Analogs of Xarelto 20 mg and 15 mg, which is better – Xarelto or Pradaxa, Xarelto or Elikvis tablets

Diet when taking “Warfarin”

The effectiveness of this product depends on the content of vitamin K. It enters the body with certain products, especially with leafy greens. But you do not need to drastically increase or decrease the proportion of these vegetables in the diet. Starting taking the medicine, you should not make changes to the usual menu or take vitamins or dietary supplements without coordinating this with your doctor.

When the dose of the drug is selected and already established, a sharp increase in the consumption of foods rich in vitamin K content can reduce its effectiveness and lead to increased thrombosis. The greatest amount of this vitamin is found in green tea, spinach, parsley, cabbage of different varieties, salad. A sharp introduction to the diet of these products can lead to a weakening effect of the drug, and regular consumption of berries or cranberry juice, on the contrary, can lead to an increase in its effectiveness. Drinking alcohol is absolutely unacceptable. That is, a diet when taking “Warfarin” is a prerequisite for a successful and safe treatment.

Drug “Warfarin”

This substance is the oldest of the above anticoagulants. Its use requires careful observance of the dosage and monitoring of the blood condition, since excess doses are very dangerous – the drug “Warfarin” in this case becomes a poison. Use it for the treatment and prevention of thrombosis and embolism of blood vessels.

In particular, it is prescribed for acute and recurrent venous thrombosis, pulmonary artery embolism, transient ischemic attacks and strokes, as well as for the secondary prevention of myocardial infarction and its associated thromboembolic complications. The medicine is also used to prevent thromboembolic complications in patients with atrial fibrillation, damage to the heart valves or with prosthetic heart valves, as well as in the postoperative period after orthopedic interventions to reduce the risk of blood clots.

“Warfarin” tablets are not used for hypersensitivity to the components of the drug, for acute bleeding, pregnancy (especially during the first trimester and in the last 4 weeks), since it has teratogenic effects for the fetus, severe kidney and liver diseases, acute DIC syndrome, deficiency of C and S proteins, thrombocytopenia.

Also, it is not prescribed for patients who are suspected of developing bleeding (including hemorrhagic disorders), suffering from varicose veins of the esophagus, aneurysm of the arteries, peptic ulcer of the stomach or duodenum, bacterial endocarditis, and malignant hypertension.

Anticoagulants, preventing excessive clotting, can sometimes have a negative effect on the body, causing increased bleeding. This effect has the drug “Warfarin”. Side effects are reduced mainly to bleeding of different localization. In addition, there may be violations of the digestive system.

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Indications for use

This pharmacological group of drugs that affects the body in the most serious way requires very careful handling and strict adherence to dosage. Only a doctor can prescribe such a remedy. This anticoagulant is used to prevent the occurrence of venous thromboembolism in patients with a history of any orthopedic surgery, as well as to prevent the development of stroke, systemic thromboembolism and to reduce cardiovascular mortality in people suffering from atrial fibrillation.

As already mentioned, the drugs from this group have a serious effect on the body, so they are prescribed only for very strict indications.

– hypersensitivity to substances such as dabigatran “, abigatran etexilate or to auxiliary components included in the composition;

– severe renal failure (CC less than 30 ml / min);

– intense clinically significant bleeding, hemorrhagic diathesis, spontaneous or pharmacologically induced hemostasis;

– organ damage as a result of significant bleeding, including hemorrhagic stroke, within 6 months before treatment;

– the simultaneous appointment of “Ketoconazole” for systemic use;

– impaired function or liver disease affecting survival;

– the patient’s age is up to 18 years (since there are no data from clinical studies).

Despite the significant list of contraindications for the drug “Pradaksa”, reviews of doctors still characterize it as safer compared with some of its analogues.

This medicine, manufactured by the Beringer Ingelheim company in Austria and Germany, is available in the form of capsules containing the active substance 75 mg, 110 mg and 150 mg. Capsules are taken orally without opening, regardless of food intake. Multiplicity of admission – up to 2 times a day.

For the prevention of venous thromboembolism in patients undergoing orthopedic surgery, the drug “Pradaksa” 110 mg is administered once in two capsules. Patients after knee arthroplasty are advised to start taking the medication no later than 4 hours after the end of the operation. The course of treatment is 10 days. For hip arthroplasty, the drug should be continued until 28-35 days.

For the prevention of ischemic stroke in patients with non-valvular atrial fibrillation, a dosage of 150 mg 2 once a day of the drug “Pradax” is prescribed, reviews of which show a good percentage of prevented pathological conditions.

Anticoagulants, preventing the formation of blood clots, cause a decrease in blood coagulability, which determine the general manifestation of undesirable effects. From the lymphatic and circulatory systems, thrombocytopenia and anemia can occur. Disorders in the immune system can manifest as a hypersensitivity reaction (urticaria, itching, rash, bronchospasm).

Increased vascular permeability can cause hematomas, bleeding of various localization, including intracranial, nasal, gastrointestinal and others. From the digestive organs, pain, dyspepsia, vomiting, dysphagia, gastroesophagitis, liver dysfunction and other abnormalities of the gastrointestinal tract may occur.

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Elikvis is an anticoagulant with direct exposure. The medicine is prescribed for therapeutic and prophylactic purposes to people with problems of the vascular system. The drug has some contraindications for use, it can cause the development of adverse reactions, so taking this medication without consulting a doctor is not recommended.

It is produced in the form of round or oval biconvex tablets, which are covered by a film membrane. The active component of the drug is apixaban. In tablets, this substance is contained in a dosage of 2,5 or 5 mg.

As additional components in the manufacture of the drug used:

  • croscarmellose sodium;
  • sodium lauryl sulfate;
  • magnesium stearate;
  • microcrystalline cellulose;
  • lactose free.

– hypersensitivity to substances such as dabigatran “, abigatran etexilate or to auxiliary components included in the composition;

– severe renal failure (CC less than 30 ml / min);

– intense clinically significant bleeding, hemorrhagic diathesis, spontaneous or pharmacologically induced hemostasis;

– organ damage as a result of significant bleeding, including hemorrhagic stroke, within 6 months before treatment;

– the simultaneous appointment of “Ketoconazole” for systemic use;

– impaired function or liver disease affecting survival;

– the patient’s age is up to 18 years (since there are no data from clinical studies).

This medicine, manufactured by the Beringer Ingelheim company in Austria and Germany, is available in the form of capsules containing the active substance 75 mg, 110 mg and 150 mg. Capsules are taken orally without opening, regardless of food intake. Multiplicity of admission – up to 2 times a day.

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Svetlana Borszavich

General practitioner, cardiologist, with active work in therapy, gastroenterology, cardiology, rheumatology, immunology with allergology.
Fluent in general clinical methods for the diagnosis and treatment of heart disease, as well as electrocardiography, echocardiography, monitoring of cholera on an ECG and daily monitoring of blood pressure.
The treatment complex developed by the author significantly helps with cerebrovascular injuries and metabolic disorders in the brain and vascular diseases: hypertension and complications caused by diabetes.
The author is a member of the European Society of Therapists, a regular participant in scientific conferences and congresses in the field of cardiology and general medicine. She has repeatedly participated in a research program at a private university in Japan in the field of reconstructive medicine.

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