Causes and diagnosis of deviations from normal basophils in the blood

Sometimes we are faced with a situation where the doctor prescribes a laboratory blood test, and within the group of leukocytes, a deviation from the norm of basophil indicators is detected. Let’s see what the fact that basophils are raised or lowered can talk about.

What are basophils

Basophils belong to the subspecies of granulocytic leukocytes. In granules of leukocytes of this type in large quantities contain histamine, heparin, serotonin, leukotriene and other mediators of inflammation and allergies.

Basophils are one of the smallest leukocyte populations. They account for no more than 1% of white blood cells. They are nucleated in the granulocyte section of the bone marrow, and these cells enter the bloodstream in a mature form.

The duration of this cell varies from 8 to 12 days.

Their main purpose is:

  1. Responding to allergic reactions related to an immediate reaction is anaphylactic shock. At those moments when the immune system is exposed to increased antigens, basophil granules eject histamine, which contributes to the production of antibodies, namely immunoglobulin. Reaching a critical level of these white blood cells entails anaphylactic shock.
  2. The heparin contained in them is necessary for the body to thin the blood and to prevent its premature coagulation, which is important for maintaining blood flow in small capillaries and blood vessels.
  3. They are responsible for combating toxins that enter the body of the victim.
  4. Fight against parasites.
  5. Maintaining the migration of the right types of white blood cells.

Considering the role of basophils, it is extremely important to understand that they do not fight against pathogens in the body, but throwing out certain substances in the affected area, only as if they call for the necessary blood cells to fight. This happens approximately as follows. These cells are the first to respond to the penetration of an aggressive agent.

They rush to the place of introduction and throw out the substances contained in the granules, which bind the allergen and slow down its spread. Basophil cells as a result of such a process in the blood become smaller, and their constituent substances in the affected tissues are greater – a focus of inflammation appears.

This becomes the attraction of other types of white blood cells.

As noted earlier, basophil cells in blood are contained in very small quantities, and as a result of this, it is rather difficult to detect their content in a smear. Such a calculation is usually performed only for the analysis of the leukocyte component with an expanded analysis.

In medical practice, these cells are usually calculated in two versions:

  • VA% – the number in relation to other types of white blood cells;
  • VA # – absolute basophil content of 0,01 – 0,065 * 109 grams / liter.

Norms for adults

The generally accepted norms of basophils in men throughout life are approximately the same, it is 0,5 – 1%. The same standards apply for women, but here it is necessary to take into account some periods of life in which a number of deviations are permissible:

  • the period of menstruation and ovulation is characterized by an increase in estrogen, which means a slight increase in this type of white blood cells;
  • pregnancy during the first trimester is characterized by a decrease relative to accepted standards.

Norms for children

Scout cell counts usually stabilize at only twelve years old. During the first years of life, changes will occur in parallel with the process of growing up:

  • newborn baby – 0,75%;
  • 1 month – 0,5%;
  • 2 months – 1 year – 0,4 – 0,9%;
  • up to 12 years old – 0,7%;
  • from 12 to 21 years old – 0,6 – 1%.

The newborn baby will have the highest rate as a result of the fact that his immune system only goes through the formation process. After the end of this process, basophil indicators gradually return to normal.

Deviations from the norm

Sometimes with a detailed analysis of blood for basophils in the leukocyte component, a deviation from the accepted norms is noted. Two options can be noted here:

  • basophilia – increased content of these white cells;
  • basopenia – reduced content.

Elevated level

Faced with this result, do not immediately panic. It is advisable to wait a few days and go through this study one more time.

In the event of a repetition of the situation, you must seek the help of a doctor as soon as possible. This is especially true of increasing or decreasing white blood cells of this type in a child.

The indicator, when basophils are above normal, usually indicates the development of pathological processes in the body, and this may be:

  • hepatitis;
  • infection;
  • disorders in the thyroid gland;
  • allergic reaction;
  • a tumor of a benign or malignant nature;
  • blood diseases;
  • endocrine system pathologies;
  • gastrointestinal diseases;
  • various intoxications.

When conducting an analysis, it is imperative to consider which medicines the patient has taken previously. In a child, an increase in the blood of this type of white blood cells can develop as a result of a prolonged or chronic allergy.

If a blood test shows a decrease in basophils, then it is worth considering the following nuances:

  • stressful situation;
  • hyperthyroidism;
  • increased thyroid function;
  • pneumonia;
  • Cushing’s disease;
  • violation of the adrenal glands.

Blood sampling is carried out in specialized laboratories. Blood is most often taken from the finger – everyone is probably familiar with this procedure, but to get the correct results, it’s best to prepare a little for the tests:

  • the analysis is given on an empty stomach – the last meal should not be earlier than 8 hours;
  • increased physical activity should be postponed for about a day;
  • do not drink alcohol for at least 24 hours;
  • before the surrender you need to try not to be nervous;
  • the doctor must be warned in advance about taking any medications, and he will advise – which medications should be temporarily interrupted.

In the event that changes in the composition of the blood are the result of any disease, then, naturally, to bring the indicators back to normal, it will be necessary to cure this disease. At the end of treatment, the patient is usually prescribed a second blood test and a comparative analysis of the situation is performed.

If the change in indicators is not associated with diseases, then a person needs to pay attention to the diet. One of the vitamins needed to produce these white cells is B12.

Thus, it is important to include in sufficient quantities meat, eggs, milk, liver, etc. It is also important to eat fish and other seafood.

You can activate the absorption of iron by adding dry white wine or orange juice to the diet.

Despite the small number of basophils, in comparison with other blood cells, it is impossible to say that they are less important for the body. Like all white blood cells, basophils perform a protective function, being the first to respond to an allergen or infection. Their reaction leads to the mobilization of the remaining cells of this species – granulocytes to the lesion.

Like other blood cells, basophils can change their concentration, which is often a sign of a disease, sometimes quite serious. Therefore, if upon passing the analysis it turned out that the basophils in the blood are lowered or increased, then you should go to a specialist for a consultation and a comprehensive examination as soon as possible.

Basophils are a subspecies of granulocytes, along with blood cells such as neutrophils and eosinophils, and belong to the type of leukocytes, which also includes lymphocytes and monocytes. Basophilic granulocytes have an S-shaped nucleus, which is quite difficult to discern even on powerful microscopes due to granules of histamine and other allergy mediators that overlap the cytoplasm.

These cells are the largest of all granulocytes. They contain a large number of mediators of allergic and inflammatory processes: histamine, prostaglandins, serotonin, leukotrienes, etc. Basophils serve as mediators in the formation of allergic reactions of the immediate type (anaphylactic shock).

Thanks to these blood cells, poisons are blocked, which prevents their spread throughout the body. In addition, basophils are responsible for the regulation of coagulation by heparin. On their surface, they carry immunoglobulin E, and are capable of cell lysis (dissolution) or degranulation (recoil of granules) upon contact with an allergen.

The main task of these cells is rapid degranulation, causing an increase in blood supply, vascular permeability, as well as the influx of fluid and other granulocytes. That is, the primary goal of basophils is to attract other cells of this species to the source of inflammation.

Reference! With a prolonged inflammatory reaction (over 3 days) in the bone marrow, the production of new blood cells of this subspecies increases, leading to basophilocytosis or basophilia (increased basophils).

Brief information on the functions of basophilic granulocytes

Since basophilic granulocytes belong to the type of leukocytes, their number is determined as a percentage of the total number of these blood cells. In some cases, absolute values ​​are indicated in the analysis forms. The norm of basophils in the blood of adults, that is, the specific gravity, is 0–1 percent and the absolute value is 0–0,065 * 109 g / l.

Normal indicators of basophilic granulocytes in children almost do not differ from the parameters of an adult and are equal to 0,4-0,9%. In the forms of medical tests, information about these cells is as follows: VA% (basophils) is a relative indicator and VA (basophils abs.) Is the absolute content of basophils. More information about basophils in the blood of a child can be found in this article.

The level of basophils in the blood is a kind of indicator of the presence of allergic or inflammatory processes in the human body.

This indicator is not decisive in the diagnosis, but in most situations the doctor needs to understand the full picture that determines the functional activity of white blood cells.

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The main conditions in which basophils can be elevated

If basophils are elevated in an adult, then there may be several reasons:

  1. Various allergic reactions (dermatitis, urticaria, insect bite, exacerbation of bronchial asthma, etc.). The more acute the allergy, the sharper the basophils increase
  2. Chronic autoimmune diseases – type 1 diabetes mellitus, hypothyroidism, ulcerative colitis, hepatitis, nephrosis.
  3. Chronic myeloid leukemia.
  4. Lymphogranulomatosis.
  5. Infestation by parasites.
  6. Condition after removal of the spleen.
  7. Estrogen treatment.
  8. In women, the content of basophils may increase during menstruation.

The main function is to prevent the penetration of infections and harmful bacteria into the human body. These cells help to heal cuts, wounds, forming a protective crust through lymphocytes. In the healing process, white bodies are destroyed, irritation, itching, tissue near the wound can swell. But that is not all. In addition to the main function, basophils have additional ones:

  1. They contain heparin – a substance that dilutes the blood and prevents its coagulation.
  2. Remove poisons and toxins.
  3. Prevent the occurrence of anaphylactic shock and allergic reactions. If the immune system is subject to excessive exposure to antigens, histamine is released by white cells. They also contribute to the production of special antibodies (agents), which are called immunoglobulin. Thanks to this, itchy skin is mitigated.
  4. Kill parasites, for example, ticks.

As you can see, the functions of basophils are unique.

The main task of these cells is rapid degranulation, causing an increase in blood supply, vascular permeability, as well as the influx of fluid and other granulocytes. That is, the primary goal of basophils is to attract other cells of this species to the source of inflammation.

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Basophil norm

It is believed that the norm of basophil content in a child is slightly lower than in adults (no more than 0,5%), but it is clear that this difference is very arbitrary. In any case, if the laboratory assistant sees one basophil per 100 cells, the analysis will have the figure of 1%, and this will not be a pathology.

Elevated basophils in a child most often indicate allergies or helminthic infestations. Much less often, the reason will be different. If a blood test is taken after vaccination, basophilia can also be observed.

A decrease or absence of basophils in the blood has no diagnostic value.

The level of basophils in the blood is a kind of indicator of the presence of allergic or inflammatory processes in the human body. This indicator is not decisive in the diagnosis, but in most situations the doctor needs to understand the full picture that determines the functional activity of white blood cells. With its help, it is possible to track the reaction of white blood cells in response to the action of various pathogens.

  • diseases of the blood-forming organs (hemolytic anemia);
  • diabetes mellitus, intoxication of various etiologies, chickenpox;
  • myxedema – pancreatic insufficiency;
  • acute and chronic diseases of the digestive system (gastritis, ulcerative colitis, stomach ulcer and 12 duodenal ulcer);
  • allergic reactions: damage to the respiratory organs, itching, urticaria, dermatitis, eczema and others;
  • neoplasms in the lungs and bronchi in the initial stages.

Also, the cause of elevated basophils may be taking corticosteroid drugs, estrogens, or hormones prescribed for thyroid dysfunction. Allergic reactions and blood pathologies are the groups of the most common conditions when an excess of the norm of these cells is noted in the analysis of the blood of adults. In a child, such manifestations are caused by similar causes, but poisoning with toxic substances and helminthic infestations are still worth adding to them.

The blood pathologies leading to basophilocytosis include a list of diseases such as acute and chronic leukemia (malignant pathology of the hematopoietic system), Hodgkin’s disease or lymphogranulomatosis (pathology of the lymphatic system that is malignant), true polycythemia (damage to the hematopoietic system of a benign nature). Each of these pathologies can cause an increase in the number of any leukocyte groups, not excluding basophilic granulocytes.

Important! Slightly elevated basophils may be evidence of the development of an acute or chronic inflammatory process in both adults and children.

The processes that perform the protective function of the body from adverse effects can occur in the respiratory, urinary, and also digestive systems. The negative influence of factors gives a signal for triggering an immune response, as a result of which hormones and enzymes that are found in granules of basophils become necessary.

The process of releasing granules of basophil cells in tissue

The breakdown of basophilic granulocytes leads to the release of prostaglandin, histamine and other elements, which is the impetus for triggering a protective reaction of tissues to the antigen that has entered the body. In addition, there are several more non-pathological situations in which basophils can also be elevated.

It is also worth mentioning that iron deficiency in the body often leads to an increase in the number of basophils. From the foregoing, it follows that if a general blood test indicated an increase in the content of these cells, then what this increase means is accessible only to a specialist. Self-diagnosis in such situations will not bring the desired result, and delaying a visit to the doctor will only aggravate the development of the disease.

In most cases, when choosing the right treatment strategy to rid the patient of the underlying disease, and its timely appointment, the number of basophils comes back to normal. If the cause of basophilocytosis lies in the prolonged use of hormonal drugs, then medications cancel or select analogues that do not cause similar side effects.

To normalize the blood formula after treatment of infectious and inflammatory diseases, patients are prescribed an additional course of vitamins, as well as a diet with the inclusion of foods that contain a lot of B12. This approach has a beneficial effect on hematopoietic function, which affects the general condition of a person.

A change in the blood formula in which basophilic granulocyte counts are lowered is called basophilopenia. It speaks of the depletion of reserves of white blood cells (white blood cells) in the blood. In some cases, when conducting a blood test, it is found that basophils are simply absent. The reasons for the decrease in the number of these granulocytes in adults have a fairly wide range.

Of them stand out:

  • acute infectious diseases;
  • increased physical activity, including sports;
  • prolonged starvation, strict diets, leading to exhaustion of the body;
  • hyperthyro >

Normal indicators for the components of the leukocyte formula

Often, a decrease in the number of VA is observed in pregnant women in the first trimester. But such values ​​are considered false, since the level of these cells, like the rest, decreases due to an increase in the total volume of blood through an increase in its liquid part. As a result, it turns out that the number of basophils remains unchanged, but the concentration per unit volume decreases. At the same time, it will be useful to note that not all conditions leading to basophilopenia require medical attention.

Often these blood elements come to normal levels on their own. Lowering the level of basophils in adults is not explicitly important for diagnosis, so often there is no need to pay attention to its slight fluctuations. But with a marked decrease or increase in the values ​​of these blood cells, the doctor will most likely prescribe a set of additional diagnostic measures to find the cause of these deviations.

In percentage terms, the number of basophilic granulocytes is minimal compared to neutrophils, lymphocytes, monocytes and eosinophils. The number of cells does not depend on the time of day, however, in order to obtain the most accurate results, it is recommended to take an analysis in the morning up to 10 hours.

Normal valuesPercentage of total leukocyte countAbsolute values
Age and gender do not matter0 – 1%0 – 0,09 * 10 9 / l

It should be noted that absolute values ​​reflect a more accurate picture of health than a percentage. If a person has elevated basophils in a clinical blood test, then a second study with a leukocyte formula is prescribed. If necessary, the number of cells is counted manually under a microscope.

The reasons for the increase in basophils in a child are not always pathological. A short-term increase in their concentration is observed in children with:

  • the need for medication. Especially if they contain components that cause an allergic reaction;
  • the introduction of foreign proteins;
  • a latent inflammatory process that does not manifest itself in the form of clinical symptoms. In this case, it is recommended to undergo a comprehensive examination and exclude sluggish inflammation;
  • a recent vaccination or insect bite, which can provoke an allergic response.

Therefore, in the case of obtaining results that deviate from the norm, do not worry. Repeated analysis of the child is recommended 5-7 days after the exclusion of external factors.

When re-identifying overestimated indicators, a large-scale diagnostic examination of a small patient is carried out in order to establish a diagnosis. The reasons for the increase in the concentration of basophilic granulocytes are similar to adult patients.

Note: The norm of lymphocytes in the blood of a child by age in the table

In the analysis form, you can see the following basophil indicators:

  • VA% (relative amount as a percentage of other leukocytes)
  • VA # (absolute amount)

Important! It should be noted that in each laboratory the standards will be slightly different – this is due to the specifics of the equipment used in each particular laboratory.

So, in the Invitro laboratory, the values ​​are normal:

  • 0-1,0% 2 in the framework of the leukocyte formula

Helix Lab defines the following ranges3:

  • absolute values ​​- 0-0,08 * 10 9 / l
  • relative – 0-1,2%

Leukocytogram reference indicators

  • adults – 0-1%
  • newborns – 0,75%
  • 1 day of life – 0,25%
  • 2 weeks – 0,5%
Reference values ​​of the absolute and relative content of basophils in the blood
AgeAbsolute amount
10 9 / l
Relative
quantity,%
12 months.0 – 0,20,4
4-6 years0 – 0,20,6
10 years0 – 0,20,6
21 year0 – 0,20,5
Adults0 – 0,20,5

Important! Interpretation of results is always carried out comprehensively. It is not possible to make an accurate diagnosis based on just one analysis.

The basophil level is determined by a clinical blood test. The concentration of such bodies is set as a percentage of the total number of lymphocytes in the form of absolute and relative values. The absolute amount, regardless of age, is from 0,01 to 0,065 * 109 g / l, the relative amount directly depends on the person’s age and has the following indicators: 0,75% – newborns; 0,5% – baby from one month; 0,6% are one-year-old children; 0,7% – two-year; 0,5-1% – adult category.

What are basophils

Eosinophils, neutrophils, lymphocytes and monocytes

The content of basophils from all leukocytes is only 0,5%. In addition to this type of body, the following types can be found in the blood:

  1. Neutrophils. The largest group of white blood cells that fight severe infectious conditions.
  2. Lymphocytes They are part of the immune system, preventing the invasion of viruses and bacteria (pathogens).
  3. Eosinophils. They help fight parasitic infections. The functions of basophils and eosinophils play an important role in the body.
  4. Monocytes fight infections in the bloodstream, antigens, help restore damaged tissues, and also destroy cancer cells.

Let us consider in more detail the functions of basophils in immunology.

What are the deviations from the norm?

The content of basophils in the blood formula is not more than 1%. They may not be in the smear at all, this is not considered a pathology.

An increase in basophils in the blood (basophilia) is quite rare.

What are elevated basophils talking about? As already mentioned, basophilic leukocytes are active participants in allergic reactions of both immediate and delayed types. Therefore, the main reason is allergy.

When an allergen enters the body, mast cells, that is, tissue basophils, are the first to react to it. A focus of allergic inflammation is formed. Basophils from the blood rush into this focus. During this period, their increase is noted.

The second reason for basophilia is their increased formation in the bone marrow. This condition can be with myeloid leukemia, erythremia and some other diseases of the hematopoietic system.

If basophils are elevated in an adult, then the doctor initially suggests the development of an allergic response. Allergens may include foods, plant pollen, dandruff and epithelium of domestic animals, ticks, plant pollen, and medications. Their number reaches tens of thousands, so the determination of a specific allergen is difficult in practice (for this a set of special tests with allergens is performed).

The doctor collects the patient’s history, including a hereditary predisposition to individual intolerance to various substances. Diagnosis is facilitated by information about the specific reaction of the human body to contact with certain allergens. If it is impossible to determine the irritant by an allergic history, a skin test or measurement of specific class E immunoglobulins in the blood is performed.

Currently, complex allergy chips have been developed. Thanks to which it is possible to simultaneously establish the patient’s sensitivity to 110 allergens from 50 sources. The disadvantage of the technique is its high cost.

One of the reasons for this condition is ulcerative colitis, when inflammation of the mucous membrane of the colon of a person occurs. Possible causes: hereditary predisposition, infection by pathogens, complication after taking oral contraceptives or smoking.

Basophils above normal are determined in the results of tests for chronic hemolytic anemia. The incidence of the disease is extremely rare. It manifests itself in the form of uncontrolled destruction of red blood cells. As a result, the synthesis of red blood cells is activated in the human body and the concentration of their decay products is significantly increased.

The prognosis of the outcome is typically favorable. In the case of the development of the disease against external factors, as a rule, their cancellation leads to recovery. An exception is the congenital form of pathology, but even in this case, the methods of modern medicine provide a person with a long-term remission.

The patient should also be checked for cancer of various localization. First of all, it is necessary to exclude a malignant lesion of the circulatory system (leukemia). As a rule, these pathologies are accompanied by deviations from the norm of all parameters of the clinical blood test.

Despite the fact that phagocytosis is not the main function of basophilic granulocytes, their increase can be observed with infectious infections. For example, tuberculosis, chickenpox, or viral flu. Activation of human immunity and increased production of all protective blood cells occurs.

Also, the level of basophils can increase in chronic myelogenous leukemia (eosinophilic-basophilic associations), myxedema (a decrease in the synthesis of thyroid hormones), nephrosis, Hodgkin’s disease, after splenectomy, as well as during therapy with estrogen and antithyroid drugs.

A moderate decrease in the rate during therapy with a high content of basophilic granulocytes is a sign of correctly selected treatment methods.

In most cases, a decrease in basophil levels in the blood does not have a diagnostic value. The exception is cases where there is a complete absence of basophils and a decrease in all leukocyte cells.

Possible causes of such changes in the blood:

  • exhaustion of the body against a background of chronic pathologies;
  • inhibition of the immune system;
  • pronounced physical or emotional stress;
  • malfunctions of the endocrine system and a violation of the normal hormonal background. For example, an excess of thyro >

If the results of the analysis in an adult or child in the column “basophils” indicates 0 (zero), then this may be a variant of the physiological norm. In the absence of symptoms of pathologies, the condition does not require medical attention. The required amount of basophilic granulocytes is produced by the bone marrow as needed.

Fabric basophils

Tissue basophils (mast cells, mast cells, mast cells) are found in subcutaneous fat and in all layers of the dermis. There is an opinion that young tissue basophils are formed in the papillary layer (their precursors are evicted here from the microscopic part of the vascular bed), and then, as they mature, they move into the subcutaneous tissue and the layers of the dermis, which are lower, while increasing in size.

For tissue basophils, the source of development is a blood stem cell, a later descendant of which is the same for them and for basophilic leukocytes in the blood. The concentration of mast cells in the skin in various mammalian species differs and is inversely proportional to the number of basophilic granulocytes in the blood.

Their large-scale penetration into the epidermis is observed with skin mastocytomas. Mast cells have a clear polymorphism, which is manifested by the degree of filling with granules of the cytoplasm, various shapes of cells (from round to angular and elongated), their size. Cells have a small oval or rounded in some cases hyperchromic nucleus.

The cytoplasm of tissue basophils includes organelles: two types of endoplasmic reticulum, mitochondria, Golgi complex, microfilaments, ribosomes, and in some cases centrioles. They are located near the nucleus, the degree of their development is determined by cell maturity. In young cells they are maximally developed, in mature cells they are almost invisible due to the concentration of a large number of granules. What are the main functions of tissue basophils?

What kind of basophil cells

The functional role of mast cells by biologically active substances that are contained in granules is determined. They regulate microvascular tone and permeability, the amount of water in the skin, support the colloidal state of the main component of connective tissue. Mast cells play a significant role in maintaining a normal metabolic level in the skin.

Due to biologically active substances, tissue basophils are often involved in skin pathological processes. In this case, tissue edema and massive degranulation are noted in them, that is, the exit of granules, whose contents can cause the expansion of microvessels, and the exit of blood cells from them, primarily non-granular and granular leukocytes.

The functions of basophils in the blood are now known. What are the norms?

Basophils in the total number of leukocytes occupy the smallest position. Normally, their number does not exceed 1% of all white blood cells. They relate to granulocytes, that is, cells having granules with various biologically active substances in the cytoplasm.

Granules of basophils are intensively stained with the main aniline dye, hence the name of these cells. Under a microscope, they look like cells with a large, weakly segmented dark blue or violet nucleus (often S-shaped), their cytoplasm is filled with large granules colored in various shades of purple, the nucleus behind these granules is poorly visible.

Basophilic white blood cells form in the bone marrow, then they enter the bloodstream, where they circulate for only a few hours. Then they enter the tissue, where they perform their main function.

How to lower basophils?

All treatment should be prescribed exclusively by a specialist. The complex of therapy is caused by the main disease that caused a decrease or increase in the level of basophilic cells.

If the deviation from the norm is insignificant, then the patient is prescribed a complex of vitamins. For example, B vitamins have a positive effect on the hematopoiesis process and regulate the number of cells in white blood cell subpopulations.

You can also get vitamins from food, for example:

  • beef meat and beef offal (liver, kidney, tongue);
  • pork liver;
  • rabbit;
  • egg yolks;
  • seafood (shellfish, oysters, crabs);
  • fish (herring, mackerel, chum)
  • dairy products (kefir, yogurt, cottage cheese);
  • lettuce leaves;
  • spinach;
  • green onions.

Regular use of these products will prevent the development of anemia.

If the patient was taking medications, then they should be canceled and the analysis repeated. It is possible that it is the drugs that are the reason for the increase in the concentration of basophilic granulocytes.

In infectious infections, it is necessary to initially conduct a course of antiviral therapy. The etiological affiliation of the infectious agent is determined: virus, bacteria or microscopic fungi.

If a bacterial infection is detected, an additional test is performed – an antibioticogram, which allows you to choose the most effective drug. Therapy of viral infection consists of the appointment of antiviral and immunostimulating drugs. Mixed infection involves the selection of various groups of drugs. Fungal diseases are treated similarly to bacterial infections, only with the use of antimycotics.

The norm of basophils in the blood, causes and diagnosis of deviations

The condition develops with an increase in the number of basophils more than 0,2 * 109 / L.

Important! Hormonal drugs (estrogens), antithyroid drugs can cause basophilia. The number of basophils also increases in women in the early days of the cycle.

In clinical practice, an increase in basophils is rare and occurs with:

  • diseases of the digestive tract (chronic form):
  • acute inflammatory process of the liver;
  • pathologies of the circulatory system:
  • individual reaction to an irritant (allergy);
  • stages of early remission of infectious diseases;
  • hypothyroidism (thyroid insufficiency, expressed in a decrease in its secretory function);
  • diabetes mellitus;
  • Hodgkin’s disease (malignant pathology affecting the lymphatic system);
  • oncology (blood, lung cancer);
  • with prolonged exposure to small doses of ionizing radiation.

An increase in the number of basophils indicates a violation of the immune system and an active invasion of a foreign agent. Also, chronic basophilia is noted in patients who have removed the spleen.

What are basophils

With the continuation of the inflammatory reaction for more than three days, increased production of new basophils above normal occurs in the bone marrow. An increase in the number of these cells in the blood (over 0,2 * 109 / l) is called basophilocytosis, or basophilia. The cause of this process may be the final stage of acute inflammation or the presence of various pathologies.

The diseases and conditions in which basophils can increase are as follows:

  • allergic reactions to drugs, products and other substances;
  • blood pathology (acute leukemia, myelogenous leukemia, granulomatosis, etc.);
  • chronic diseases of the stomach and intestines;
  • pathologies of the thyroid gland;
  • chronic sinusitis;
  • viral infections;
  • diabetes;
  • hemolytic anemia;
  • Hodgkin’s disease;
  • the use of antithyroid drugs and estrogens;
  • before menstruation and ovulation period.

The cause of basophilia is often the lack of iron in the human body. Basophils can also be elevated in people who have undergone spleen removal surgery. Basophilocytosis in any case shows the ongoing changes in the body, leading to serious consequences or insignificant. That is why, when basophilia is detected, it is necessary to undergo a comprehensive examination so as not to miss the alarm signal and start treatment in time if any disease is detected.

To reduce the number of basophils, the reason for their increase should be eliminated. The specialist examines the patient and, based on the results of the analyzes, determines the therapy. But basophils can increase in healthy people. This is most often due to a lack of iron. To replenish its reserves in the body, you should eat red meat, seafood, liver, vegetables, oily fish and fruits.

For better absorption of iron by the body, it is advisable to drink orange juice during meals. In some cases, specialists prescribe iron supplements. Sometimes, to reduce basophils, it is enough to cancel taking antithyroid drugs and estrogens. Vitamin B12 (most often in the form of injections) will help normalize their content. Its natural sources are yeast, eggs, milk, meat, etc.

If basophils are reduced, this is called basopenia. This condition is difficult to assess due to their low content. Basopenia may be in pregnant women, and this is most often the norm. A reduced concentration is sometimes observed in acute infections and hyperthyroidism, as well as as a result of the use of corticosteroids.

Basophils are invisible and at the same time important participants in the hematopoietic process. They are the first to signal allergies, directing the actions of other blood cells. If a person knows his basophil level, you can draw conclusions about the state of his immune system. The article examined the basic functions of basophils.

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Svetlana Borszavich

General practitioner, cardiologist, with active work in therapy, gastroenterology, cardiology, rheumatology, immunology with allergology.
Fluent in general clinical methods for the diagnosis and treatment of heart disease, as well as electrocardiography, echocardiography, monitoring of cholera on an ECG and daily monitoring of blood pressure.
The treatment complex developed by the author significantly helps with cerebrovascular injuries and metabolic disorders in the brain and vascular diseases: hypertension and complications caused by diabetes.
The author is a member of the European Society of Therapists, a regular participant in scientific conferences and congresses in the field of cardiology and general medicine. She has repeatedly participated in a research program at a private university in Japan in the field of reconstructive medicine.

Detonic