d / in. 5 ml) Biochemist Biochemist OJSC

Ceftriaxone d / preparation. r-ra in / in and / m introduced 1 g of fl. No. 1 Biochemist OJSC

Ceftriaxone powder in / in and / m 1g No. 1 Ruzfarma Ruzfarma LLC

Ceftriaxone preparation. solution in / in and / m vv. fl. 1g№1 Biosynthesis of OJSC

Ceftriaxone d / in. fl. 1g Pharmaceutical company LEKKO CJSC

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Ceftriaxone (fl. 1 g / v / m ind. Unit.)

Ceftriaxone (fl. 1 g / m, iv)

Ceftriaxone (fl. 1 g / m, iv)

Ceftriaxone (fl. 1 g / m, iv)

Ceftriaxone (fl. 1 g / m, iv)

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Ceftriaxone powder for injection 1 g n1 fl SYNTHESIS


Ceftriaxone 1 g N10 powder PAT “Kievmedpreparat”, Ukraine

Ceftriaxone-BHFZ 500 mg No. 1 powder PAT NEC “Borshchagivsky chemical and pharmaceutical factory”, metro Kyiv, Ukraine

Ceftriaxone-Darnitsa 0.5 g N5 lyophilisate for the preparation of a solution for injection PrAT “Pharmaceutical company” Darnitsya “, Ukraine

Ceftriaxone-Darnitsa 1 g No. 5 PrAT solution “Pharmaceutical company” Darnitsya “, Ukraine

Ceftriaxone 1.0 g No. 1 powder AT “Lekhim-Kharkiv”, Ukraine

Pani Pharmacy

Ceftriaxone vial Ceftriaxone sodium salt powder for injection 1g Ukraine, Kievmedpreparat OAO

CEFTRIAXON bottle Ceftriaxone powder for injection 1g No. 5 Ukraine, Lekhim-Kharkov ZAO

Ceftriaxone vial Ceftriaxone sodium salt powder for injection 0.5g Ukraine, Kievmedpreparat OAO

Ceftriaxone bottle Ceftriaxone powder for injection 1g bottles No. 40 Ukraine, Darnitsa PrJSC

CEFTRIAXON vial Ceftriaxone powder for injection 1g Ukraine, Lekhim-Kharkov ZAO


Ceftriaxone-KMP 1 g No. 1 por.d / r-ra d / in.flak. Kievmedpreparat OJSC (Ukraine)

Ceftriaxone Sandoz® 2000 mg No. 1 por.d / r-ra d / in.flak. Sandoz GmbH (Austria)

Ceftriaxone 1 g No. 1 por.d / r-ra d / in.flak. Biosynthesis (Russia)

Before injecting ceftriaxone intramuscularly (intravenously), it is necessary to dilute the drug correctly. To do this, refer to the sheet of medical prescriptions, which details the dosage and frequency of administration of the drug. The drug is available in bottles, sealed with a rubber cap and sealed with a metal ring.

In order for the medicine to work correctly and quickly, you need to know exactly how to breed Ceftriaxone with Lidocaine. To prepare the finished solution using a 1% solution of anesthetic. In this case, the dosage established by the doctor and the drug used must be taken into account. Ceftriaxone is available in 500 and 1000 mg, so when diluting an antibiotic, you should be as focused as possible.

To prepare the necessary concentration of the active substance, you must adhere to the following schemes:

  1. To get a solution with 0,5 g of Ceftriaxone, a bottle with a dosage of 500 is diluted with 2 ml of 1% lidocaine (1 ampoule).
  2. To obtain a solution of 0,5 g of an antibiotic using a drug with a dosage of 1000 mg, 4 ml of anesthetic are diluted and 2 ml of the resulting solution is taken for infection.

There is no point in separately talking about how to dilute Ceftriaxone with water for injection – the principle is the same as with the above Lidocaine. However, in some cases, doctors have to use anesthetic and injection water at the same time. This happens if you have only 2% lidocaine solution on hand.

In such cases, proceed as follows:

  1. 2 ml of water for injection and the same amount of lidocaine are drawn into the syringe.
  2. Of the resulting solution volume, 2 ml is used for dilution of Ceftriaxone.

How to inject ceftriaxone?

To get the quick effect of taking Ceftriaxone, the injection must be carried out correctly. The place of administration of the antibiotic and the method are determined by the doctor. Doctors give preference to the intravenous method, as the fastest. As an injection site, an ulnar fold is often chosen.

With a mild infection, without complications and other concomitant pathologies, doctors can carry out outpatient treatment. In such cases, the nurse explains the patient in advance how to dilute Ceftriaxone and intramuscularly.

Regardless of how Ceftriaxone is administered, intramuscularly or intravenously, a test is performed to avoid a reaction to the use of an anesthetic (Lidocaine). Do it immediately before the injection in the treatment room.

A small amount of the drug is administered subcutaneously and observe the reaction of the body:

  1. If the injection site does not turn red, there is no burning and itching – the drug is well tolerated by the body.
  2. If the reaction appears, the drug is canceled and an alternative drug is selected.

Using ceftriaxone with lidocaine as the main treatment, the doctors determine the dosage and frequency of taking the medicine based on the collected data (severity of the disease, the presence of concomitant pathologies). In this case, the type of disease is of decisive importance.

In general, doctors adhere to the following dosages:

  • newborns (up to 2 weeks) – 20-50 mg per 1 kg of weight per day;
  • infants and children up to 12 years of age – 20–80 mg / kg per day, depending on the severity of the disease;
  • adults and children over 12 years of age – 1-2 g once a day or 0,5-1 g twice after 12 hours (daily dose – not more than 4 g).

The main question asked by patients taking Ceftriaxone is how many days antibiotic treatment lasts. Each case is individual, therefore only a doctor can correctly determine the necessary duration of therapy. Doctors recommend using the medicine for two days after the symptoms disappear and you feel better. The entire course of antibiotic treatment can last from 4 to 14 days. On average, 10 days pass from the start of treatment to recovery.

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Svetlana Borszavich

General practitioner, cardiologist, with active work in therapy, gastroenterology, cardiology, rheumatology, immunology with allergology.
Fluent in general clinical methods for the diagnosis and treatment of heart disease, as well as electrocardiography, echocardiography, monitoring of cholera on an ECG and daily monitoring of blood pressure.
The treatment complex developed by the author significantly helps with cerebrovascular injuries and metabolic disorders in the brain and vascular diseases: hypertension and complications caused by diabetes.
The author is a member of the European Society of Therapists, a regular participant in scientific conferences and congresses in the field of cardiology and general medicine. She has repeatedly participated in a research program at a private university in Japan in the field of reconstructive medicine.